Metoclopramide Injection USP
 Metoclopramide Oral Solution

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|Metoclopramide Injection USP Metoclopramide Oral Solution

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Metoclopramide

Dosage Form: Injection usp

Rx only

Metoclopramide Description

Metoclopramide Injection, USP (Metoclopramide hydrochloride) is a clear, colorless, sterile solution with a pH of 2.5 to 6.5 for intravenous or intramuscular administration.

This product is light sensitive. It should be inspected before use and discarded if either color or particulate is observed.

Each mL contains: Metoclopramide base 5 mg (as the monohydrochloride monohydrate), sodium chloride, USP 8.5 mg, Water for Injection, USP qs. Contains no preservative. pH adjusted, when necessary, with hydrochloric acid and/or sodium hydroxide.

Metoclopramide hydrochloride is a white, crystalline, odorless substance, freely soluble in water. Chemically, it is 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy benzamide monohydrochloride monohydrate. It has a molecular weight of 354.3, a molecular formula of C14H22ClN3O2•HCl•H2O and the following structural formula:

Metoclopramide - Clinical Pharmacology

Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Its mode of action is unclear. It seems to sensitize tissues to the action of acetylcholine. The effect of Metoclopramide on motility is not dependent on intact vagal innervation, but it can be abolished by anticholinergic drugs.

Metoclopramide increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any effect on the motility of the colon or gallbladder.

In patients with gastroesophageal reflux and low LESP (lower esophageal sphincter pressure), single oral doses of Metoclopramide produce dose-related increases in LESP. Effects begin at about 5 mg and increase through 20 mg (the largest dose tested). The increase in LESP from a 5 mg dose lasts about 45 minutes and that of 20 mg lasts between 2 and 3 hours. Increased rate of stomach emptying has been observed with single oral doses of 10 mg.

The antiemetic properties of Metoclopramide appear to be a result of its antagonism of central and peripheral dopamine receptors. Dopamine produces nausea and vomiting by stimulation of the medullary chemoreceptor trigger zone (CTZ), and Metoclopramide blocks stimulation of the CTZ by agents like l-dopa or apomorphine which are known to increase dopamine levels or to possess dopamine-like effects. Metoclopramide also abolishes the slowing of gastric emptying caused by apomorphine.

Like the phenothiazines and related drugs, which are also dopamine antagonists, Metoclopramide produces sedation and may produce extrapyramidal reactions, although these are comparatively rare (see WARNINGS). Metoclopramide inhibits the central and peripheral effects of apomorphine, induces release of prolactin and causes a transient increase in circulating aldosterone levels, which may be associated with transient fluid retention.

The onset of pharmacological action of Metoclopramide is 1 to 3 minutes following an intravenous dose and 10 to 15 minutes following intramuscular administration; pharmacological effects persist for 1 to 2 hours.

Pharmacokinetics: Metoclopramide is rapidly and well absorbed. Relative to an intravenous dose of 20 mg, the absolute oral bioavailability of Metoclopramide is 80% ± 15.5% as demonstrated in a crossover study of 18 subjects. Peak plasma concentrations occur at about 1-2 hrs after a single oral dose. Similar time to peak is observed after individual doses at steady state.

In a single dose study of 12 subjects, the area under the drug concentration-time curve increases linearly with doses from 20 to 100 mg. Peak concentrations increase linearly with dose; time to peak concentrations remains the same; whole body clearance is unchanged; and the elimination rate remains the same. The average elimination half-life in individuals with normal renal function is 5-6 hrs. Linear kinetic processes adequately describe the absorption and elimination of Metoclopramide.

Approximately 85% of the radioactivity of an orally administered dose appears in the urine within 72 hours. Of the 85% eliminated in the urine, about half is present as free or conjugated Metoclopramide.

The drug is not extensively bound to plasma proteins (about 30%). The whole body volume of distribution is high (about 3.5 L/kg) which suggests extensive distribution of drug to the tissues.

Renal impairment affects the clearance of Metoclopramide. In a study with patients with varying degrees of renal impairment, a reduction in creatinine clearance was correlated with a reduction in plasma clearance, renal clearance, non-renal clearance, and increase in elimination half-life. The kinetics of Metoclopramide in the presence of renal impairment remained linear however. The reduction in clearance as a result of renal impairment suggests that adjustment downward of maintenance dosage should be done to avoid drug accumulation.

