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Anaspaz, Cystospaz, Cystospaz-M, Levbid, Levsin, Levsin SL, Levsinex SR, |Levsinex SR

Levsinex SR

Generic Name: L-hyoscyamine (hye oh SYE a meen)
Brand Names: Anaspaz, Cystospaz, Cystospaz-M, Levbid, Levsin, Levsin SL, Levsinex SR

What is L-hyoscyamine?

L-hyoscyamine produces many effects in the body, including relief from spasms of the gastrointestinal tract (stomach and intestines), the bladder, and the biliary tract. This is helpful in controlling conditions such as colitis, spastic bladder, diverticulitis, infant colic, renal and biliary colic, peptic ulcer, irritable bowel syndrome, splenic flexure syndrome, and pancreatitis.

L-hyoscyamine also reduces the secretions of many organs, thereby helping to control conditions such as excessive stomach acid production, excessive secretion from the pancreas, and excessive sweating and drooling associated with diseases like Parkinson"s disease. In addition, L-hyoscyamine is used before surgery to reduce secretions of the nose, lungs, salivary glands, and stomach, and it is even used to help dry up excessive mucus production associated with diseases, colds, and infections.

L-hyoscyamine also has effects on the eyes and on the heart.

L-hyoscyamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about L-hyoscyamine?

Avoid becoming overheated in hot weather. L-hyoscyamine increases the risk of heat stroke because it causes decreased sweating.

Who should not take L-hyoscyamine?

• kidney disease;

• a blockage of your urinary tract (difficulty urinating);

• a blockage in your intestines, severe ulcerative colitis, or ulcerative colitis complicated by toxic megacolon;

• glaucoma; or

• myasthenia gravis.

Before taking this medication, tell your doctor if you have

• numbness or tingling in your hands or feet;

• liver disease;

• ulcerative colitis;

• thyroid problems;

• high blood pressure, an irregular heartbeat, or any type of heart disease;

• hiatal hernia or reflux disease;

• enlargement of the prostate; or

• asthma, chronic lung disease, or allergies.

You may not be able to take L-hyoscyamine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

How should I take L-hyoscyamine?

Take L-hyoscyamine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To ensure that you get a correct dose, measure the liquid form of L-hyoscyamine with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a L-hyoscyamine overdose include headache; nausea; vomiting; dry mouth; difficulty swallowing; blurred vision; dilated pupils; hot, dry skin; dizziness; drowsiness; confusion; anxiety; seizures; weak pulse; and an irregular heartbeat.

What should I avoid while taking L-hyoscyamine?

Avoid becoming overheated in hot weather. L-hyoscyamine increases the risk of heat stroke because it causes decreased sweating.

L-hyoscyamine side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• an irregular or fast heart rate;

• rash or flushing; or

• eye pain.

Other, less serious side effects may be more likely to occur. Continue to take L-hyoscyamine and talk to your doctor if you experience

• headache, dizziness, or lightheadedness;

• weakness or nervousness;

• blurred vision, large pupils, or sensitivity of the eyes to bright light;

• nausea, bloating, heartburn, or constipation;

• changes in taste;

• difficulty urinating;

• decreased sweating; or

• nasal congestion, stuffiness, or a dry mouth.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect L-hyoscyamine?

Many other drugs may increase the side effects of L-hyoscyamine. Before taking this medication, tell your doctor if you are taking any of the following medicines:

• amantadine (Symmetrel);

• quinidine (Quinaglute, Cardioquin, Quinora, Quinidex);

• antihistamines such as diphenhydramine (Benadryl, many others), brompheniramine (Dimetapp, Bromphen, many others), triprolidine (Actifed, others), and chlorpheniramine (Chlor-Trimeton, others), which are found in many over-the-counter and prescription cough, cold and allergy medications;

• decongestants and appetite suppressants such as phenylpropanolamine (Dexatrim, others), phenylephrine (Neo-Synephrine, others), and pseudoephedrine (Sudafed, others), which are also found in many over-the-counter and prescription products;

• phenothiazines such as chlorpromazine (Thorazine) and prochlorperazine (Compazine);
• other commonly used phenothiazines, including fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), thioridazine (Mellaril), trifluoperazine (Stelazine), and promazine (Sparine);
• tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); or
• other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil).

L-hyoscyamine may increase the level of digoxin (Lanoxin, Lanoxicaps) in your blood. Tell your doctor if you are taking digoxin so that your digoxin levels can be monitored and changes in your dosage can be made if necessary.

Drugs other than those listed here may also interact with L-hyoscyamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has more information about L-hyoscyamine written for health professionals that you may read.

What does my medication look like?

L-hyoscyamine is available with a prescription under several brand names in tablets, timed-release capsules, drops, and elixir formulations. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.