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ProAmatine, |midodrine Midodrine

midodrine

Generic Name: midodrine (MY doe drin)
Brand Names: ProAmatine

What is midodrine?

Midodrine is a vasopressor. Midodrine causes constriction (tightening) of the blood vessels which leads to an increase in blood pressure.

Midodrine is used to treat low blood pressure.

Midodrine may also be used for purposes other than those listed here.

What is the most important information I should know about midodrine?

Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least 3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.

Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.

What should I discuss with my healthcare provider before taking midodrine?

• heart or blood vessel problems (other than low blood pressure);

• high blood pressure;

• kidney problems;

• difficulty urinating;

• pheochromocytoma; or

• over active thyroid.

Before taking this medication, tell your doctor if you have

• liver problems;

• visual disturbances;

• diabetes; or

• glaucoma.

You may not be able to take midodrine, or you may require a dosage adjustment or special monitoring during treatment.

How should I take midodrine?

Take midodrine exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse, or pharmacist to explain them to you.

Midodrine can be taken with or without food.

Take midodrine at regular intervals as directed by your doctor.

Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least 3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.

Your doctor may want you to have regular blood pressure monitoring or other medical evaluations during treatment with midodrine to monitor progress and side effects.

What happens if I miss a dose?

Take the missed dose as soon as you remember then wait the prescribed amount of time before taking another dose. Generally, doses should not be taken less than 3 hours apart. Follow your doctor"s instructions. Do not take a double dose of this medication, unless otherwise directed by your doctor.

What happens if I overdose?

Symptoms of a midodrine overdose may include increased blood pressure (flushing, headache, pounding heartbeat, blurred vision), goosebumps, difficulty urination, a feeling of being cold, and loss of consciousness.

What should I avoid while taking midodrine?

Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least 3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.

Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.

Midodrine side effects

• an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); or

• irregular heartbeats, fluttering feeling in the chest, or chest pain.

Other, less serious side effects may be more likely to occur. Continue to take midodrine and talk to your doctor if you experience

• chills or goosebumps;

• itching or tingling of the skin;

• increased need to urinate or difficulty with urination;

• feeling of pressure or fullness in the head;

• dryness of the mouth; or

• nervousness or anxiety.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect midodrine?

Before taking midodrine, talk to your doctor if you are taking any other medicines especially any of the following:

• an alpha adrenergic blocker such as alfuzosin (Uroxatral), doxazosin (Cardura), guanadrel (Hylorel), prazosin (Minipress), or terazosin (Hytrin);

• flecainide (Tambocor);

• cimetidine (Tagamet, Tagamet HB) or ranitidine (Zantac, Zantac 75);

• digoxin (Lanoxin);

• metformin (Glucophage);

• fludrocortisone (Florinef);

• triamterene (Dyrenium, Dyazide, Maxzide);

• drugs that stimulate alpha-adrenergic receptors such as pseudoephedrine, phenylephrine, ephedrine, or dihydroergotamine;

• quinidine (Quinaglute, Quinidex, Quin-Release); or

• procainamide (Procan SR, Procanbid, Pronestyl).

You may not be able to take midodrine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, irregular heartbeat medicines, or antidepressants without first talking to your doctor.

Drugs other than those listed here may also interact with midodrine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about midodrine written for health professionals that you may read.

What does my medication look like?

Midodrine is available with a prescription under the brand name ProAmantine. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• ProAmantine 2.5. mg-white, round, scored tablets

• ProAmantine 5 mg-orange, round, scored tablets

• ProAmantine 10 mg-blue, round, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.