Adult Pharmacokinetic Data

Parameter

Value

Vd (L/kg)

~ 3.5

Plasma Protein Binding

~ 30%

t1/2 (hr)

5-6

Oral Bioavailability

80%±15.5%

In pediatric patients, the pharmacodynamics of Metoclopramide following oral and intravenous administration are highly variable and a concentration-effect relationship has not been established.

There are insufficient reliable data to conclude whether the pharmacokinetics of Metoclopramide in adults and the pediatric population are similar. Although there are insufficient data to support the efficacy of Metoclopramide in pediatric patients with symptomatic gastroesophageal reflux (GER) or cancer chemotherapy-related nausea and vomiting, its pharmacokinetics have been studied in these patient populations.

In an open-label study, six pediatric patients (age range, 3.5 weeks to 5.4 months) with GER received Metoclopramide 0.15 mg/kg oral solution every 6 hours for 10 doses. The mean peak plasma concentration of Metoclopramide after the tenth dose was 2-fold (56.8 mcg/L) higher compared to that observed after the first dose (29 mcg/L) indicating drug accumulation with repeated dosing. After the tenth dose, the mean time to reach peak concentrations (2.2 hrs), half-life (4.1 hrs), clearance (0.67 L/h/kg), and volume of distribution (4.4 L/kg) of Metoclopramide were similar to those observed after the first dose. In the youngest patient (age, 3.5 weeks), Metoclopramide half-life after the first and the tenth dose (23.1 and 10.3 hrs, respectively) was significantly longer compared to other infants due to reduced clearance. This may be attributed to immature hepatic and renal systems at birth.

Single intravenous doses of Metoclopramide 0.22 to 0.46 mg/kg (mean, 0.35 mg/kg) were administered over 5 minutes to nine pediatric cancer patients receiving chemotherapy (mean age, 11.7 years; range, 7 to 14 yrs) for prophylaxis of cytotoxic-induced vomiting. The Metoclopramide plasma concentrations extrapolated to time zero ranged from 65 to 395 mcg/L (mean, 152 mcg/L). The mean elimination half-life, clearance, and volume of distribution of Metoclopramide were 4.4 hrs (range, 1.7 to 8.3 hrs), 0.56 L/h/kg (range, 0.12 to 1.20 L/h/kg), and 3.0 L/kg (range, 1.0 to 4.8 L/kg), respectively.

In another study, nine pediatric cancer patients (age range, 1 to 9 yrs) received 4 to 5 intravenous infusions (over 30 minutes) of Metoclopramide at a dose of 2 mg/kg to control emesis. After the last dose, the peak serum concentrations of Metoclopramide ranged from 1060 to 5680 mcg/L. The mean elimination half-life, clearance, and volume of distribution of Metoclopramide were 4.5 hrs (range, 2.0 to 12.5 hrs), 0.37 L/h/kg (range, 0.10 to 1.24 L/h/kg), and 1.93 L/kg (range, 0.95 to 5.50 L/kg), respectively.

Pediatric Pharmacokinetic Studies

Reference

Dose, Route

t1/2

(hr)

Cl

(L/hr/kg)

Vd

(L/kg)

Cmax

(mcg/L)

1.

0.35 mg/kg

IV over 5 min

4.4±0.56

0.56±0.10

3.0±0.38

(Dose/Cp0)

152±31

2.

2 mg/kg

30 min IV

infusion 4-5 times

within 9.5 hours

4.5a

0.37a

1.93a

1060 to 5680a

aSEM not available.

1. Bateman, DN, et al. Br J Clin Pharmac 15:557-559, 1983.

2. Ford, C. Clin Pharmac Ther 43:196, 1988.

Indications and Usage for Metoclopramide

Diabetic Gastroparesis (Diabetic Gastric Stasis). Metoclopramide Injection, USP is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis.

The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy. Metoclopramide Injection, USP is indicated for the prophylaxis of vomiting associated with emetogenic cancer chemotherapy.

The Prevention of Postoperative Nausea and Vomiting. Metoclopramide Injection, USP is indicated for the prophylaxis of postoperative nausea and vomiting in those circumstances where nasogastric suction is undesirable.

Small Bowel Intubation. Metoclopramide Injection, USP may be used to facilitate small bowel intubation in adults and pediatric patients in whom the tube does not pass the pylorus with conventional maneuvers.

Radiological Examination. Metoclopramide Injection, USP may be used to stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and/or small intestine.

Contraindications

Metoclopramide should not be used whenever stimulation of gastrointestinal motility might be dangerous, e.g., in the presence of gastrointestinal hemorrhage, mechanical obstruction, or perforation.

