Midodrine Hydrochloride

drug-information.ru

|Midodrine Hydrochloride

Drugs search, click the first letter of a drug name:


| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9  Home

Midodrine Hydrochloride

Pronouncation: (mid-OH-drean HIGH-droe-KLOR-ide)
Class: Vasopressor

Trade Names:
ProAmatine
- Tablets 2.5 mg
- Tablets 5 mg
- Tablets 10 mg

Mechanism of Action

Pharmacology

Activates arteriolar and venous α-adrenergic receptors, resulting in an increase in vascular tone and elevation of BP.

Pharmacokinetics

Absorption

Midodrine is rapidly absorbed. Absolute bioavailability is 93%, prodrug T max is 30 min, and metabolite T max is 1 to 2 hr.

Distribution

Neither prodrug nor metabolite is bound to plasma proteins to any significant extent.

Metabolism

Major active metabolite is desglymidodrine. Declycination of midodrine to desglymidodrine takes place in many tissues. Both compounds are metabolized in part by the liver.

Elimination

Renal Cl of desglymidodrine is 385 mL/min (approximately 80% by active renal secretion). The t ½ is 25 min (midodrine) and 3 to 4 hr (desglymidodrine).

Peak

Time to peak is 1 hr.

Duration

Duration is 2 to 3 hr.

Special Populations

Renal Function Impairment

Use cautiously in patients with urinary retention problems. A lower starting dose (2.5 mg) may be necessary. Assess renal function prior to initial use.

Hepatic Function Impairment

Use with caution, as the liver has a role in the metabolism.

Indications and Usage

Treatment of symptomatic orthostatic hypotension in patients whose lives are considerably impaired despite standard clinical care, including support stockings, fluid expansion, and lifestyle changes.

Unlabeled Uses

Management of urinary incontinence.

Contraindications

Severe organic heart disease, acute renal failure, urinary retention, phenochromocytoma, thyrotoxicosis, or in patients with persistent and excessive supine hypertension.

Dosage and Administration

Adults

PO 10 mg tid during daytime hours.

Renal Function Impairment
Adults

PO Start with 2.5 mg/dose.

Storage/Stability

Store tablets at controlled room temperature (59° to 86°F).

Drug Interactions

Alpha-blocking agents (eg, prazosin, terazosin, doxazosin)

May antagonize pressor effects of midodrine.

Cardiac glycosides (ie, digitalis), beta-blockers

May precipitate bradycardia, AV block, or arrhythmia.

Fludrocortisone

May exacerbate supine hypertension.

Vasoconstrictors (eg, dihydroergotamine, ephedrine, phenylephrine, phenylpropanolamine, pseudoephedrine)

May enhance pressor effects of midodrine.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Supine and sitting hypertension (7%); bradycardia.

CNS

Paresthesia (18%); headache; confusion; nervousness; anxiety; confusion; abnormal thinking.

Dermatologic

Piloerection (13%); scalp pruritus (12%); rash (2%).

GI

Abdominal pain; dry mouth.

Genitourinary

Dysuria (frequency, impaired micturition, urinary retention, urinary urgency) (13%).

Miscellaneous

Pain, chills (5%); facial flushing; feeling of fullness/pressure in head.

Precautions

Warnings

Hypertension

Because the drug can cause significant hypertension, use only in patients whose lives are considerably impaired despite critical care. Clinical benefits have not been verified.


Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established.

Renal Function

Use with caution. Initiate therapy with smaller doses.

Hepatic Function

Use with caution.

Bradycardia

May occur because of vagal reflex. Use caution when coadministering with other agents that can reduce heart rate (eg, cardiac glycosides, beta-blockers, psychopharmacologic agents).

Diabetes

Use with caution.

Supine hypertension

Potentially most serious adverse reaction. Most common in patients with elevated pretreatment supine systolic BP (mean 170 mm Hg). Use is not recommended in patients with pretreatment supine systolic BP above 180 mm Hg. Monitor supine and sitting BPs.

Urinary retention

Use with caution because of effect on α-adrenergic receptors of bladder neck.

Overdosage

Symptoms

Hypertension, piloerection, sensation of coldness, urinary retention.

Patient Information

  • Explain name, dose, action, and potential side effects of drug.
  • Advise patient to read the Patient Information leaflet before starting therapy and with each refill.
  • Ensure that patient understands dosing schedule and importance of taking last dose more than 4 hr before bedtime to minimize supine hypertension.
  • Advise patient to take as prescribed and not to stop taking or change the dose unless advised by health care provider.
  • Advise patient to take each dose without regard to meals but to take with food if stomach upset occurs.
  • Advise patient to skip dose before lying down for any length of time (eg, nap).
  • Ensure that patient has, and can use, a home BP monitoring device. Advise patient to monitor and record BP and pulse at regular intervals and in lying, sitting, and standing positions. Advise patient to inform health care provider if persistent hypertension noted or if heart rate is persistently slow.
  • Advise patient to sleep with head of bed elevated if supine hypertension noted.
  • Advise patient to discontinue therapy and notify health care provider immediately if any of the following occur: cardiac awareness, pounding in the ears, headache, blurred vision, slowing of heart rate, dizziness, fainting.
  • Advise patient that abnormal skin sensations, goosebumps, itching, and painful or difficult urination are most common side effects and to inform health care provider if these or any other unexplained sensation or feeling occur and are bothersome.
  • Advise patient to inform health care provider of any unexplained feeling or sensation.
  • Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.
  • Caution patient not to take any prescription or OTC drugs or dietary supplements without consulting health care provider.
  • Advise patient that follow-up visits and lab tests may be necessary to monitor therapy and to keep appointments.




