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METRONIDAZOLE (Topical)

Some commonly used brand names are:

In the U.S.—

MetroCream
MetroGel
MetroLotion

In Canada—

MetroCream
MetroGel

Description

Topical metronidazole (me-troe-NI-da-zole) is applied to the skin in adults to help control rosacea (roe-ZAY-she-ah) , also known as acne rosacea and “adult acne.” This medicine helps to reduce the redness of the skin and the number of pimples, usually found on the face, in patients with rosacea.

Topical metronidazole is available only with your doctor"s prescription, in the following dosage forms:

Topical
Cream (U.S. and Canada)
Gel (U.S. and Canada)
Lotion (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For topical metronidazole, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to metronidazole, clotrimazole, or tioconazole. Also tell your health care professional if you are allergic to any other substances, such as preservatives or dyes.

Pregnancy—Topical metronidazole has not been studied in pregnant women. However, metronidazole given by mouth (e.g., Flagyl) has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding—Topical metronidazole is absorbed into the mother"s body only in small amounts. The small amounts of this medicine that are absorbed are unlikely to cause serious problems in nursing babies.

Children—Rosacea is usually considered an adult disease. Therefore, topical metronidazole is not generally used in children.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of topical metronidazole in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) medicine that is to be applied to the same area of the skin.

Other medical problems—The presence of other medical problems may affect the use of topical metronidazole. Make sure you tell your doctor if you have any other medical problems, especially:

Blood disease or a history of blood disease—Metronidazole may make the condition worse

Proper Use of This Medicine

Do not use this medicine in or near the eyes . Watering of the eyes may occur when the medicine is used too close to the eyes.

If this medicine does get into your eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

Before applying this medicine, thoroughly wash the affected area(s) with a mild, nonirritating cleanser, rinse well, and gently pat dry.

To use:

After washing the affected area(s), apply this medicine with your fingertips.
Apply and rub in a thin film of medicine, using enough to cover the affected area(s) lightly. You should apply the medicine to the whole area usually affected by rosacea, not just to the pimples themselves .
Wash the medicine off your hands.

To help keep your rosacea under control, keep using this medicine for the full time of treatment . You may have to continue using this medicine every day for 9 weeks or longer. Do not miss any doses .

Dosing—The dose of topical metronidazole will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of topical metronidazole. If your dose is different, do not change it unless your doctor tells you to do so.

For topical dosage forms (cream, gel, and lotion):
- For rosacea:
  - Adults—Apply to the affected area(s) of skin two times a day, morning and evening, for nine weeks.
  - Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage—To store this medicine:

Keep out of the reach of children.
Store away from heat and direct light.
Keep the medicine from freezing.
Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

If your rosacea does not improve within 3 weeks, or if it becomes worse, check with your doctor. However, treatment of rosacea may take up to 9 weeks or longer before you see full improvement.

Stinging or burning of the skin may be expected after this medicine is applied. These effects may last up to a few minutes or more. If irritation continues, check with your doctor. You may have to use the medicine less often or stop using it altogether. Follow your doctor"s directions.

You may continue to use cosmetics (make-up) while you are using this medicine for rosacea. However, it is best to use only “oil-free” cosmetics. Also, it is best not to use cosmetics too heavily or too often. They may make your rosacea worse. If you have any questions about this, check with your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. The following side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of these effects continue or are bothersome:

Less common

Dry skin; redness or other signs of skin irritation not present before use of this medicine; stinging or burning of the skin; watering of eyes

Rare

Metallic taste in the mouth; nausea; tingling or numbness of arms, legs, hands, or feet

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 12/22/1999

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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