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|Pentamidine Solution

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Pentamidine Solution

Generic Name: Pentamidine Inhalation Solution (pen-TAM-i-deen)
Brand Name: Nebupent

Pentamidine Solution is used for:

Preventing Pneumocystis jiroveci pneumonia (PCP) in high-risk HIV patients. It may also be used for other conditions as determined by your doctor.

Pentamidine Solution is an antiprotozoal agent. Exactly how Pentamidine Solution works in unknown.

Do NOT use Pentamidine Solution if:

you are allergic to any ingredient in Pentamidine Solution
you are taking cisapride, dofetilide, an H₁ antagonist (eg, astemizole, terfenadine), ibutilide, sparfloxacin, zalcitabine, or ziprasidone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pentamidine Solution:

Some medical conditions may interact with Pentamidine Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have heart problems (eg, irregular heartbeat), high or low blood pressure, blood problems (eg, anemia, low levels of white blood cells or platelets), low level of calcium in the blood, or liver, kidney, or pancreas problems
if you have diabetes or high or low blood sugar
if you are dehydrated
if you have a history of breathing or lung problems (eg, asthma), smoking, or PCP
if you have a history of Stevens-Johnson syndrome (red, swollen, blistered, peeling skin)

Some MEDICINES MAY INTERACT with this medicine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Arsenic, cisapride, dofetilide, H₁ antagonists (eg, astemizole, terfenadine), ibutilide, ketolides (eg, telithromycin), macrolides (eg, erythromycin), sparfloxacin, or ziprasidone because the risk of side effects such as irregular heartbeat may be increased
Zalcitabine because the risk of pancreas side effects may be increased
Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cisplatin, cyclosporine, foscarnet, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pentamidine Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pentamidine Solution:

Use Pentamidine Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Pentamidine Solution is usually administered as an inhalation at your doctor"s office, hospital, or clinic. If you are using Pentamidine Solution at home, carefully follow the inhalation procedures taught to you by your health care provider.
Pentamidine Solution should be mixed with 6 mL sterile water immediately before use unless you are directed otherwise by your doctor.
When using Pentamidine Solution, continue to inhale it until the entire chamber is empty (around 30 to 45 minutes) unless directed otherwise by your doctor.
Pentamidine Solution should only be inhaled using the Respirgard II nebulizer.
Do not mix Pentamidine Solution with any other medicines. Do not use the Respirgard II nebulizer to administer any other medicines.
Continue to use Pentamidine Solution even if you feel well. Do not miss any doses.
If you miss a dose of Pentamidine Solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Pentamidine Solution.

Important safety information:

Pentamidine Solution may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pentamidine Solution. Using Pentamidine Solution alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
You may still develop PCP even if you are using Pentamidine Solution. Contact your doctor or other health care provider immediately if you develop difficulty breathing, cough, or fever.
Pentamidine Solution may cause low blood sugar (eg, increased heartbeat, headache, chills, sweating, tremor, increased hunger, changes in vision, nervousness, weakness, dizziness, drowsiness, fainting) or high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, fruity breath odor). If these symptoms occur, tell your doctor immediately.
Use Pentamidine Solution with extreme caution in CHILDREN younger than 17 years of age. Safety and effectiveness in this age group have not been confirmed.
PREGNANCY and BREAST-FEEDING: It is unknown if Pentamidine Solution can cause harm to the fetus. If you become pregnant while taking Pentamidine Solution, discuss with your doctor the benefits and risks of using Pentamidine Solution during pregnancy. It is unknown if Pentamidine Solution is excreted in breast milk. If you are or will be breast-feeding while you are using Pentamidine Solution, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Pentamidine Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in mouth; cough; decreased appetite; diarrhea; dizziness; headache; nausea; night sweats; sinus inflammation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; dark urine; fast or irregular heartbeat; fever, chills, or sore throat; herpes infection (eg, shingles); increased or decreased urination; increased thirst; mental or mood changes; one-sided weakness; pounding in the chest; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness, nausea, or cough; shortness of breath; slurred speech; stomach pain; unusual bruising or bleeding; unusual tiredness or weakness; wheezing; white patches in the mouth or throat; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include chest pain; decreased urination; severe or persistent dizziness; yellowing of the skin or eyes.

Proper storage of Pentamidine Solution:

Store Pentamidine Solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). After mixing, Pentamidine Solution may be store at room temperature in the original vial for 48 hours if protected from light. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pentamidine Solution out of the reach of children and away from pets.

General information:

If you have any questions about Pentamidine Solution, please talk with your doctor, pharmacist, or other health care provider.
Pentamidine Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Pentamidine Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006

Database Edition 06.4.1.002

Where can I get more information about Pentamidine Solution ? We recommend to use www.Drugs.com

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