Macrodantin Macrocrystalline Capsules

|Macrodantin Macrocrystalline Capsules

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Macrodantin Macrocrystalline Capsules

Generic Name: Nitrofurantoin Macrocrystalline Capsules (NYE-troe-fure-AN-toin)
Brand Name: Examples include Macrobid and Macrodantin

Macrodantin Macrocrystalline Capsules is used for:

Treating and preventing urinary tract infections caused by certain bacteria.

Macrodantin Macrocrystalline Capsules is a urinary tract antibiotic. It works by interfering with various chemical processes in the bacteria, which results in the death of the bacteria.

Do NOT use Macrodantin Macrocrystalline Capsules if:

  • you are allergic to any ingredient in Macrodantin Macrocrystalline Capsules
  • you have little or no urine formation or you have kidney problems
  • you are pregnant and at term (38 to 42 weeks pregnant), when the onset of labor is about to occur, or during labor and delivery
  • the patient is younger than 1 month old

Contact your doctor or health care provider right away if any of these apply to you.

Before using Macrodantin Macrocrystalline Capsules:

Some medical conditions may interact with Macrodantin Macrocrystalline Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have anemia, blood chemical abnormalities, diabetes, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, lung disease, nerve damage, porphyria, or vitamin B deficiency
  • if you are in a weakened state

Some MEDICINES MAY INTERACT with Macrodantin Macrocrystalline Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Probenecid or sulfinpyrazone because they may decrease Macrodantin Macrocrystalline Capsules"s effectiveness
  • Hydantoins (eg, phenytoin) because their effectiveness may be decreased by Macrodantin Macrocrystalline Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Macrodantin Macrocrystalline Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Macrodantin Macrocrystalline Capsules:

Use Macrodantin Macrocrystalline Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take medicine by mouth with food, preferably breakfast and dinner, or milk to enhance tolerance and improve absorption of Macrodantin Macrocrystalline Capsules.
  • Do not take an antacid that has magnesium trisilicate in it while you take Macrodantin Macrocrystalline Capsules. Check with your pharmacist if you are unsure which antacids have magnesium trisilicate in them.
  • To clear up your infection completely, take Macrodantin Macrocrystalline Capsules for the full course of treatment. Keep taking it even if you feel better in a few days.
  • If you miss a dose of Macrodantin Macrocrystalline Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Macrodantin Macrocrystalline Capsules.

Important safety information:

  • Macrodantin Macrocrystalline Capsules may cause drowsiness, dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Macrodantin Macrocrystalline Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Macrodantin Macrocrystalline Capsules may cause severe lung damage that may be permanent or fatal. If lung damage occurs, it may be sudden or chronic and may not be immediately recognized. This usually occurs in patients who are taking the medicine for 6 months or longer. Contact your health care provider immediately if chest pain, coughing, difficulty breathing (especially upon exertion), or noticeable changes in lung function occur. Symptoms usually occur during the first 1 to 2 weeks of therapy.
  • Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Long-term or repeated use of Macrodantin Macrocrystalline Capsules may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Macrodantin Macrocrystalline Capsules only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use Macrodantin Macrocrystalline Capsules for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Macrodantin Macrocrystalline Capsules may discolor the urine. This is normal and not a cause for concern.
  • Diabetes patients - Macrodantin Macrocrystalline Capsules may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Macrodantin Macrocrystalline Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Macrodantin Macrocrystalline Capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially side effects involving the lungs and liver.
  • Macrodantin Macrocrystalline Capsules should not be used in CHILDREN younger than 1 month old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Macrodantin Macrocrystalline Capsules while you are pregnant. Do NOT use Macrodantin Macrocrystalline Capsules if you are at term (38 to 42 weeks pregnant), when the onset of labor is about to occur, or during labor and delivery. Macrodantin Macrocrystalline Capsules is found in breast milk. Do not breast-feed while taking Macrodantin Macrocrystalline Capsules.

Possible side effects of Macrodantin Macrocrystalline Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Chills; cough; dizziness; drowsiness; fever; headache; loss of appetite; nausea; rash; tingling or numbness in fingers or toes; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; bloody stools; chest pain; coughing; general body discomfort; increased pressure in the head; inflammation of the pancreas (stomach tenderness; nausea; vomiting; fever; increased pulse); tingling, numbness or burning of the fingers and toes; severe diarrhea; shortness of breath, especially when using energy; stomach pain/cramps; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include vomiting.

Proper storage of Macrodantin Macrocrystalline Capsules:

Store Macrodantin Macrocrystalline Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Keep this medicine out of the reach of children and away from pets.

General information:

  • If you have any questions about Macrodantin Macrocrystalline Capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Macrodantin Macrocrystalline Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Macrodantin Macrocrystalline Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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