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|Mytrex

NYSTATIN AND TRIAMCINOLONE (Topical)†

Some commonly used brand names are:

In the U.S.—

• Dermacomb
• Myco II
• Mycobiotic II
• Mycogen II
• Mycolog II
• Myco-Triacet II
• Mykacet
• Mykacet II
• Mytrex
• Tristatin II

Generic name product may be available in the U.S.

† Not commercially available in Canada.

Category

• Antifungal-corticosteroid, topical

Description

Nystatin and triamcinolone (nye-STAT-in and trye-am-SIN-oh-lone ) combination contains an antifungal and a corticosteroid (kor-ti-co-STER-oid) (cortisone-like medicine).

Antifungals are used to treat infections caused by a fungus. They work by killing the fungus or preventing its growth. This medicine will not work for other kinds of infections. Corticosteroids belong to the family of medicines called steroids. They are used to help relieve redness, swelling, itching, and other discomfort of many skin problems.

This medicine is used to treat certain fungus infections, such as Candida (Monilia), and to help relieve the discomfort of the infection.

Topical corticosteroids may rarely cause some serious side effects. Some of the side effects may be more likely to occur in children. Before using this medicine in children, be sure to talk to your doctor about these problems, as well as the good this medicine may do .

Nystatin and triamcinolone combination is available only with your doctor"s prescription, in the following dosage forms:

• Topical
• Cream (U.S.)
• Ointment (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nystatin and triamcinolone combination, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to nystatin or triamcinolone. Also tell your health care professional if you are allergic to any other substances, such as preservatives or dyes.

Pregnancy—Nystatin and triamcinolone combination has not been studied in pregnant women. However, studies in animals have shown that corticosteroids given by mouth or by injection may cause birth defects, even at low doses. Also, some of the stronger corticosteroids have been shown to cause birth defects when applied to the skin of animals. Therefore, this medicine should not be used on large areas of skin, in large amounts, or for a long time in pregnant patients. Before using this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether nystatin or triamcinolone passes into the breast milk. Although this combination medicine has not been reported to cause problems in humans, topical corticosteroids may be absorbed into the body. Corticosteroids that are given by mouth or by injection do pass into the breast milk and may cause unwanted effects, such as interfering with nursing babies" growth.

Children—Children may be especially sensitive to the effects of topical nystatin and triamcinolone combination. This may increase the chance of side effects during treatment. Therefore, it is especially important that you discuss with your child"s doctor the good that this medicine may do as well as the risks of using it.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of topical nystatin and triamcinolone combination in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are using nystatin and triamcinolone combination, it is especially important that your health care professional know if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The presence of other medical problems may affect the use of nystatin and triamcinolone combination. Make sure you tell your doctor if you have any other medical problems, especially:

• Herpes

• Vaccinia (cowpox)

• Varicella (chickenpox)

• Other virus infections of the skin—Triamcinolone may speed up the spread of virus infections

• Tuberculosis (TB) of the skin—Triamcinolone may make a TB infection worse

Proper Use of This Medicine

Do not use this medicine in or around the eyes .

Check with your doctor before using this medicine on any other skin problems . It should not be used on bacterial or virus infections. Also, it should only be used on certain fungus infections of the skin.

Apply a thin layer of this medicine to the affected area and rub in gently and thoroughly.

The use of any kind of airtight covering over this medicine may increase absorption of the medicine and the chance of irritation and other side effects. Therefore, do not bandage, wrap, or apply any airtight covering or other occlusive dressing (for example, kitchen plastic wrap) over this medicine unless directed to do so by your doctor. Also, wear loose-fitting clothing when using this medicine on the groin area. When using this medicine on the diaper area of children, avoid tight-fitting diapers and plastic pants .

To help clear up your infection completely, keep using this medicine for the full time of treatment , even if your symptoms have disappeared. Do not miss any doses . However, do not use this medicine more often or for a longer time than your doctor ordered . To do so may increase absorption through your skin and the chance of side effects. In addition, too much use, especially on thin skin areas (for example, face, armpits, groin), may result in thinning of the skin and stretch marks.

Dosing—The dose of topical nystatin and triamcinolone combination will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of topical nystatin and triamcinolone combination. If your dose is different, do not change it unless your doctor tells you to do so.

• For fungus infections:
  • For cream dosage form:
    • Adults and children—Apply to the affected area(s) of the skin two times a day, morning and evening
  • For ointment dosage form:
    • Adults and children—Apply to the affected area(s) of the skin two or three times a day.

Missed dose—If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Keep the medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

To help clear up your infection completely and to help make sure it does not return, good health habits are also required . Keep the affected area as cool and dry as possible.

If your skin problem does not improve within 2 or 3 weeks, or if it becomes worse, check with your doctor.

The corticosteroid in this medicine may be absorbed through the skin and may be more likely to cause side effects in children. Long-term use may affect growth and development as well. Children who must use this medicine should be followed closely by their doctor .

For diabetic patients:

• Although rare, the corticosteroid in this medicine may cause higher blood and urine sugar levels, especially if you have severe diabetes and are using large amounts of this medicine . Check with your doctor before changing your diet or the dosage of your diabetes medicine.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Additional side effects may occur if you use this medicine for a long time. Check with your doctor as soon as possible if any of the following side effects occur:

Acne or oily skin; increased hair growth, especially on the face; increased loss of hair, especially on the scalp; reddish purple lines on arms, face, legs, trunk, or groin; thinning of skin with easy bruising

Many of the above side effects are more likely to occur in children, who may absorb greater amounts of this medicine.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 08/15/1994

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