Metoclopramide is contraindicated in patients with pheochromocytoma because the drug may cause a hypertensive crisis, probably due to release of catecholamines from the tumor. Such hypertensive crises may be controlled by phentolamine.

Metoclopramide is contraindicated in patients with known sensitivity or intolerance to the drug.

Metoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactions, since the frequency and severity of seizures or extrapyramidal reactions may be increased.

Warnings

Mental depression has occurred in patients with and without prior history of depression. Symptoms have ranged from mild to severe and have included suicidal ideation and suicide. Metoclopramide should be given to patients with a prior history of depression only if the expected benefits outweigh the potential risks.

Extrapyramidal symptoms, manifested primarily as acute dystonic reactions, occur in approximately 1 in 500 patients treated with the usual adult dosages of 30 mg/day to 40 mg/day of Metoclopramide. These usually are seen during the first 24 to 48 hours of treatment with Metoclopramide, occur more frequently in pediatric patients and adult patients less than 30 years of age, and are even more frequent at the higher doses used in prophylaxis of vomiting due to cancer chemotherapy. These symptoms may include involuntary movements of limbs and facial grimacing, torticollis, oculogyric crisis, rhythmic protrusion of tongue, bulbar type of speech, trismus, or dystonic reactions resembling tetanus. Rarely, dystonic reactions may present as stridor and dyspnea, possibly due to laryngospasm. If these symptoms should occur, inject 50 mg Benadryl® (diphenhydramine hydrochloride) intramuscularly, and they usually will subside. Cogentin® (benztropine mesylate), 1 mg to 2 mg intramuscularly, may also be used to reverse these reactions.

Parkinsonian-like symptoms have occurred, more commonly within the first 6 months after beginning treatment with Metoclopramide, but occasionally after longer periods. These symptoms generally subside within 2 to 3 months following discontinuance of Metoclopramide. Patients with preexisting Parkinson"s disease should be given Metoclopramide cautiously, if at all, since such patients may experience exacerbation of parkinsonian symptoms when taking Metoclopramide.

Tardive Dyskinesia: Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with Metoclopramide. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to predict which patients are likely to develop the syndrome. Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase with the duration of treatment and the total cumulative dose.

Less commonly, the syndrome can develop after relatively brief treatment periods at low doses; in these cases, symptoms appear more likely to be reversible.

There is no known treatment for established cases of tardive dyskinesia although the syndrome may remit, partially or completely, within several weeks-to-months after Metoclopramide is withdrawn. Metoclopramide itself, however, may suppress (or partially suppress) the signs of tardive dyskinesia, thereby masking the underlying disease process. The effect of this symptomatic suppression upon the long-term course of the syndrome is unknown. Therefore, the use of Metoclopramide for the symptomatic control of tardive dyskinesia is not recommended.

Neuroleptic Malignant Syndrome (NMS): There have been rare reports of an uncommon but potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) associated with Metoclopramide. Clinical manifestations of NMS include hyperthermia, muscle rigidity, altered consciousness, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac arrhythmias).

The management of NMS should include 1) immediate discontinuation of Metoclopramide and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring, and 3) treatment of any concomitant serious medical problems for which specific treatments are available. Bromocriptine and dantrolene sodium have been used in treatment of NMS, but their effectiveness have not been established (see ADVERSE REACTIONS).

The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Other important considerationsin the differential diagnosis include central anticholinergic toxicity, heat stroke, malignant hyperthermia, drug fever and primary central nervous system (CNS) pathology.

Precautions

General.

In one study in hypertensive patients, intravenously administered Metoclopramide was shown to release catecholamines; hence, caution should be exercised when Metoclopramide is used in patients with hypertension.

Intravenous injections of undiluted Metoclopramide should be made slowly allowing 1 to 2 minutes for 10 mg since a transient but intense feeling of anxiety and restlessness, followed by drowsiness, may occur with rapid administration.

Because Metoclopramide produces a transient increase in plasma aldosterone, certain patients, especially those with cirrhosis or congestive heart failure, may be at risk of developing fluid retention and volume overload. If these side effects occur at any time during Metoclopramide therapy, the drug should be discontinued.

Intravenous administration of Metoclopramide Injection, USP, diluted in a parenteral solution should be made slowly over a period of not less than 15 minutes.

Giving a promotility drug such as Metoclopramide theoretically could put increased pressure on suture lines following a gut anastomosis or closure. This possibility should be considered and weighed when deciding whether to use Metoclopramide or nasogastric suction in the prevention of postoperative nausea and vomiting.

