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Mirapex, |Mirapex

Mirapex

Generic Name: pramipexole (oral) (pram i PEX ole)
Brand Names: Mirapex

What is pramipexole?

Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson"s disease.

Pramipexole is used to treat symptoms of Parkinson"s disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Pramipexole is also used to treat restless legs syndrome (RLS).

Pramipexole may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about pramipexole?

If you are taking this medication for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms.

Dizziness or drowsiness may be more likely to occur when you rise from a sitting or lying position. Rise slowly and use caution to prevent a fall.

Avoid using other medicines that make you sleepy (such as alcohol, cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by pramipexole.

Pramipexole may cause hallucinations (the sensation of hearing or seeing something that is not there), most commonly among elderly people. Call your doctor if you have hallucinations.

What should I discuss with my healthcare provider before taking pramipexole?

Before using pramipexole, tell your doctor if you are allergic to any drugs, or if you have:

• narcolepsy (a sleep disorder);

• kidney disease; or

• tremors (dyskinesia) or uncontrolled muscle movements.

If you have any of these conditions, you may not be able to use pramipexole, or you may need a dosage adjustment or special tests during treatment.

How should I take pramipexole?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

The dose and timing of pramipexole in treating Parkinson"s disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label.

If you are taking this medication for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Symptoms of a pramipexole overdose are not known.

What should I avoid while taking pramipexole?

Avoid using other medicines that make you sleepy (such as alcohol, cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by pramipexole.

Dizziness or drowsiness may be more likely to occur when you rise from a sitting or lying position. Rise slowly and use caution to prevent a fall.

Pramipexole side effects

• extreme drowsiness, falling asleep suddenly, even after feeling alert;

• hallucinations;

• fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;

• nausea, sweating, feeling light-headed, fainting; or

• restless muscle movements in your eyes, tongue, jaw, or neck.

Continue taking pramipexole if you have any of these less serious side effects:

• constipation, upset stomach, loss of appetite;

• dry mouth, trouble swallowing;

• urinating more often than usual;

• mild drowsiness or sleepiness;

• sleep problems (insomnia), unusual dreams;

• amnesia, forgetfulness, thinking problems;

• headache, confusion, weakness;

• blurred vision;

• joint pain, muscle weakness;

• swelling in your hands or feet;

• runny or stuffy nose;

• weight loss; or

• impotence, loss of interest in sex, or trouble having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect pramipexole?

Before taking pramipexole, tell your doctor if you are using any of the following drugs:

• amantadine (Symmetrel);

• cimetidine (Tagamet);

• diltiazem (Cardizem, Cartia, Dilacor, Tiazac);

• ranitidine (Zantac);

• quinidine (Quinaglute, Quinidex);

• quinine(Qualaquin);

• triamterine (Dyrenium); or

• verapamil (Calan, Covera, Isoptin).

If you are using any of these drugs, you may not be able to use pramipexole, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect pramipexole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about pramipexole written for health professionals that you may read.

What do my pills look like?

Pramipexole is available with a prescription under the brand name Mirapex. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Mirapex 0.125 mg-white, round tablets

• Mirapex 0.25 mg-white, oval, scored tablets

• Mirapex 1.0 mg-white, round, scored tablets

• Mirapex 1.5 mg-white, round, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and only use this medication for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.