Where can I get more information about Midodrine Hydrochloride ? We recommend to use www.Drugs.com

Typical mistypes for Midodrine Hydrochloride
nidodrine hydrochloride, kidodrine hydrochloride, jidodrine hydrochloride, mudodrine hydrochloride, mjdodrine hydrochloride, mkdodrine hydrochloride, mododrine hydrochloride, m9dodrine hydrochloride, m8dodrine hydrochloride, misodrine hydrochloride, mixodrine hydrochloride, micodrine hydrochloride, mifodrine hydrochloride, mirodrine hydrochloride, mieodrine hydrochloride, mididrine hydrochloride, midkdrine hydrochloride, midldrine hydrochloride, midpdrine hydrochloride, mid0drine hydrochloride, mid9drine hydrochloride, midosrine hydrochloride, midoxrine hydrochloride, midocrine hydrochloride, midofrine hydrochloride, midorrine hydrochloride, midoerine hydrochloride, midodeine hydrochloride, midoddine hydrochloride, midodfine hydrochloride, midodtine hydrochloride, midod5ine hydrochloride, midod4ine hydrochloride, midodrune hydrochloride, midodrjne hydrochloride, midodrkne hydrochloride, midodrone hydrochloride, midodr9ne hydrochloride, midodr8ne hydrochloride, midodribe hydrochloride, midodrime hydrochloride, midodrije hydrochloride, midodrihe hydrochloride, midodrinw hydrochloride, midodrins hydrochloride, midodrind hydrochloride, midodrinr hydrochloride, midodrin4 hydrochloride, midodrin3 hydrochloride, midodrine gydrochloride, midodrine bydrochloride, midodrine nydrochloride, midodrine jydrochloride, midodrine uydrochloride, midodrine yydrochloride, midodrine htdrochloride, midodrine hgdrochloride, midodrine hhdrochloride, midodrine hudrochloride, midodrine h7drochloride, midodrine h6drochloride, midodrine hysrochloride, midodrine hyxrochloride, midodrine hycrochloride, midodrine hyfrochloride, midodrine hyrrochloride, midodrine hyerochloride, midodrine hydeochloride, midodrine hyddochloride, midodrine hydfochloride, midodrine hydtochloride, midodrine hyd5ochloride, midodrine hyd4ochloride, midodrine hydrichloride, midodrine hydrkchloride, midodrine hydrlchloride, midodrine hydrpchloride, midodrine hydr0chloride, midodrine hydr9chloride, midodrine hydroxhloride, midodrine hydrovhloride, midodrine hydrofhloride, midodrine hydrodhloride, midodrine hydrocgloride, midodrine hydrocbloride, midodrine hydrocnloride, midodrine hydrocjloride, midodrine hydroculoride, midodrine hydrocyloride, midodrine hydrochkoride, midodrine hydrochporide, midodrine hydrochooride, midodrine hydrochliride, midodrine hydrochlkride, midodrine hydrochllride, midodrine hydrochlpride, midodrine hydrochl0ride, midodrine hydrochl9ride, midodrine hydrochloeide, midodrine hydrochlodide, midodrine hydrochlofide, midodrine hydrochlotide, midodrine hydrochlo5ide, midodrine hydrochlo4ide, midodrine hydrochlorude, midodrine hydrochlorjde, midodrine hydrochlorkde, midodrine hydrochlorode, midodrine hydrochlor9de, midodrine hydrochlor8de, midodrine hydrochlorise, midodrine hydrochlorixe, midodrine hydrochlorice, midodrine hydrochlorife, midodrine hydrochlorire, midodrine hydrochloriee, midodrine hydrochloridw, midodrine hydrochlorids, midodrine hydrochloridd, midodrine hydrochloridr, midodrine hydrochlorid4, midodrine hydrochlorid3, idodrine hydrochloride, mdodrine hydrochloride, miodrine hydrochloride, middrine hydrochloride, midorine hydrochloride, midodine hydrochloride, midodrne hydrochloride, midodrie hydrochloride, midodrin hydrochloride, midodrinehydrochloride, midodrine ydrochloride, midodrine hdrochloride, midodrine hyrochloride, midodrine hydochloride, midodrine hydrchloride, midodrine hydrohloride, midodrine hydrocloride, midodrine hydrochoride, midodrine hydrochlride, midodrine hydrochloide, midodrine hydrochlorde, midodrine hydrochlorie, midodrine hydrochlorid, imdodrine hydrochloride, mdiodrine hydrochloride, mioddrine hydrochloride, middorine hydrochloride, midordine hydrochloride, midodirne hydrochloride, midodrnie hydrochloride, midodrien hydrochloride, midodrin ehydrochloride, midodrineh ydrochloride, midodrine yhdrochloride, midodrine hdyrochloride, midodrine hyrdochloride, midodrine hydorchloride, midodrine hydrcohloride, midodrine hydrohcloride, midodrine hydroclhoride, midodrine hydrocholride, midodrine hydrochlroide, midodrine hydrochloirde, midodrine hydrochlordie, midodrine hydrochloried, mmidodrine hydrochloride, miidodrine hydrochloride, middodrine hydrochloride, midoodrine hydrochloride, midoddrine hydrochloride, midodrrine hydrochloride, midodriine hydrochloride, midodrinne hydrochloride, midodrinee hydrochloride, midodrine hydrochloride, midodrine hhydrochloride, midodrine hyydrochloride, midodrine hyddrochloride, midodrine hydrrochloride, midodrine hydroochloride, midodrine hydrocchloride, midodrine hydrochhloride, midodrine hydrochlloride, midodrine hydrochlooride, midodrine hydrochlorride, midodrine hydrochloriide, midodrine hydrochloridde, midodrine hydrochloridee, etc.



© Copyright by drug-information.ru 2001-2019. All rights reserved