Information for Patients:

Metoclopramide may impair the mental and/or physical abilities required for the performance of hazardous tasks such as operating machinery or driving a motor vehicle. The ambulatory patient should be cautioned accordingly.

Drug Interactions:

The effects of Metoclopramide on gastrointestinal motility are antagonized by anticholinergic drugs and narcotic analgesics. Additive sedative effects can occur when Metoclopramide is given with alcohol, sedatives, hypnotics, narcotics or tranquilizers.

The finding that Metoclopramide releases catecholamines in patients with essential hypertension suggests that it should be used cautiously, if at all, in patients receiving monoamine oxidase inhibitors.

Absorption of drugs from the stomach may be diminished (e.g., digoxin) by Metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).

Gastroparesis (gastric stasis) may be responsible for poor diabetic control in some patients. Exogenously administered insulin may begin to act before food has left the stomach and lead to hypoglycemia. Because the action of Metoclopramide will influence the delivery of food to the intestines and thus the rate of absorption, insulin dosage or timing of dosage may require adjustment.

Carcinogenesis, Mutagenesis, Impairment of Fertility:

A 77-week study was conducted in rats with oral doses up to about 40 times the maximum recommended human daily dose. Metoclopramide elevates prolactin levels and the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin-dependent in vitro, a factor of potential importance if the prescription of Metoclopramide is contemplated in a patient with previously detected breast cancer. Although disturbances such as galactorrhea, amenorrhea, gynecomastia, and impotence have been reported with prolactin-elevating drugs, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of prolactin-stimulating neuroleptic drugs and Metoclopramide.

Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is too limited to be conclusive at this time.

An Ames mutagenicity test performed on Metoclopramide was negative.

Pregnancy. Teratogenic Effects. Pregnancy Category B:

Reproduction studies performed in rats, mice, and rabbits by the IV, IM, SC, and oral routes at maximum levels ranging from 12 to 250 times the human dose have demonstrated no impairment of fertility or significant harm to the fetus due to Metoclopramide. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing Mothers:

Metoclopramide is excreted in human milk. Caution should be exercised when Metoclopramide is administered to a nursing mother.

Pediatric Use:

Safety and effectiveness in pediatric patients have not been established except as stated to facilitate small bowel intubation (see OVERDOSAGE and DOSAGE AND ADMINISTRATION).

Care should be exercised in administering Metoclopramide to neonates since prolonged clearance may produce excessive serum concentrations (see CLINICAL PHARMACOLOGY− Pharmacokinetics). In addition, neonates have reduced levels of NADH-cytochrome b5 reductase which, in combination with the aforementioned pharmacokinetic factors, make neonates more susceptible to methemoglobinemia (see OVERDOSAGE).

The safety profile of Metoclopramide in adults cannot be extrapolated to pediatric patients. Dystonias and other extrapyramidal reactions associated with Metoclopramide are more common in the pediatric population than in adults (see WARNINGS and ADVERSE REACTIONS− Extrapyramidal Reactions.)

Geriatric Use:

Clinical studies of Metoclopramide did not include sufficient numbers of subjects aged 65 and over to determine whether elderly subjects respond differently from younger subjects.

The risk of developing parkinsonian-like side effects increases with ascending dose. Geriatric patients should receive the lowest dose of Metoclopramide that is effective. If parkinsonian-like symptoms develop in a geriatric patient receiving Metoclopramide, Metoclopramide should generally be discontinued before initiating any specific anti-parkinsonian agents (see WARNINGS and DOSAGE AND ADMINISTRATION─For the Relief of Symptomatic Gastroesophageal Reflux).

The elderly may be at greater risk for tardive dyskinesia (see WARNINGS-Tardive Dyskinesia).

Sedation has been reported in Metoclopramide users. Sedation may cause confusion and manifest as over-sedation in elderly (see CLINICAL PHARMACOLOGY, PRECAUTIONS─Information for Patients and ADVERSE REACTIONS─CNS Effects).

Metoclopramide is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function (see DOSAGE AND ADMINISTRATION─USE IN PATIENTS WITH RENAL OR HEPATIC IMPAIRMENT).

For these reasons, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased renal function, concomitant disease, or other drug therapy in the elderly (see DOSAGE AND ADMINISTRATION ─For the Relief of Symptomatic Gastroesophageal Reflux and USE IN PATIENTS WITH RENAL OR HEPATIC IMPAIRMENT).

