Methacholine Solution

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Methacholine Solution


Generic Name: Methacholine Inhalation Solution (meth-ah-KOH-leen)
Brand Name: Provocholine

Methacholine Solution is only used during lung function tests to determine if a patient has asthma. It is not used to treat asthma. Methacholine Solution may cause severe breathing problems in some patients. It should only be used in a setting where emergency medicines and equipment are available to treat severe breathing problems if they occur. Methacholine Solution should not be given to anyone who has apparent symptoms of asthma, wheezing, or very low lung function tests.


Methacholine Solution is used for:

Determining if you have asthma.

Methacholine Solution is a cholinergic bronchoconstrictor agent. It works by stimulating certain nerve fibers in the lung, which causes muscle spasms of the airways.

Do NOT use Methacholine Solution if:

  • you are allergic to any ingredient in Methacholine Solution or to similar medicines
  • you are taking a beta-blocker (eg, propranolol)
  • you have symptoms of asthma (eg, wheezing) or very low lung function test results

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methacholine Solution:

Some medical conditions may interact with Methacholine Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have seizures, heart disease, thyroid disease, blockage of the bladder or trouble urinating, eye problems, chronic obstructive pulmonary disease (COPD), high or low blood pressure, nerve problems (eg, vagotonia), Parkinson disease, glaucoma, intestinal or abdominal problems, or stomach ulcers

Some MEDICINES MAY INTERACT with Methacholine Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol) because the side effects of Methacholine Solution, such as difficulty breathing, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Methacholine Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methacholine Solution:

Use Methacholine Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Methacholine Solution is usually administered at your doctor"s office, hospital, or clinic.
  • Methacholine Solution is for inhalation only. It should not be injected or taken by mouth. Ask your doctor or pharmacist any questions you may have about Methacholine Solution.
  • If you miss a dose of Methacholine Solution, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Methacholine Solution.

Important safety information:

  • Women of childbearing age should receive Methacholine Solution either within 10 days after the onset of menstruation or within 2 weeks of a negative pregnancy test.
  • LAB TESTS, including lung function tests, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
  • Use Methacholine Solution with extreme caution in CHILDREN younger than 5 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if Methacholine Solution can cause harm to the fetus. If you become pregnant while taking Methacholine Solution, discuss with your doctor the benefits and risks of using Methacholine Solution during pregnancy. It is unknown if Methacholine Solution is excreted in breast milk. Do not breast-feed while using Methacholine Solution.

Possible side effects of Methacholine Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; itching; lightheadedness; throat irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; cough; fainting; severe dizziness; wheezing.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include fainting; loss of consciousness; severe chest pain with pain possibly extending down the arm.

Proper storage of Methacholine Solution:

Methacholine Solution is usually handled and stored by a health care provider. If you are using Methacholine Solution at home, store Methacholine Solution as directed by your pharmacist or health care provider. Keep Methacholine Solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Methacholine Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Methacholine Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Methacholine Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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