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|Perphenazine

Perphenazine

Perphenazine is used for:

Treating schizophrenia. It may also be used to treat severe nausea and vomiting. It may also be used for other conditions as determined by your doctor.

Perphenazine is an antipsychotic. It works by blocking dopamine receptors in the brain.

Do NOT use Perphenazine if:

• you are allergic to any ingredient in Perphenazine
• you have certain types of brain damage
• you have blood disorders, liver damage, or decreased bone marrow function
• you are taking astemizole, cisapride, dofetilide, terfenadine, or tramadol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Perphenazine :

Some medical conditions may interact with Perphenazine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of seizures, breast cancer, asthma, trouble urinating, lung problems (eg, emphysema), alcohol abuse, or depression
• if you have a lung infection, heart or blood disease, Reye syndrome, Parkinson disease, glaucoma, high or low blood pressure, or prostate problems

Some MEDICINES MAY INTERACT with Perphenazine . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, benztropine), antihistamines (eg, diphenhydramine), barbiturates (eg, phenobarbital), opiates (eg, codeine), or tricyclic antidepressants (eg, amitriptyline) because the side effects of Perphenazine may be increased
• Astemizole, cisapride, dofetilide, haloperidol, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, erythromycin), pimozide, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), terfenadine, or tramadol because the risk of severe heart, nervous system, or muscle problems or seizures may be increased
• Guanethidine, levodopa, or pergolide because effectiveness may be decreased by Perphenazine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Perphenazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Perphenazine :

Use Perphenazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Perphenazine may be taken with or without food.
• If you miss a dose of Perphenazine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Perphenazine .

Important safety information:

• Perphenazine may cause drowsiness, dizziness, or fainting. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Perphenazine . Using Perphenazine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Perphenazine . Perphenazine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Perphenazine may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
• Perphenazine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Perphenazine . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• Do not become overheated in hot weather or during exercise or other activities; heatstroke may occur.
• Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with Perphenazine . Symptoms may include increased body heat; rigid muscles; altered mental abilities, including lack of response to your surroundings; fast or irregular heartbeat; sweating. Contact your doctor at once if any of these symptoms occur.
• Involuntary and uncontrollable movements may develop in patients taking Perphenazine . Occurrence is highest among the elderly, especially women. The risk of developing these involuntary movements and the likelihood they will become permanent are increased with long-term use and with high doses. However it is possible to develop these symptoms after short-term treatment at low doses. Contact your health care provider at once if any of the following occur: involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Perphenazine .
• LAB TESTS, including liver and kidney function and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Perphenazine with caution in the ELDERLY because they may be more sensitive to its effects.
• Perphenazine is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is unknown if Perphenazine can cause harm to the fetus. If you become pregnant while taking Perphenazine , discuss with your doctor the benefits and risks of using Perphenazine during pregnancy. Perphenazine is excreted in breast milk. If you are or will be breast-feeding while you are using Perphenazine , check with your doctor or pharmacist to discuss the risks to your baby.

If you suddenly stop using Perphenazine , you may experience WITHDRAWAL symptoms, including dizziness, nausea, shakiness, upset stomach, and vomiting.

Possible side effects of Perphenazine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; blurred vision; confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; nasal congestion; nausea; sleeplessness; tired feeling; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; changes in vision or other vision problems; chest pain; difficulty speaking; difficulty swallowing; fainting; fast, slow, or irregular heartbeat; fever; inability to move eyes; inability to urinate; involuntary movements of the tongue, face, mouth, or jaw; lip smacking or puckering; mask-like face; mental confusion; muscle spasms of face, neck, or back; numbness of the arms and legs; prolonged or painful erection; puffing of cheeks; restlessness; seizures; severe stomach pain; shuffling walk or stiff arms or legs; sore throat; tension in leg; tightness in the throat or jaw; tremors of hands; twitching or twisting movements; unusual or excessive sweating; weakness of arms or legs; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; fast or irregular heartbeat; muscle spasms; restlessness; seizures; tremors; twitching.

Store Perphenazine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Perphenazine out of the reach of children and away from pets.

General information:

• If you have any questions about Perphenazine , please talk with your doctor, pharmacist, or other health care provider.
• Perphenazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Perphenazine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.