Minizide

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Minizide


Generic Name: Polythiazide/Prazosin (pol-i-THYE-a-zide/PRA-zoe-sin)
Brand Name: Minizide

Minizide is used for:

Treating high blood pressure. It may also be used for other conditions as determined by your doctor.

Minizide is an alpha-blocker and thiazide diuretic combination. It works by widening blood vessels and helping the kidneys eliminate extra fluid from your body, which helps lower blood pressure.

Do NOT use Minizide if:

  • you are allergic to any ingredient in Minizide or to any other sulfonamide medicine (eg sulfamethoxazole, glyburide, acetazolamide)
  • you are unable to urinate
  • you are taking dofetilide, ketanserin, a phosphodiesterase type 5 inhibitor (eg, sildenafil, tadalafil, vardenafil), or modafinil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Minizide :

Some medical conditions may interact with Minizide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have gout, kidney or liver problems, lupus, diabetes, asthma, parathyroid problems, high blood cholesterol or lipid levels, chest pain, heart problems, narcolepsy, or low blood pressure
  • if you have low blood sodium, chloride, potassium, or magnesium levels; or high blood calcium levels
  • if you have recently had nerve surgery

Some MEDICINES MAY INTERACT with Minizide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, indomethacin) because they decrease the effectiveness of Minizide
  • Barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), corticotropin (ACTH), medicines for high blood pressure, narcotic pain medicines (eg, codeine, morphine, fentanyl), or verapamil because side effects of Minizide may be increased
  • Diazoxide or nondepolarizing muscle relaxants (eg, tubocurarine) because side effects may be increased by Minizide
  • Lithium because risk of toxicity may be increased by Minizide
  • Beta-blockers (eg, propranolol), bupivacaine, digoxin, dofetilide, ketanserin, nifedipine, or phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil , vardenafil) because side effects of these medicines may be increased
  • Diabetes medicines (eg, glipizide, metformin), insulin, or modafinil because their effectiveness may be decreased by Minizide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Minizide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Minizide :

Use Minizide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Minizide may be taken with or without food.
  • When you first start taking Minizide , it may cause an increase in urine or in frequency of urination. To prevent this from affecting sleep, try not to take any dose later than 6 pm.
  • Continue to use Minizide even if you feel well. Do not miss any doses.
  • Taking Minizide at the same time each day will help you remember to take it.
  • Take Minizide regularly to receive the most benefit from it.
  • If you miss a dose of Minizide , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Minizide .

Important safety information:

  • Minizide may cause dizziness, drowsiness, lightheadedness, fainting, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Minizide . Using Minizide alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Minizide may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Minizide .
  • Minizide may cause high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor). If these symptoms occur, tell your doctor immediately.
  • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
  • Minizide may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Minizide . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking your medication even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms.
  • LAB TESTS, including kidney function, blood pressure, and blood electrolyte levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Minizide with caution in the ELDERLY because they may be more sensitive to its effects.
  • Minizide is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Minizide during pregnancy. Minizide is excreted in breast milk. Do not breast-feed while taking Minizide .

Possible side effects of Minizide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; flushing; headache; lightheadedness, especially when sitting up or standing; numbness or tingling of skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; changes in sexual function; confusion; decrease in amount of urine; drowsiness; fainting; gout; muscle pain or cramps; rapid or irregular heartbeat; red, swollen, blistered, or peeling skin; restlessness; seizures; shortness of breath; stomach pain; unusual thirst; unusual tiredness or weakness; unusually dry mouth; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dry mouth; excessive urination followed by a decrease in amount of urine; muscle cramps; severe lightheadedness, especially upon standing; weak or irregular heartbeat.

Proper storage of Minizide :

Store Minizide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Minizide out of the reach of children and away from pets.

General information:

  • If you have any questions about Minizide , please talk with your doctor, pharmacist, or other health care provider.
  • Minizide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Minizide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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