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ERYTHROMYCIN AND SULFISOXAZOLE (Systemic)
Some commonly used brand names are:
In the U.S.—
Generic name product may be available in the U.S.
Erythromycin and sulfisoxazole (er-ith-roe-MYE-sin and sul-fi-SOX-a-zole) is a combination antibiotic used to treat ear infections in children. It also may be used for other problems as determined by your doctor. It will not work for colds, flu, or other virus infections.
Erythromycin and sulfisoxazole combination is available only with your doctor"s prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For erythromycin and sulfisoxazole, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to the erythromycins or sulfa medicines, furosemide (e.g., Lasix) or thiazide diuretics (water pills), oral antidiabetics (diabetes medicine you take by mouth), or glaucoma medicine you take by mouth (for example, acetazolamide [e.g., Diamox], dichlorphenamide [e.g., Daranide], methazolamide [e.g., Neptazane]). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Studies have not been done in humans with either erythromycins or sulfa medicines. In addition, erythromycins have not been shown to cause birth defects or other problems in humans. However, studies in mice, rats, and rabbits have shown that some sulfa medicines cause birth defects, including cleft palate and bone problems.
Breast-feeding—Erythromycins and sulfa medicines pass into the breast milk. This medicine is not recommended for use during breast-feeding. It may cause liver problems, anemia, and other unwanted effects in nursing babies, especially those with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Children—This medicine has been tested in children over the age of 2 months and has not been shown to cause different side effects or problems than it does in adults. This medicine should not be given to infants under 2 months of age unless directed by the child"s doctor, because it may cause unwanted effects.
Older adults—This medicine is intended for use in children and is not generally used in adult patients.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking erythromycin and sulfisoxazole, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of erythromycin and sulfisoxazole. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Erythromycin and sulfisoxazole combination is best taken with extra amounts of water and may be taken with food. Additional amounts of water should be taken several times every day , unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (e.g., kidney stones) of sulfa medicines.
Do not give this medicine to infants under 2 months of age , unless otherwise directed by your doctor. Sulfa medicines may cause liver problems in these infants.
Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.
Do not use after the expiration date on the label. The medicine may not work properly after that date. Check with your pharmacist if you have any questions about this.
To help clear up your infection completely, keep taking this medicine for the full time of treatment , even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night . For example, if you are to take 4 doses a day, the doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.
Dosing—The dose of erythromycin and sulfisoxazole combination will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of erythromycin and sulfisoxazole combination. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—If you miss a dose of this medicine, take it as soon as possible. This will help to keep a constant amount of medicine in the blood. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
Storage—To store this medicine:
Precautions While Using This Medicine
It is very important that your doctor check you at regular visits for any blood problems that may be caused by this medicine, especially if you will be taking this medicine for a long time.
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
Erythromycin and sulfisoxazole may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:
If you have a severe reaction from the sun, check with your doctor .
Erythromycin and sulfisoxazole combination may cause blood problems. These problems may result in a greater chance of infection, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Itching; skin rash
Aching of joints and muscles; difficulty in swallowing; nausea or vomiting; pale skin; redness, blistering, peeling, or loosening of skin; skin rash; sore throat and fever; stomach pain, severe; unusual bleeding or bruising; unusual tiredness or weakness; yellow eyes or skin
Blood in urine; dark or amber urine; irregular or slow heartbeat; temporary loss of hearing (with kidney disease and high doses); lower back pain; pain or burning while urinating; pale stools; recurrent fainting; severe stomach pain; swelling of front part of neck
In addition to the side effects listed above, check with your doctor as soon as possible if the following side effect occurs:
Increased sensitivity to sunlight
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Abdominal or stomach cramping and discomfort; diarrhea; headache; loss of appetite; nausea or vomiting
Sore mouth or tongue
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not specifically included in product labeling, erythromycin and sulfisoxazole combination is used in certain patients with the following medical condition:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use.
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