Other Special Populations: Patients with NADH-cytochrome b5 reductase deficiency are at an increased risk of developing methemoglobinemia and/or sulfhemoglobinemia when Metoclopramide is administered. In patients with G6PD deficiency who experience Metoclopramide-induced methemoglobinemia, methylene blue treatment is not recommended (see OVERDOSAGE).

Adverse Reactions

In general, the incidence of adverse reactions correlates with the dose and duration of Metoclopramide administration. The following reactions have been reported, although in most instances, data do not permit an estimate of frequency.

CNS Effects: Restlessness, drowsiness, fatigue and lassitude may occur in patients receiving the recommended prescribed dose of Metoclopramide. Insomnia, headache, confusion, dizziness or mental depression with suicidal ideation also may occur (see WARNINGS). In cancer chemotherapy patients being treated with 1-2 mg/kg per dose incidence of drowsiness is about 70%. There are isolated reports of convulsive seizures without a clear-cut relationship to Metoclopramide. Rarely, hallucinations have been reported.

Extrapyramidal Reactions (EPS): Acute dystonic reactions, the most common type of EPS associated with Metoclopramide, occur in approximately 0.2% of patients (1 in 500) treated with 30 mg to 40 mg of Metoclopramide per day. In cancer chemotherapy patients receiving 1-2 mg/kg per dose, the incidence is 2% in patients over the ages of 30-35, and 25% or higher in pediatric patients and adult patients less than 30 years of age who have not had prophylactic administration of diphenhydramine. Symptoms include involuntary movements of limbs, facial grimacing, torticollis, oculogyric crisis, rhythmic protrusion of tongue, bulbar type of speech, trismus, opisthotonus (tetanus-like reactions) and rarely, stridor and dyspnea possibly due to laryngospasm; ordinarily these symptoms are readily reversed by diphenhydramine (see WARNINGS).

Parkinsonian-like symptoms may include bradykinesia, tremor, cogwheel rigidity, mask-like facies (see WARNINGS).

Tardive dyskinesia most frequently is characterized by involuntary movements of the tongue, face, mouth or jaw, and sometimes by involuntary movements of the trunk and/or extremities; movements may be choreoathetotic in appearance (see WARNINGS).

Motor restlessness (akathisia) may consist of feelings of anxiety, agitation, jitteriness, and insomnia, as well as inability to sit still, pacing, foot-tapping. These symptoms may disappear spontaneously or respond to a reduction in dosage.

Neuroleptic Malignant Syndrome: Rare occurrences of neuroleptic malignant syndrome (NMS) have been reported. This potentially fatal syndrome is comprised of the symptom complex of hyperthermia, muscular rigidity, altered consciousness, and autonomic instability (see WARNINGS).

Endocrine Disturbances: Galactorrhea, amenorrhea, gynecomastia, impotence secondary to hyperprolactinemia (see PRECAUTIONS). Fluid retention secondary to transient elevation of aldosterone (see CLINICAL PHARMACOLOGY).

Cardiovascular: Hypotension, hypertension, supraventricular tachycardia, bradycardia, fluid retention, acute congestive heart failure, and possible atrioventricular (AV) block (see CONTRAINDICATIONS and PRECAUTIONS).

Gastrointestinal: Nausea and bowel disturbances, primarily diarrhea.

Hepatic: Rarely, cases of hepatotoxicity, characterized by such findings as jaundice and altered liver function tests, when Metoclopramide was administered with other drugs with known hepatotoxic potential.

Renal: Urinary frequency and incontinence.

Hematologic: A few cases of neutropenia, leukopenia, or agranulocytosis, generally without a clear-cut relationship to Metoclopramide. Methemoglobinemia in adults and especially with overdosage in neonates (see OVERDOSAGE). Sulfhemoglobinemia in adults.

Allergic Reactions: A few cases of rash, urticaria, or bronchospasm, especially in patients with a history of asthma. Rarely, angioneurotic edema, including glossal or laryngeal edema.

Miscellaneous: Visual disturbances. Porphyria. Transient flushing of the face and upper body, without alterations in vital signs, following high doses intravenously.

Overdosage

Symptoms of overdosage may include drowsiness, disorientation and extrapyramidal reactions. Anticholinergic or antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactions. Symptoms are self-limiting and usually disappear within 24 hours.

