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|Midodrine Hydrochloride |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Midodrine HydrochloridePronouncation: (mid-OH-drean HIGH-droe-KLOR-ide)Class: Vasopressor Trade Names: Mechanism of ActionPharmacologyActivates arteriolar and venous α-adrenergic receptors, resulting in an increase in vascular tone and elevation of BP. PharmacokineticsAbsorptionMidodrine is rapidly absorbed. Absolute bioavailability is 93%, prodrug T max is 30 min, and metabolite T max is 1 to 2 hr. DistributionNeither prodrug nor metabolite is bound to plasma proteins to any significant extent. MetabolismMajor active metabolite is desglymidodrine. Declycination of midodrine to desglymidodrine takes place in many tissues. Both compounds are metabolized in part by the liver. EliminationRenal Cl of desglymidodrine is 385 mL/min (approximately 80% by active renal secretion). The t ½ is 25 min (midodrine) and 3 to 4 hr (desglymidodrine). PeakTime to peak is 1 hr. DurationDuration is 2 to 3 hr. Special PopulationsRenal Function ImpairmentUse cautiously in patients with urinary retention problems. A lower starting dose (2.5 mg) may be necessary. Assess renal function prior to initial use. Hepatic Function ImpairmentUse with caution, as the liver has a role in the metabolism. Indications and UsageTreatment of symptomatic orthostatic hypotension in patients whose lives are considerably impaired despite standard clinical care, including support stockings, fluid expansion, and lifestyle changes. Unlabeled UsesManagement of urinary incontinence. ContraindicationsSevere organic heart disease, acute renal failure, urinary retention, phenochromocytoma, thyrotoxicosis, or in patients with persistent and excessive supine hypertension. Dosage and AdministrationAdultsPO 10 mg tid during daytime hours. Renal Function ImpairmentAdults PO Start with 2.5 mg/dose. Storage/StabilityStore tablets at controlled room temperature (59° to 86°F). Drug InteractionsAlpha-blocking agents (eg, prazosin, terazosin, doxazosin)May antagonize pressor effects of midodrine. Cardiac glycosides (ie, digitalis), beta-blockersMay precipitate bradycardia, AV block, or arrhythmia. FludrocortisoneMay exacerbate supine hypertension. Vasoconstrictors (eg, dihydroergotamine, ephedrine, phenylephrine, phenylpropanolamine, pseudoephedrine)May enhance pressor effects of midodrine. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularSupine and sitting hypertension (7%); bradycardia. CNSParesthesia (18%); headache; confusion; nervousness; anxiety; confusion; abnormal thinking. DermatologicPiloerection (13%); scalp pruritus (12%); rash (2%). GIAbdominal pain; dry mouth. GenitourinaryDysuria (frequency, impaired micturition, urinary retention, urinary urgency) (13%). MiscellaneousPain, chills (5%); facial flushing; feeling of fullness/pressure in head. Precautions
PregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established. Renal FunctionUse with caution. Initiate therapy with smaller doses. Hepatic FunctionUse with caution. BradycardiaMay occur because of vagal reflex. Use caution when coadministering with other agents that can reduce heart rate (eg, cardiac glycosides, beta-blockers, psychopharmacologic agents). DiabetesUse with caution. Supine hypertensionPotentially most serious adverse reaction. Most common in patients with elevated pretreatment supine systolic BP (mean 170 mm Hg). Use is not recommended in patients with pretreatment supine systolic BP above 180 mm Hg. Monitor supine and sitting BPs. Urinary retentionUse with caution because of effect on α-adrenergic receptors of bladder neck. OverdosageSymptomsHypertension, piloerection, sensation of coldness, urinary retention. Patient Information
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