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|Liotrix |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home LiotrixPronouncation: (LIE-oh-trix)Class: Thyroid hormone Trade Names: Trade Names: Trade Names: Trade Names: Trade Names: Mechanism of ActionPharmacologyIncreases metabolic rate of body tissues; is needed for normal growth and maturation. PharmacokineticsAbsorption40% to 80% of T 4 is absorbed; absorption is increased by fasting and decreased by certain foods. Approximately 95% of T 3 is absorbed in 4 hr. DistributionMore than 99% is bound to serum proteins. Minimal amounts excreted in breast milk. MetabolismApproximately 80% of T 3 comes from monodeiodination of T 4 . Conjugated hormone is found in the bile and gut where it may undergo enterahepatic circulation. EliminationPrimarily eliminated by the kidneys. Approximately 20% of T 4 is excreted in feces. Special PopulationsAgeT 4 absorption and urinary excretion are decreased with age. Indications and UsageReplacement or supplemental therapy in hypothyroidism; pituitary TSH suppression in treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto"s), multinodular goiter, and management of thyroid cancer; diagnostic agent in suppression tests to differentiate suspected and hyperthyroidism or thyroid gland autonomy. ContraindicationsDiagnosed but uncorrected adrenal cortical insufficiency; untreated thyrotoxicosis; apparent hypersensitivity to any component of the product. Dosage and AdministrationHypothyroidismAdults PO Start with low doses, with increments depending on the cardiovascular status. Usual starting dose is 1 tablet of Thyrolar ½ with increments of 1 tablet of Thyrolar ¼ q 2 to 3 wk. In patients with long-standing myxedema, the recommended starting dose is 1 tablet daily of Thyrolar ¼ and reduce dosage if angina occurs. Readjust dosage within first 4 wk of therapy after proper clinical and laboratory evaluations, including serum levels of T 4 (bound and free) and TSH. Congenital HypothyroidismChildren (over 12 yr) PO More than 18.75 mcg of T 3 and 75 mcg T 4 daily. Children (6 to 12 yr)PO 12.5 mcg of T 3 and 50 mcg T 4 to 18.75 mcg of T 3 and 75 mcg T 4 daily. Children (1 to 5 yr)PO 9.35 mcg of T 3 and 37.5 mcg of T 4 to12.5 mcg of T 3 and 50 mcg T 4 daily. Children (6 mo to 12 mo)PO 6.25 mcg of T 3 and 25 mcg of T 4 to 9.35 mcg of T 3 and 37.5 mcg of T 4 daily. Children (0 mo to 6 mo)PO 3.1 mcg of T 3 and 12.5 mcg of T 4 to 6.25 mcg of T 3 and 25 mcg of T 4 daily. Thyroid CancerAdults PO Larger amounts of thyroid hormone than those used for replacement therapy are required. Diagnostic AgentAdults PO Usual suppressive dose of T 4 is 1.56 mcg/kg/day for 7 to 10 days. General AdviceAdminister prescribed dose once daily. When given on an empty stomach, absorption is increased. However, to maintain steady blood levels and effect, be consistent in administering drug with or without food. Storage/StabilityStore tablets in refrigerator (36° to 46°F). Drug InteractionsAnticoagulantsMay increase anticoagulant effect. Cholestyramine, colestipolBind T 3 and T 4 in the intestine, impairing absorption. Estrogens, oral contraceptivesThyroid requirement may be increased in patients with nonfunctioning thyroid gland or receiving thyroid replacement therapy. Insulin, oral hypoglycemicsRequirements of these agents may be increased by liotrix. Laboratory Test InteractionsConsider changes in thyroid binding globulin concentration when interpreting thyroxine (T 4 ) and triiodothyronine (T 3 ) values; medicinal or dietary iodine interferes with all in vivo tests of radioiodine uptake, producing low uptakes that may not reflect true decrease in hormone synthesis. Adverse ReactionsMetabolicHypermetabolic state (indicative of hyperthyroidism). Precautions
PregnancyCategory A . LactationMinimal amounts excreted in breast milk. ChildrenWhen used for congenital hypothyroidism, routine determinations of serum T 4 or TSH are strongly advised in newborns. Special Risk PatientsUse with great caution in patients with cardiovascular disease, especially if integrity of coronary arteries is suspected, including patients with angina pectoris or the elderly; may aggravate intensity of symptoms in patients with diabetes mellitus or insipidus or adrenal cortical insufficiency. Myxedema comaRequires simultaneous administration of glucocorticoids. Weight reductionShould not be used for weight reduction; may produce serious or life-threatening toxicity particularly when given with sympathomimetics or anorexiants. OverdosageSymptomsHypermetabolic state. Patient Information
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