|Nabumetone Nabumetone

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Generic name: Nabumetone
Brand names: Relafen

Why is Nabumetone prescribed?

Nabumetone, a nonsteroidal anti-inflammatory drug, is used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis (the most common form of arthritis).

Most important fact about Nabumetone

You should have frequent checkups with your doctor if you take Nabumetone regularly. Ulcers or internal bleeding can occur with or without warning.

How should you take Nabumetone?

Nabumetone can be taken with or without food. Take it exactly as prescribed.

--If you miss a dose...

Take the forgotten dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take a double dose.

--Storage instructions...

Keep Nabumetone in the container it came in, tightly closed, and away from moist places and direct light. It can be stored at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine whether it is safe for you to continue taking Nabumetone.

  • More common side effects may include:
    Abdominal pain, constipation, diarrhea, dizziness, fluid retention, gas, headache, indigestion, itching, nausea, rash, ringing in ears

Why should Nabumetone not be prescribed?

Do not take Nabumetone if you are sensitive to or have ever had an allergic reaction to Nabumetone, or if you have had asthma attacks, hives or other allergic reactions caused by Nabumetone, aspirin, or other nonsteroidal anti-inflammatory drugs.

Special warnings about Nabumetone

Stomach and intestinal ulcers can occur without warning. Remember to get regular checkups.

Make sure the doctor knows if you have kidney or liver disease. Nabumetone should be used with caution.

This drug can cause fluid retention and swelling. It should be used with caution if you have congestive heart failure or high blood pressure.

Nabumetone can cause increased sensitivity to sunlight.

Possible food and drug interactions when taking Nabumetone

If Nabumetone is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Nabumetone with blood-thinning drugs such as Coumadin and aspirin.

Other drugs with which Nabumetone could possibly interact include:

Diuretics such as HydroDIURIL and Lasix
Lithium (Eskalith)

Special information if you are pregnant or breastfeeding

The effects of Nabumetone during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Nabumetone may appear in breast milk and could affect a nursing infant. If Nabumetone is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Nabumetone is finished.

Recommended dosage


The usual starting dose is 1000 milligrams taken as a single dose. Dosage may be increased up to 2000 milligrams per day, taken once or twice a day.


The safety and effectiveness of Nabumetone in children have not been established.


Overdoses of nonsteroidal anti-inflammatory drugs such as Nabumetone have been known to cause stomach bleeding, elevated blood pressure, kidney failure, impaired breathing, and coma, though these effects are rare.

  • Warning signs of overdose include:
    Drowsiness,, lack of energy, nausea, vomiting, stomach pain

If you suspect an overdose, seek medical attention immediately.

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