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|Mepenzolate Bromide |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Mepenzolate BromidePronouncation: (meh-PEN-zoe-late BROE-mide)Class: Quarternary anticholinergic Trade Names: Mechanism of ActionPharmacologyDiminishes gastric acid and pepsin secretion; suppresses spontaneous contractions of the colon. It is a post-ganglionic parasympathetic inhibitor. PharmacokineticsAbsorptionOral absorption is low. EliminationOver a 5-day period, 3% to 22% is excreted in the urine, with the majority appearing on day 1. The remainder appears in the feces and is presumed not to have been absorbed. Indications and UsageAdjunctive therapy in the treatment of peptic ulcer. ContraindicationsGlaucoma; obstructive uropathy (eg, bladder neck obstruction caused by prostatic hypertrophy); obstructive GI tract disease (eg, pyloric duodenal stenosis); paralytic ileus; intestinal atony of the elderly or debilitated patient; unstable CV status in acute GI hemorrhage; toxic megacolon complicating ulcerative colitis; myasthenia gravis; allergic or idiosyncratic reactions to any component of the product or related compounds. Dosage and AdministrationAdultsPO 25 or 50 mg qid, preferably with meals and at bedtime. Storage/StabilityStore at controlled room temperature (59° to 86°F). Protect from excessive heat. Drug InteractionsAgents used to treat achlorhydriaMay antagonize the effect of mepenzolate. Amantadine, antiarrhythmic agents of class I (eg, quinidine), antihistamines, antipsychotic agents (eg, phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (eg, meperidine), nitrates, nitrites, sympathomimetic agents, tricyclic antidepressants, other drugs with anticholinergic activityThese agents may increase certain actions or side effects of anticholinergic drugs. AntacidsMay interfere with mepenzolate absorption; avoid simultaneous administration. Antiglaucoma agentsAction may be antagonized by mepenzolate. DigoxinSerum digoxin levels may be increased in patients taking slow-dissolving dosage forms. Drugs that alter GI motility (eg, metoclopramide)Action may be antagonized by mepenzolate. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularTachycardia; palpitations. CNSMental confusion; dizziness; weakness; drowsiness; headache; nervousness; insomnia; psychosis (including signs and symptoms of confusion, disorientation, short-term memory loss, hallucinations, dysarthria, ataxia, coma, euphoria, decreased anxiety, fatigue, insomnia, agitation, inappropriate affect). DermatologicUrticaria. EENTIncreased ocular tension; cycloplegia; blurred vision; dilated pupil. GIVomiting; nausea; constipation; loss of taste; bloated feeling; dry mouth. GenitourinaryUrinary retention; urinary hesitancy; suppression of lactation; impotence. MiscellaneousAnaphylaxis; decreased sweating. PrecautionsPregnancyCategory B . LactationUndetermined. ChildrenSafety and efficacy not established. Special Risk PatientsUse with caution in the elderly and in patients with autonomic neuropathy, hepatic or renal disease, ulcerative colitis, coronary heart disease, CHF, cardiac arrhythmia, tachycardia, hypertension, prostatic hypertrophy, or hyperthyroidism. DiarrheaMay be symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Treatment of diarrhea with drug is inappropriate and possibly harmful. Heat prostrationCan occur in presence of high environmental temperature. OverdosageSymptomsHeadache, nausea, vomiting, blurred vision, dilated pupils, hot, dry skin, dizziness, dryness of the mouth, difficulty swallowing, CNS stimulation, curare-like action (neuromuscular blockade). Patient Information
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