Hemodialysis removes relatively little Metoclopramide, probably because of the small amount of the drug in blood relative to tissues. Similarly, continuous ambulatory peritoneal dialysis does not remove significant amounts of drug. It is unlikely that dosage would need to be adjusted to compensate for losses through dialysis. Dialysis is not likely to be an effective method of drug removal in overdose situations.

Unintentional overdose due to misadministration has been reported in infants and children with the use of Metoclopramide syrup. While there was no consistent pattern to the reports associated with these overdoses, events included seizures, extrapyramidal reactions, and lethargy.

Methemoglobinemia has occurred in premature and full-term neonates who were given overdoses of Metoclopramide (1 mg/kg/day to 4 mg/kg/day orally, intramuscularly or intravenously for 1 to 3 or more days). Methemoglobinemia can be reversed by the intravenous administration of methylene blue. However, methylene blue may cause hemolytic anemia in patients with G6PD deficiency, which may be fatal (see PRECAUTIONS─Other Special Populations).

Metoclopramide Dosage and Administration

For the Relief of Symptoms Associated with Diabetic Gastroparesis (Diabetic Gastric Stasis): If only the earliest manifestations of diabetic gastric stasis are present, oral administration of Metoclopramide may be initiated. However, if severe symptoms are present, therapy should begin with Metoclopramide (IM or IV). Doses of 10 mg may be administered slowly by the intravenous route over a 1 to 2 minute period.

Administration of Metoclopramide Injection, USP up to 10 days may be required before symptoms subside, at which time oral administration may be instituted.

For the Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy: For doses in excess of 10 mg, Metoclopramide Injection, USP should be diluted in 50 mL of a parenteral solution.

The preferred parenteral solution is Sodium Chloride Injection (normal saline), which when combined with Metoclopramide Injection, USP, can be stored frozen for up to 4 weeks. Metoclopramide Injection, USP is degraded when admixed and frozen with Dextrose-5% in Water. Metoclopramide Injection, USP diluted in Sodium Chloride Injection, Dextrose-5% in Water, Dextrose-5% in 0.45% Sodium Chloride, Ringer"s Injection, or Lactated Ringer"s Injection may be stored up to 48 hours (without freezing) after preparation if protected from light. All dilutions may be stored unprotected from light under normal light conditions up to 24 hours after preparation. Intravenous infusions should be made slowly over a period of not less than 15 minutes, 30 minutes before beginning cancer chemotherapy and repeated every 2 hours for two doses, then every 3 hours for three doses. The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combination. For less emetogenic regimens, 1 mg/kg per dose may be adequate. If extrapyramidal symptoms should occur, inject 50 mg Benadryl® (diphenhydramine hydrochloride) intramuscularly, and EPS usually will subside.

For the Prevention of Postoperative Nausea and Vomiting: Metoclopramide Injection, USP should be given intramuscularly near the end of surgery. The usual adult dose is 10 mg; however, doses of 20 mg may be used.

To Facilitate Small Bowel Intubation: If the tube has not passed the pylorus with conventional maneuvers in 10 minutes, a single dose (undiluted) may be administered slowly by the intravenous route over a 1 to 2 minute period.

The Recommended Single Dose is: Pediatric patients above 14 years of age and adults-10 mg Metoclopramide base. Pediatric patients (6 to 14 years of age)-2.5 mg to 5 mg Metoclopramide base; (under 6 years of age)-0.1 mg/kg Metoclopramide base.

To Aid in Radiological Examinations: In patients where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine, a single dose may be administered slowly by the intravenous route over a 1 to 2 minute period.

For dosage, see intubation above.

Use in Patients with Renal or Hepatic Impairment: Since Metoclopramide is excreted principally through the kidneys, in those patients whose creatinine clearance is below 40 mL/min, therapy should be initiated at approximately one-half the recommended dosage. Depending upon clinical efficacy and safety considerations, the dosage may be increased or decreased as appropriate.

See OVERDOSAGE section for information regarding dialysis.

Metoclopramide undergoes minimal hepatic metabolism, except for simple conjugation. Its safe use has been described in patients with advanced liver disease whose renal function was normal.

NOTE: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

ADMIXTURE COMPATIBILITIES

Metoclopramide Injection, USP is compatible for mixing and injection with the following dosage forms to the extent indicated below:

Physically and Chemically Compatible up to 48 hours. Cimetidine Hydrochloride (SK&F), Mannitol, USP (Hospira), Potassium Acetate, USP (Invenex), Potassium Phosphate, USP (Invenex).

