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|Perindopril

Perindopril

Perindopril is used for:

Treating high blood pressure. It may also be used to treat other conditions as determined by your doctor.

Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking ACE, an enzyme involved in narrowing blood vessels and causing sodium and fluid retention by the kidneys. This causes blood vessels to relax, allowing blood to flow more freely and at a lower pressure, and increasing the heart"s ability to pump blood in some types of heart failure.

Do NOT use Perindopril if:

• you are allergic to any ingredient in Perindopril
• you are in the second or third trimester of pregnancy
• you have a history of giant hives or skin inflammation caused by ACE inhibitors
• you are taking or have taken dextran sulfate within the past 3 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Perindopril :

Some medical conditions may interact with Perindopril . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of giant hives or skin inflammation, or hardening of the skin or organs
• if you have bone marrow depression, blood vessel problems in the brain (including stroke), or severe immune system disease
• if you are undergoing dialysis
• if you have high blood potassium, low blood sodium, or are on a sodium-restricted diet
• if you have ischemic heart disease, liver or kidney problems (including transplant), or lupus, or you are dehydrated

Some MEDICINES MAY INTERACT with Perindopril . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Indomethacin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or salicylates (eg, aspirin) because the effectiveness of Perindopril may be decreased
• Clozapine, cyclosporine, dextran sulfate, HMG-CoA reductase inhibitors (eg, simvastatin), indomethacin, mannitol, NSAIDs (eg, ibuprofen), pergolide, phenothiazines (eg, chlorpromazine), potassium, potassium-sparing diuretics (eg, triamterene), thiazide-type diuretics (eg, hydrochlorothiazide), or trimethoprim because the actions and side effects of Perindopril and these medicines may be increased
• Iron, lithium, sulfonylureas (eg, glyburide), or thiopurines (eg, azathioprine) because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Perindopril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Perindopril :

Use Perindopril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• You may take Perindopril on an empty stomach or with food.
• Take Perindopril regularly to receive the most benefit from it. Taking Perindopril at the same times(s) each day will help you to remember to take it. Continue taking Perindopril even if you feel well.
• If you miss a dose of Perindopril , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Perindopril .

Important safety information:

• Perindopril may cause dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Perindopril . Using Perindopril alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Dizziness or lightheadedness may occur if you stand up too fast from a lying or sitting position. Avoid sudden changes in posture.
• Drink plenty of fluids while taking Perindopril and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.
• A persistent, unproductive cough may occur. Tell your doctor if this occurs. Recovery is rapid when the medicine is stopped.
• Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking our medicine even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms.
• Black patients are at higher risk for certain side effects, and may not respond as well to Perindopril as patients of other races.
• Before you have any medical or dental treatments, emergency care, or surgery, tell your doctor or dentist that you are taking this medicine.
• Perindopril may lower your resistance to infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch you eyes or the inside of your nose unless you have thoroughly washed your hands first.
• Do not use salt substitutes containing potassium without first talking with your health care provider.
• It may take several weeks for Perindopril to work. Do not stop taking Perindopril without checking with your health care provider.
• LAB TESTS, including liver function, kidney function, blood pressure, blood counts, and blood electrolytes, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Caution is advised when using Perindopril in the ELDERLY because they may be more sensitive to its effects, especially dizziness and rash.
• Use Perindopril with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Perindopril has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Perindopril during pregnancy. It is unknown if Perindopril is excreted in breast milk. Do not breast-feed while taking Perindopril .

Possible side effects of Perindopril :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensation; arm or leg pain; back pain; cough; depression; diarrhea; dizziness; drowsiness; headache; lightheadedness; nausea; runny nose; weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine; chest pain; darkening of urine; difficulty swallowing; fainting; fast or irregular heartbeat; fever; hoarseness; pounding in the chest; prolonged nausea, vomiting, or diarrhea; severe lightheadedness or fainting; sore throat; swelling of the hands, legs, face, lips, eyes, throat, tongue, or trunk; unusual joint pain; unusual muscle pain, cramps, or weakness; unusual stomach pain; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dizziness; fainting; low blood pressure; weakness.

Store Perindopril at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, light, and moisture. Keep Perindopril out of the reach of children and away from pets.

General information:

• If you have any questions about Perindopril , please talk with your doctor, pharmacist, or other health care provider.
• Perindopril is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Perindopril . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.