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|Pancuronium Bromide |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Pancuronium BromidePronouncation: (PAN-cue-ROW-nee-uhm BROE-mide)Class: Nondepolarizing neuromuscular blocker Trade Names: Mechanism of ActionPharmacologyBinds competitively to cholinergic receptors on motor end-plate to antagonize action of acetylcholine, resulting in block of neuromuscular transmission. PharmacokineticsDistributionVd is 241 to 280 mL/kg. Plasma protein binding is 87%; strong binding to gamma globulin and moderate to albumin. MetabolismHepatic to active 3-hydroxy metabolite, which is half as potent a blocking agent as pancuronium. Other less potent metabolites include 17-hydroxy metabolite and 3,17-dihydroxy metabolite. EliminationUrine (40% as unchanged), bile (11% as metabolites). The t 1/ 2 is 89 to 161 min. Plasma Cl is approximately 1.1 to 1.9 mL/min/kg. Special PopulationsRenal Function ImpairmentElimination t ½ doubles, plasma Cl reduces 60%, and Vd may be elevated and variable. Hepatic Function ImpairmentIn patients with cirrhosis, the Vd increases approximately 50%, plasma Cl decreases 22%, and elimination t ½ doubles. Biliary obstructionPlasma Cl decreases 50%, Vd increases approximately 50%, and elimination t ½ doubles. Indications and UsageAdjunct to general anesthesia for induction of skeletal muscle relaxation; facilitation of management of patients undergoing mechanical ventilation; facilitation of tracheal intubation. ContraindicationsStandard considerations. Dosage and AdministrationIndividualize dose to each case. Endotracheal IntubationAdults and children older than 1 mo of age IV bolus 0.06 to 0.1 mg/kg. Skeletal muscle relaxation usually occurs in 2 to 3 min. Newborns younger than 1 mo of ageIV For test dose, use 0.02 mg/kg. Surgical ProceduresAdults and children older than 1 mo of age IV 0.04 to 0.1 mg/kg initially. For maintenance therapy, use incremental doses q 25 to 60 min beginning with 0.01 mg/kg. Newborns younger than 1 mo of ageIV For test dose, use 0.02 mg/kg. General Advice
Storage/StabilityStore undiluted product in refrigerator (36° to 46°F) to maintain potency for 24 mo, or at controlled room temperature (65° to 72°F) to maintain potency for 6 mo. Diluted solution is stable for 48 hr at controlled room temperature. Drug InteractionsAminoglycosides, bacitracin, clindamycin, colymycin, inhalational anesthetics, ketamine, lincomycin, magnesium salts, polymyxin B, quinidine, quinine, succinylcholine, tetracyclines, vancomycinMay augment action of pancuronium. Azathioprine, mercaptopurineMay cause reversal of neuromuscular blocking effects of pancuronium. Carbamazepine, hydantoinsMay decrease duration and effect of pancuronium. Halothane/tricyclic antidepressantsPatients receiving chronic TCA therapy who are anesthetized with halothane should use pancuronium with caution; severe ventricular arrhythmias may result. TheophyllinesMay cause possible resistance to, or reversal of, effects of pancuronium; cardiac arrhythmias may occur. TrimethaphanMay cause prolonged apnea. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularRise in arterial pressure, cardiac output, and heart rate. Decrease in central venous pressure. DermatologicTransient rash. GISalivation. RespiratoryRespiratory insufficiency; apnea. MiscellaneousSkeletal muscle weakness to complete relaxation; hypersensitivity reactions (eg, bronchospasm, flushing, redness, hypotension, tachycardia). Precautions
PregnancyCategory C ; do not use in early pregnancy. ChildrenProlonged use in newborns undergoing mechanical ventilation has been associated with severe skeletal muscle weakness and methemoglobinemia. Contains benzyl alcohol, which is related to a fatal gasping syndrome in premature infants. Labor and DeliveryReduce dosage in cesarean section if patient is receiving magnesium sulfate. Renal FunctionRenally excreted; may require lower doses or less frequent maintenance doses. Altered circulation time (eg, elderly patients, patients with CV disease or edema)Delay in onset of action. Electrolyte imbalanceNeuromuscular blockade may be altered depending on nature of imbalance. Hepatic or biliary tract diseaseResults in slower onset and prolonged duration. Myasthenia gravisSmall doses may have profound effects. Obesity/Neuromuscular diseaseRequire special attention to airway maintenance and ventilatory support. Pain/AnxietyPancuronium does not have analgesic or antianxiety effects. Paralyzed patient will still need analgesic or sedative agents if indicated. OverdosageSymptomsSkeletal muscle relaxation, decreased respiratory reserve, low tidal volume, apnea, prolonged neuromuscular blockade. Patient Information
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