Physically Compatible up to 48 hours. Ascorbic Acid, USP (Hospira), Benztropine Mesylate, USP (MS&D), Cytarabine, USP (Upjohn), Dexamethasone Sodium Phosphate, USP (Baxter, MS&D), Diphenhydramine Hydrochloride, USP (Parke-Davis), Doxorubicin Hydrochloride, USP (Adria), Heparin Sodium, USP (Baxter), Hydrocortisone Sodium Phosphate (MS&D), Lidocaine Hydrochloride, USP (Baxter), Multi-Vitamin Infusion (must be refrigerated-USV), Vitamin B Complex with Ascorbic Acid (Roche).

Physically Compatible up to 24 hours (Do not use if precipitation occurs). Clindamycin Phosphate, USP (Upjohn), Cyclophosphamide, USP (Mead-Johnson), Insulin, USP (Lilly).

Conditionally Compatible (Use within one hour after mixing or may be infused directly into the same running IV line). Ampicillin Sodium, USP (Bristol), Cisplatin (Bristol), Erythromycin Lactobionate, USP (Hospira), Methotrexate Sodium, USP (Lederle), Penicillin G Potassium, USP (Squibb), Tetracycline Hydrochloride, USP (Lederle).

Incompatible (Do Not Mix). Cephalothin Sodium, USP (Lilly), Chloramphenicol Sodium, USP (Parke-Davis), Sodium Bicarbonate, USP (Hospira).

How is Metoclopramide Supplied

PRESERVATIVE FREE.

Metoclopramide Injection, USP, 5 mg/mL Metoclopramide base (present as the monohydrochloride monohydrate) is supplied in the following:

List

Container

Concentration

Fill

Quantity

2173

Carpuject® (22-Gauge, 1¼” Needle)

5 mg/mL

2 mL

Box of 10

2173

Carpuject with Luer Lock

5 mg/mL

2 mL

Box of 10

To prevent needle-stick injuries, needles should not be recapped, purposely bent, or broken by hand.

Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]

Protect from light. Retain in carton until ready to use.

This product is light sensitive. It should be inspected before use and discarded if either color or particulate is observed.

Dilutions may be stored unprotected from light under normal light conditions up to 24 hours after preparation. Discard unused portion.

Benadryl® is a registered trademark of Warner-Lambert Company.

Cogentin® is a registered trademark of Merck & Co., Inc.

©Hospira 2005 EN-0962 Printed in USA

HOSPIRA, INC., LAKE FOREST, IL 60045 USA


Metoclopramide (Metoclopramide)
PRODUCT INFO
Product Code 0409-2173 Dosage Form INJECTION, SOLUTION
Route Of Administration INTRAMUSCULAR, INTRAVENOUS DEA Schedule
INGREDIENTS
Name (Active Moiety) Type Strength
Metoclopramide hydrochloride (Metoclopramide) Active 5 MILLIGRAM  In 1 MILLILITER
hydrochloric acid Inactive  
sodium chloride Inactive 8.5 MILLIGRAM  In 1 MILLILITER
sodium hydroxide Inactive  
Water Inactive  
IMPRINT INFORMATION
Characteristic Appearance Characteristic Appearance
Color Score
Shape Symbol
Imprint Code Coating
Size
PACKAGING
# NDC Package Description Multilevel Packaging
1 0409-2173-32 10 SYRINGE In 1 BOX contains a SYRINGE, PLASTIC
1 2 MILLILITER In 1 SYRINGE, PLASTIC This package is contained within the BOX (0409-2173-32)

