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|PCE

PCE

PCE is used for:

Treating infections caused by certain bacteria. It is also used to prevent bacterial endocarditis and attacks of rheumatic fever. It may also be used for other conditions as determined by your doctor.

PCE is a macrolide antibiotic. Macrolide antibiotics slow the growth of, or sometimes kill, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

Do NOT use PCE if:

• you are allergic to any ingredient in PCE
• you are taking astemizole, cisapride, cyclosporine, diltiazem, dofetilide, ergot alkaloids (eg, ergotamine), HIV protease inhibitors (eg, ritonavir), imidazoles (eg, ketoconazole), pimozide, QT prolonging agents (eg, quinidine, sotalol), quinolones (eg, ciprofloxacin), streptogramins (eg, quinupristin/dalfopristin), sumatriptan, terfenadine, or verapamil

Contact your doctor or health care provider right away if any of these apply to you.

Before using PCE :

Some medical conditions may interact with PCE . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have diarrhea or a stomach or intestinal infection
• if you have a history of kidney or liver disease, heart problems, fast or irregular heartbeat, myasthenia gravis, or the blood disorder porphyria

Some MEDICINES MAY INTERACT with PCE . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Efavirenz or rifampin because they may decrease PCE "s effectiveness
• Arsenic, cimetidine,diltiazem,dofetilide,HIV protease inhibitors (eg, ritonavir), imidazoles (eg, ketoconazole), pimozide,QT-prolonging agents (eg, quinidine, sotalol), quinolones (eg, ciprofloxacin), streptogramins (eg, quinupristin/dalfopristin ), or verapamil because side effects, such as heart toxicity or irregular heartbeat, may occur
• Anticoagulants (eg, warfarin), aldosterone blockers (eg, spironolactone), alfentanil, arsenic, astemizole, benzodiazepines (eg, alprazolam), bromocriptine, buspirone, carbamazepine, cilostazol, cisapride, clozapine, corticosteroids (eg, hydrocortisone), cyclosporine, digitoxin, digoxin, disopyramide, ergot alkaloids (eg, ergotamine), felodipine, H₁ antagonists (eg, diphenhydramine), HMG-CoA reductase inhibitors (eg, lovastatin), imatinib, macrolide immunosuppressants (eg, tacrolimus), meglitinide antidiabetics (eg, repaglinide), midazolam, phosphodiesterase type 5 inhibitors (eg, sildenafil), pimozide, QT-prolonging agents (eg, quinidine, sotalol), quinolones (eg, ciprofloxacin), rifampin, serotonin reuptake inhibitors (eg, fluoxetine), sumatriptan, theophyllines, tricyclic antidepressants (eg, amitriptyline), valproic acid, or vinca alkaloids (eg, vincristine) because the risk of their side effects may increased by PCE

This may not be a complete list of all interactions that may occur. Ask your health care provider if PCE may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use PCE :

Use PCE as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Take PCE by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Swallow PCE whole. Do not break, crush, or chew before swallowing.
• Do not eat grapefruit or drink grapefruit juice while you use PCE .
• PCE works best if taken at the same times each day.
• To clear up your infection completely, take PCE for the full course of treatment. Keep taking it even if you feel better in a few days.
• If you miss a dose of PCE , take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use PCE .

Important safety information:

• Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
• PCE only works against bacteria; it does not treat viral infections (eg, the common cold).
• Be sure to use PCE for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of PCE may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use PCE . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using PCE while you are pregnant. PCE is found in breast milk. If you are or will be breast-feeding while you use PCE , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of PCE :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; loss of appetite; nausea; stomach pain; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; hearing changes; irregular heartbeat; red, swollen, or blistered skin; severe diarrhea; severe stomach pain or cramps; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store PCE at room temperature, below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep tightly closed. Keep PCE out of the reach of children and away from pets.

General information:

• If you have any questions about PCE , please talk with your doctor, pharmacist, or other health care provider.
• PCE is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about PCE . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.