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Trilafon, |perphenazine

perphenazine

Generic Name: perphenazine (per FEN a zeen)
Brand Names: Trilafon

What is perphenazine?

Perphenazine is in a class of drugs called phenothiazines. It works by changing the actions of chemicals in your brain.

Perphenazine is used to treat psychotic disorders, nausea, and vomiting.

Perphenazine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about perphenazine?

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Who should not take perphenazine?

Before taking this medication, tell your doctor if you have

• a bone marrow disease,

• glaucoma,

• seizures,

• Parkinson"s disease,

• an enlarged prostate or difficulty urinating,

• liver disease, or
• kidney disease.

You may not be able to take perphenazine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

How should I take perphenazine?

Take perphenazine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Perphenazine can be taken with or without food.

Mix the concentrate with 4 ounces of water, juice, ginger ale, or a semisolid food such as applesauce or pudding.

Throw away any discolored liquid.

What happens if I miss a dose?

If you take one dose of perphenazine a day, take the missed dose as soon as you remember, then go back to your regular schedule the next day. If you do not remember until the next day, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

If you are taking perphenazine on a regular schedule several times a day, take the missed dose within 1 hour of its regular time. If more than 1 hour has passed, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

If you are taking perphenazine as needed for nausea and vomiting, take the missed dose as soon as possible, then wait at least 4 hours before taking another dose.

What happens if I overdose?

Symptoms of a perphenazine overdose include uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature.

What should I avoid while taking perphenazine?

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Perphenazine side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• uncontrollable movements of the tongue, face, lips, arms, or legs;

• muscle spasms of the face or neck;

• severe restlessness or tremor;

• severe drowsiness or fainting; or

• a rash.

Other, less serious side effects may be more likely to occur. Continue to take perphenazine and talk to your doctor if you experience:

• decreased sweating;

• dry mouth, stuffy nose;

• constipation;

• blurred vision;

• mild restlessness, drowsiness, or tremor;

• difficult urination or dark urine;

• decreased sex drive;

• dizziness;

• increased appetite; or

• menstrual irregularities or swollen breasts.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect perphenazine?

Before taking this medication, tell your doctor if you are taking any of the following drugs:

• antacids. Take antacids at least 2 hours before or 2 hours after taking a dose of perphenazine. They will decrease the effectiveness of perphenazine.

• alcohol; over-the-counter cough, cold, or allergy medications; sleep aids; antidepressants; muscle relaxants; barbiturates; and seizure medications. All of these medications will increase the side of effects of perphenazine--especially drowsiness and dizziness.

• blood pressure medications such as propranolol (Inderal), methyldopa (Aldomet), and clonidine (Catapres). These drugs may cause dizziness and fainting if used with perphenazine.

• anticoagulants such as warfarin (Coumadin). Perphenazine may decrease the effectiveness of these medications, and blood clotting could result.

• phenytoin (Dilantin). Perphenazine may increase the effectiveness of phenytoin and cause side effects. You may need smaller doses of phenytoin.

Drugs other than those listed here may also interact with perphenazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about perphenazine written for health professionals that you may read.

What does my medicine look like?

Perphenazine is available with a prescription under the brand name Trilafon in tablet and concentrate (liquid) formulations. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Trilafon 2 mg--round, gray, sugar-coated tablets

• Trilafon 4 mg--round, gray, sugar-coated tablets

• Trilafon 8 mg--round, gray, sugar-coated tablets

• Trilafon 16 mg--round, gray, sugar-coated tablets

• Trilafon Concentrate--16 mg/teaspoon (5 mL) in a dropper bottle

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.