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Endocet, Narvox, Percocet 10/650, Percocet 2.5/325, Percocet 5/325, Roxicet, Roxilox, Tylox, |Percocet 10/650

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Percocet 10/650

Generic Name: acetaminophen and oxycodone (a seet a MIN o fen and ox ee KOE done)
Brand Names: Endocet, Narvox, Percocet 10/650, Percocet 2.5/325, Percocet 5/325, Roxicet, Roxilox, Tylox

What is acetaminophen and oxycodone?

Oxycodone is in a group of drugs called narcotic pain relievers. It is similar to codeine.

Acetaminophen is a less potent pain reliever that increases the effects of oxycodone.

The combination of acetaminophen and oxycodone is used to relieve moderate to severe pain.

Acetaminophen and oxycodone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about acetaminophen and oxycodone?

Do not take acetaminophen and oxycodone with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Tell your doctor if you drink more than three alcoholic beverages per day or if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

Oxycodone may be habit-forming and should be used only by the person it was prescribed for. Acetaminophen and oxycodone should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Keep track of how many pills have been used from each new bottle of this medicine. Oxycodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Never take more acetaminophen and oxycodone than is prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

You may have withdrawal symptoms when you stop using this medication after using it over a long period of time. Do not stop using acetaminophen and oxycodone suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

What should I discuss with my healthcare provider before taking acetaminophen and oxycodone?

Do not use this medication if you are allergic to acetaminophen (Tylenol) or oxycodone (Oxycontin), or other narcotic pain relievers such as fentanyl (Actiq, Duragesic), hydrocodone (Vicodin), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph, and others), or oxymorphone (Opana).

Before using acetaminophen and oxycodone, tell your doctor if you are allergic to any drugs, or if you have:

asthma, COPD, sleep apnea, or other breathing disorders;
liver disease;
kidney disease;
underactive thyroid;
a history of head injury or brain tumor;
epilepsy or other seizure disorder;
low blood pressure;
a stomach or intestinal disorder;
Addison"s disease or other adrenal gland disorders;
enlarged prostate, urination problems;
mental illness; or
a history of drug or alcohol addiction.

If you have any of these conditions, you may not be able to use acetaminophen and oxycodone, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Acetaminophen and oxycodone may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to anyone younger than 18 years old.

Older adults may be more sensitive to the effects of this medicine.

How should I take acetaminophen and oxycodone?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

An overdose of acetaminophen can cause serious harm. The maximum amount of acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more acetaminophen could cause damage to your liver. One acetaminophen and oxycodone tablet may contain up to 650 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

If your medicine contains 650 mg of acetaminophen per tablet, take no more than 6 tablets in 24 hours. If your medicine contains 500 mg or less of acetaminophen, take no more than 8 tablets in 24 hours. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Take this medicine with a full glass of water. You may take the medication with food or milk if it causes stomach upset.

Measure the liquid form of this medication with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking acetaminophen and oxycodone. Ask your doctor about ways to increase the fiber in your diet. Do not use a stool softener (laxative) without first asking your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using acetaminophen and oxycodone. You may need to stop using the medicine for a short time.

You may have withdrawal symptoms when you stop using this medication after using it over a long period of time. Do not stop taking acetaminophen and oxycodone suddenly without first talking to your doctor. You may need to take less and less before you stop the medication completely. Store acetaminophen and oxycodone at room temperature away from moisture and heat.

What happens if I miss a dose?

Since acetaminophen and oxycodone is sometimes used as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of acetaminophen and oxycodone can be fatal.

Symptoms of an acetaminophen and oxycodone overdose may include extreme drowsiness, sweating, nausea, vomiting, low fever, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes), confusion, cold and clammy skin, shallow breathing, slow heart rate, fainting, or coma.

What should I avoid while taking acetaminophen and oxycodone?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not use any other over-the-counter cough, cold, allergy, or pain medication without first asking your doctor or pharmacist. Acetaminophen is contained in many cold and pain medicines available over the counter. If you take certain products together you may accidentally take too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen. Do not drink alcohol while you are taking acetaminophen and oxycodone. Dangerous side effects or death can occur when alcohol is combined with oxycodone. Do not take acetaminophen and oxycodone with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Acetaminophen and oxycodone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion, unusual thoughts or behavior;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to occur, such as:

drowsiness;
nausea, vomiting, constipation;
dizziness, headache; or
skin rash or itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect acetaminophen and oxycodone?

Before taking this medication, tell your doctor if you are using any of the following drugs:

atropine (Donnatal, and others), benztropine (Cogentin), methscopolamine (Pamine) or scopolamine (Transderm-Scop);
glycopyrrolate (Robinul);
bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva); or
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

If you are using any of these drugs, you may not be able to use acetaminophen and oxycodone, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect acetaminophen and oxycodone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about acetaminophen and oxycodone written for health professionals that you may read.

What does my medication look like?

Acetaminophen and oxycodone is available with a prescription under the brand names Tylox, Percocet, and Roxicet. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 7.03. Revision Date: 04/11/2007 2:50:53 PM.

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