Nystatin Suspension


|Nystatin Suspension

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Nystatin Suspension

Generic Name: nystatin
Dosage Form: Powder for oral suspension

Nystatin Suspension Description

Nystatin USP is an antifungal antibiotic obtained from Streptomyces noursei. It is known to be a mixture, but the composition has not been completely elucidated. Nystatin A is closely related to amphotericin B. Each is a macrocyclic lactone containing a ketal ring, an all-trans polyene system, and a mycosamine (3-amino-3-deoxy-rhamnose) moiety. Nystatin A has a molecular formula of C47H75NO17 and a molecular weight of 926.11.

Nystatin USP is a ready-to-use, non-sterile powder for oral administration which contains no excipients or preservatives. It is available in containers of 50 million, 150 million, 500 million, and 2 billion units. Each mg contains a minimum of 5,000 units.

Nystatin Suspension - Clinical Pharmacology

Nystatin probably acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components. It is absorbed very sparingly following oral administration, with no detectable blood levels when given in the recommended doses. Most of the orally administered nystatin is passed unchanged in the stool.


For the treatment of intestinal and oral cavity infections caused by Candida (Monilia) albicans.


Hypersensitivity to the drug.

Adverse Reactions

Large oral doses of nystatin have occasionally produced diarrhea, gastrointestinal distress, and possible irritation of the stomach that may result in nausea and vomiting.

Nystatin Suspension Dosage and Administration


Adults and older children: Add approximately 500,000 units of Nystatin USP to about 1/2 cup of water and stir well. 500,000 units of Nystatin USP is equivalent to the recommended dose for adults and children of Nystatin Oral Suspension (4 to 6 mL, or 400,000 to 600,000 units). This product contains no preservatives and therefore should be used immediately after mixing and should not be stored. It is designed for extemporaneous preparation of a single dose at a time.

Infections of the oral cavity caused by Candida (Monilia) albicans:

Infants: 200,000 units four times daily.

Children and adults: 400,000 to 600,000 units four times daily (one-half dose in each side of mouth).

NOTE: Limited clinical studies in premature and low birth-weight infants indicate that 100,000 units four times daily is effective.

Local treatment should be continued at least 48 hours after perioral symptoms have disappeared and cultures returned to normal.

It is recommended that the drug be retained in the mouth as long as possible before swallowing.

Intestinal candidiasis (moniliasis)

Usual dosage: 500,000 to 1 million units three times daily. Treatment should generally be continued for at least 48 hours after clinical cure to prevent relapse.

How is Nystatin Suspension Supplied

Nystatin USP is supplied in containers of 50 million, 150 million, 500 million, and 2 billion units.

Product Code
Approx. Weight
0574-0404-05 50 million 8.3 - 10
0574-0404-15 150 million 25 - 30
0574-0404-50 500 million 83 - 100
0574-0404-02 2 billion 333 - 400

Storage: Store in a refrigerator, 2°-8°C (36°-46°F). Protect from light. Dispense in a tight, light-resistant container.

NOTE: The potency of this product cannot be assured for longer than 90 days after the container is first opened.

Packaged by:
Paddock Laboratories, Inc.
Minneapolis, MN 55427


Nystatin (Nystatin)
Product Code 0574-0404 Dosage Form POWDER, FOR SUSPENSION
Route Of Administration ORAL DEA Schedule
Name (Active Moiety) Type Strength
Nystatin (Nystatin) Active 5000 UNITS  In 1 MILLIGRAM
Characteristic Appearance Characteristic Appearance
Color Score
Shape Symbol
Imprint Code Coating
# NDC Package Description Multilevel Packaging
1 0574-0404-50 100 GRAM In 1 BOTTLE, PLASTIC None
2 0574-0404-05 10 GRAM In 1 BOTTLE, PLASTIC None
3 0574-0404-15 30 GRAM In 1 BOTTLE, PLASTIC None
4 0574-0404-02 400 GRAM In 1 BOTTLE, PLASTIC None

Revised: 02/2006

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