Revised: 04/2006





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solution, metoclopramide ijnection usp metoclopramide oral solution, metoclopramide inejction usp metoclopramide oral solution, metoclopramide injcetion usp metoclopramide oral solution, metoclopramide injetcion usp metoclopramide oral solution, metoclopramide injeciton usp metoclopramide oral solution, metoclopramide injectoin usp metoclopramide oral solution, metoclopramide injectino usp metoclopramide oral solution, metoclopramide injectio nusp metoclopramide oral solution, metoclopramide injectionu sp metoclopramide oral solution, metoclopramide injection sup metoclopramide oral solution, metoclopramide injection ups metoclopramide oral solution, metoclopramide injection us p metoclopramide oral solution, metoclopramide injection usp metoclopramide oral solution, metoclopramide injection usp m etoclopramide oral solution, metoclopramide injection usp emtoclopramide oral solution, metoclopramide injection usp mteoclopramide oral solution, metoclopramide injection usp meotclopramide oral solution, metoclopramide injection usp metcolopramide oral solution, metoclopramide injection usp metolcopramide oral solution, metoclopramide injection usp metocolpramide oral solution, metoclopramide injection usp metoclporamide oral solution, metoclopramide injection usp metoclorpamide oral solution, metoclopramide injection usp metocloparmide oral solution, metoclopramide injection usp metocloprmaide oral solution, metoclopramide injection usp metoclopraimde oral solution, metoclopramide injection usp metoclopramdie oral solution, metoclopramide injection usp metoclopramied oral solution, metoclopramide injection usp metoclopramid eoral solution, metoclopramide injection usp metoclopramideo ral solution, metoclopramide injection usp metoclopramide roal solution, metoclopramide injection usp metoclopramide oarl solution, metoclopramide injection usp metoclopramide orla solution, metoclopramide injection usp metoclopramide ora lsolution, metoclopramide injection usp metoclopramide orals olution, metoclopramide injection usp metoclopramide oral oslution, metoclopramide injection usp metoclopramide oral sloution, metoclopramide injection usp metoclopramide oral soultion, metoclopramide injection usp metoclopramide oral soltuion, metoclopramide injection usp metoclopramide oral soluiton, metoclopramide injection usp metoclopramide oral solutoin, metoclopramide injection usp metoclopramide oral solutino, mmetoclopramide injection usp metoclopramide oral solution, meetoclopramide injection usp metoclopramide oral solution, mettoclopramide injection usp metoclopramide oral solution, metooclopramide injection usp metoclopramide oral solution, metocclopramide injection usp metoclopramide oral solution, metocllopramide injection usp metoclopramide oral solution, metocloopramide injection usp metoclopramide oral solution, metocloppramide injection usp metoclopramide oral solution, metocloprramide injection usp metoclopramide oral solution, metoclopraamide injection usp metoclopramide oral solution, metocloprammide injection usp metoclopramide oral solution, metoclopramiide injection usp metoclopramide oral solution, metoclopramidde injection usp metoclopramide oral solution, metoclopramidee injection usp metoclopramide oral solution, metoclopramide injection usp metoclopramide oral solution, metoclopramide iinjection usp metoclopramide oral solution, metoclopramide innjection usp metoclopramide oral solution, metoclopramide injjection usp metoclopramide oral solution, metoclopramide injeection usp metoclopramide oral solution, metoclopramide injecction usp metoclopramide oral solution, metoclopramide injecttion usp metoclopramide oral solution, metoclopramide injectiion usp metoclopramide oral solution, metoclopramide injectioon usp metoclopramide oral solution, metoclopramide injectionn usp metoclopramide oral solution, metoclopramide injection usp metoclopramide oral solution, metoclopramide injection uusp metoclopramide oral solution, metoclopramide injection ussp metoclopramide oral solution, metoclopramide injection uspp metoclopramide oral solution, metoclopramide injection usp metoclopramide oral solution, metoclopramide injection usp metoclopramide oral solution, metoclopramide injection usp mmetoclopramide oral solution, metoclopramide injection usp meetoclopramide oral solution, metoclopramide injection usp mettoclopramide oral solution, metoclopramide injection usp metooclopramide oral solution, metoclopramide injection usp metocclopramide oral solution, metoclopramide injection usp metocllopramide oral solution, metoclopramide injection usp metocloopramide oral solution, metoclopramide injection usp metocloppramide oral solution, metoclopramide injection usp metocloprramide oral solution, metoclopramide injection usp metoclopraamide oral solution, metoclopramide injection usp metocloprammide oral solution, metoclopramide injection usp metoclopramiide oral solution, metoclopramide injection usp metoclopramidde oral solution, metoclopramide injection usp metoclopramidee oral solution, metoclopramide injection usp metoclopramide oral solution, metoclopramide injection usp metoclopramide ooral solution, metoclopramide injection usp metoclopramide orral solution, metoclopramide injection usp metoclopramide oraal solution, metoclopramide injection usp metoclopramide orall solution, metoclopramide injection usp metoclopramide oral solution, metoclopramide injection usp metoclopramide oral ssolution, metoclopramide injection usp metoclopramide oral soolution, metoclopramide injection usp metoclopramide oral sollution, metoclopramide injection usp metoclopramide oral soluution, metoclopramide injection usp metoclopramide oral soluttion, metoclopramide injection usp metoclopramide oral solutiion, metoclopramide injection usp metoclopramide oral solutioon, metoclopramide injection usp metoclopramide oral solutionn, etc.



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