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|Maprotiline HCl |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Maprotiline HClPronouncation: (ma-PRO-tih-leen HIGH-droe-KLOR-ide)Class: Tetracyclic compound Trade Names: Mechanism of ActionPharmacologyInhibits norepinephrine (but not serotonin) reuptake. PharmacokineticsAbsorptionMean T max is 12 hr. DistributionMaprotiline protein binding is 88% and apparent Vd is 13 to 24 L/kg. MetabolismMaprotiline is metabolized in the liver. EliminationMaprotiline is excreted in urine and feces. The mean t ½ is 51 hr. Indications and UsageDepression; anxiety associated with depression. Unlabeled UsesRelief of chronic neurogenic pain. ContraindicationsHypersensitivity to tricyclic antidepressants; MI acute recovery period; seizure disorder; concomitant use with MAO inhibitors. Dosage and AdministrationAdults Initial dosePO 25 to 75 mg/day as single dose or divided doses. May be increased to 150 mg/day (outpatient) or 225 mg/day (inpatient). Storage/StabilityStore at controlled room temperature. Drug InteractionsAlcohol, CNS depressantsAdditive CNS effects possible. MAO inhibitorsMay precipitate hypertensive crisis and convulsions with possibly fatal results. Discontinue at least 14 days before starting maprotiline. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularSyncope; tachycardia; palpitations; orthostatic hypotension; hypertension; MI; arrhythmias; heart block. CNSDrowsiness; dizziness; hallucinations; disorientation; mania; exacerbation of psychosis; nervousness; fatigue; headache; anxiety; tremor; insomnia; agitation; seizures. EENTBlurred vision; mydriasis. GIDry mouth; constipation; nausea; diarrhea. GenitourinaryImpotence; urinary retention. HematologicBone marrow depression, including agranulocytosis; eosinophilia; purpura; thrombocytopenia; leukopenia. HepaticIncreased bilirubin and alkaline phosphatase. MetabolicAltered blood glucose levels. MiscellaneousHypersensitivity (eg, rash, itching, photosensitivity, petechiae, edema, drug fever). PrecautionsPregnancyCategory B . LactationExcreted in breast milk. ChildrenSafety and efficacy not established. ElderlyUse lower doses. Special Risk PatientsUse with caution in patients with history of seizures, urinary retention, urethral or ureteral spasm, angle-closure glaucoma or increased IOP, CV disorders, hyperthyroid patients or those receiving thyroid medication, hepatic or renal impairment, schizophrenic or paranoid patients. Severe depressionDo not allow patient to possess more than small quantities of drug. SeizuresMay occur in therapeutic dose or overdose. OverdosageSymptomsHypotension, tachycardia, ventricular arrhythmias, CNS depression, seizures, respiratory depression, coma. Patient Information
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