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Generic Name: Palifermin (pal-ee-FER-min)
Brand Name: Kepivance

Palifermin is used for:

Reducing and treating mouth sores in patients who are receiving chemotherapy and radiation to treat lymphoma and other blood-related cancers.

Palifermin is a protein, keratinocyte growth factor. It works by increasing cell growth and healing of skin tissue.

Do NOT use Palifermin if:

  • you are allergic to any ingredient in Palifermin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Palifermin :

Some medical conditions may interact with Palifermin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are scheduled to receive chemotherapy within 24 hours
  • if you have any non-blood-related cancer

Some MEDICINES MAY INTERACT with Palifermin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Heparin because the effectiveness of Palifermin may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Palifermin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Palifermin :

Use Palifermin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Palifermin is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Palifermin at home, carefully follow the injection procedures taught to you by your health care provider.
  • Do not use Palifermin within 24 hours of certain chemotherapy because the effectiveness of Palifermin may be decreased.
  • If you miss a dose of Palifermin , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Palifermin .

Important safety information:

  • Because Palifermin works by increasing cell growth of skin and certain other tissues, it may increase growth of any tumor not related to the blood.
  • Use Palifermin with caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if Palifermin can cause harm to the fetus. If you become pregnant while taking Palifermin , discuss with your doctor the benefits and risks of using Palifermin during pregnancy. It is unknown if Palifermin is excreted in breast milk. If you are or will be breast-feeding while you are using Palifermin , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Palifermin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in taste; joint pain; skin reactions (rash, irritation, redness, swelling, itching); tingling, numbness, prickling, or burning sensation around the mouth or on the skin; tongue thickening or discoloration.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately.

Proper storage of Palifermin :

Palifermin is usually handled and stored by a health care provider. If you are using Palifermin at home, store Palifermin as directed by your pharmacist or health care provider. Keep Palifermin out of the reach of children and away from pets.

General information:

  • If you have any questions about Palifermin , please talk with your doctor, pharmacist, or other health care provider.
  • This medicine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Palifermin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

Where can I get more information about Palifermin ? We recommend to use

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