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|Mesalamine Suppositories

Mesalamine Suppositories

Mesalamine Suppositories is used for:

Treating various forms of mild to moderate inflammation of the colon.

Mesalamine Suppositories is a 5-aminosalicylic acid (5-ASA). It works by preventing the production of substances that cause the inflammation of the colon.

Do NOT use Mesalamine Suppositories if:

• you are allergic to any ingredient in Mesalamine Suppositories, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), or salicylates (eg, aspirin)
• you are younger than 18 years of age and you have the flu or chicken pox
• you are taking probenecid or sulfinpyrazone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mesalamine Suppositories:

Some medical conditions may interact with Mesalamine Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have had a stroke, bleeding in the brain, or an aneurysm
• if you have Kawasaki syndrome, the flu, chicken pox, or a rheumatic (inflammatory) disease (eg, osteoarthritis)

Some MEDICINES MAY INTERACT with Mesalamine Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Carbonic anhydrase inhibitors (eg, acetazolamide) because the effectiveness of Mesalamine Suppositories may be decreased
• Gingko biloba extract because side effects, such as increased bleeding, may occur
• Insulin, meglitinide antidiabetics (eg, repaglinide), sulfonylureas (eg, glipizide), or valproic acid because the actions and side effects of these medicines may be increased
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), probenecid, or sulfinpyrazone because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mesalamine Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mesalamine Suppositories:

Use Mesalamine Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• If the suppository is too soft to use, put it in the refrigerator for about 15 minutes or run cold water over it. Then remove the wrapper and moisten the suppository with cool water. Lie down on your side. Use your finger to push the pointed end of the suppository well up into the rectum.
• Do not handle the suppository too much. This will cause the suppository to melt before it can be inserted.
• Wash your hands thoroughly after using Mesalamine Suppositories.
• For best results, keep the suppository inserted for at least 1 to 3 hours.
• Continue to use Mesalamine Suppositories for the entire course of treatment.
• If you miss a dose of Mesalamine Suppositories, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Mesalamine Suppositories.

Important safety information:

• Mesalamine Suppositories may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Mesalamine Suppositories. Using Mesalamine Suppositories alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Mesalamine Suppositories may cause increased sensitivity to sunlight. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Mesalamine Suppositories. Use sunscreen or protective clothing if you must be outside for a prolonged period.
• Some of these products contain sulfites, which can cause allergic reactions in certain individuals (eg, asthma patients). If you have previously had allergic reactions to sulfites, contact your pharmacist to determine if the product you are taking contains sulfites.
• Use Mesalamine Suppositories with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Mesalamine Suppositories during pregnancy. Mesalamine Suppositories is excreted in breast milk. If you are or will be breast-feeding while using Mesalamine Suppositories, contact your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Mesalamine Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; gas; hair loss; headache; mild abdominal discomfort or pain; nausea; stomach pain.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or coffee ground-like vomit; bloody stools; chest pain; fever, chills, or sore throat; severe headache; sudden or severe stomach pain.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; dehydration; diarrhea; dizziness; drowsiness; fever; headache; quick and short breathing; ringing in the ears; sweating; vomiting.

Store Mesalamine Suppositories at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Mesalamine Suppositories out of the reach of children and away from pets.

General information:

• If you have any questions about Mesalamine Suppositories, please talk with your doctor, pharmacist, or other health care provider.
• Mesalamine Suppositories is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Mesalamine Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.