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|Maprotiline

Maprotiline

Maprotiline is used for:

Relieving depression and anxiety caused by depression. It may also be used for other conditions as determined by your doctor.

Maprotiline is a tetracyclic antidepressant. It works by increasing the activity of certain chemicals in the brain (eg, norepinephrine, serotonin), which help improve mood.

Do NOT use Maprotiline if:

• you are allergic to any ingredient in Maprotiline
• you are have taken furazolidone a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days
• you are taking astemizole, terfenadine, cisapride, dofetilide, droperidol, fluoroquinolones (eg, ciprofloxacin), ketolides (eg, telithromycin) macrolides (eg, erythromycin), mibefradil, or pimozide
• you have a history of seizures or you have recently had a heart attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Maprotiline :

Some medical conditions may interact with Maprotiline . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of mental illness (eg, bipolar disorder, mania, manic-depression), or have considered or attempted suicide
• if you have alcoholism or regularly consume 3 or more alcoholic beverages per day
• if you have glaucoma, an irregular heartbeat, heart disease, chest pain, liver disease, prostate problems, an overactive thyroid, increased pressure in the eye, or muscle problems, or you are unable to urinate (urinary retention)
• if you have porphyria or you have recently had surgery

Some MEDICINES MAY INTERACT with Maprotiline . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, scopolamine), bupropion, cimetidine, azole antifungals (eg, fluconazole), MAO inhibitors (eg, phenelzine, phenothiazines (eg, chlorpromazine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of side effects from Maprotiline may be increased
• Astemizole, cisapride, dofetilide, droperidol, fluoroquinolones (eg, ciprofloxacin), ketolides (eg, telithromycin), macrolides (eg, erythromycin), mibefradil, pimozide, or terfenadine because the risk of serious side effects, such as seizures and irregular heartbeat, may be increased
• Barbiturates (eg, phenobarbital) or hydantoins (eg, phenytoin) because they may decrease the effectiveness of Maprotiline
• Carbamazepine, thyroid medicines (eg, levothyroxine), or stimulants (eg, albuterol, pseudoephedrine) because their side effects may be increased
• Warfarin because side effects such as serious bleeding may be increased
• Clonidine, guanethidine, or guanfacine because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Maprotiline may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Maprotiline :

Use Maprotiline as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Maprotiline comes with an additional patient information sheet called a Medication Guide. Read it carefully and reread it each time you get Maprotiline refilled.
• Maprotiline may be taken with food or on an empty stomach.
• Avoid eating or drinking grapefruit juice while taking Maprotiline .
• Maprotiline may take up to 30 days to control symptoms of depression. Continue to use Maprotiline even if you feel well. Do not miss any doses.
• If you miss a dose of Maprotiline , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Maprotiline .

Important safety information:

• Maprotiline may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Maprotiline . Using Maprotiline alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Maprotiline . Maprotiline will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Alcoholic beverages, hot weather, exercise, and fever can increase dizziness. To prevent dizziness or fainting, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness or weakness.
• Involuntary and uncontrollable movements may develop in patients taking Maprotiline . Occurrence is highest among the elderly, especially women. The risk of developing these involuntary movements and the likelihood they will become permanent are increased with long-term use and with high doses. However, it is possible to develop these symptoms after short-term use at low doses. Contact your health care provider at once if any of the following occur: involuntary movements of the tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs.
• Maprotiline may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Maprotiline . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• Do not become overheated in hot weather or during exercise or other activities since heatstroke may occur.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Maprotiline .
• Use caution in the ELDERLY because they may be more sensitive to its effects, especially lightheadedness upon standing; rapid heartbeat; breathing problems; difficult urination; and constipation.
• Use Maprotiline with extreme caution in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Maprotiline , discuss with your doctor the benefits and risks of using Maprotiline during pregnancy. Maprotiline is excreted in the breast milk. If you are or will be breast-feeding while you are using Maprotiline , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Maprotiline :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety or nervousness; blurred vision; constipation; dizziness; drowsiness; dry mouth; headache; nausea; tiredness; upset stomach; weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in sexual function; confusion; delusions; disorientation; fast or irregular heartbeat; fainting; fever; hallucinations; involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs; lightheadedness; ringing in the ears; seizures; severe or persistent nervousness or anxiety; sore throat; tremors; trouble sleeping; trouble urinating; unusual bleeding or bruising; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include agitation; confusion; drowsiness; dry mouth; enlarged pupils; fast or irregular heartbeat; flushing; hallucinations; loss of consciousness; seizures; stupor; trouble breathing; vomiting.

Store Maprotiline at room temperature, below 86 degrees F (30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Maprotiline out of the reach of children and away from pets.

General information:

• If you have any questions about Maprotiline , please talk with your doctor, pharmacist, or other health care provider.
• Maprotiline is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• Do not use Maprotiline for other health conditions.
• If your symptoms do not improve or if they become worse, check with your doctor.
• If your symptoms do not improve after taking Maprotiline for 4 weeks, inform your doctor.
• If using Maprotiline for an extended period of time, obtain refills before your supply runs out.

This information is a summary only. It does not contain all information about Maprotiline . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.