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|Levodopa/Carbidopa |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Levodopa/CarbidopaPronouncation: (LEE-voe-DOE-puh/CAR-bih-doe-puh)Class: Antiparkinson agent Trade Names: Trade Names: Trade Names: Trade Names: Trade Names: Novo-Levocarbidopa (Canada) Nu-Levocarb (Canada) Mechanism of ActionPharmacologyLevodopa is precursor of dopamine, which is deficient in parkinsonism patients. Carbidopa has no activity of its own but inhibits decarboxylation of levodopa, making it more available to the brain. Indications and UsageTreatment of symptoms of idiopathic Parkinson disease (paralysis agitans), postencephalitic parkinsonism and symptomatic parkinsonism associated with carbon monoxide and manganese poisoning. ContraindicationsNarrow-angle glaucoma; undiagnosed skin lesions or prior history of suspected melanoma; concurrent use of or within 2 wk of MAO inhibitors. Dosage and AdministrationIndividualize by careful titration. Combination tablets are available in ratios of carbidopa to levodopa of 1:4 (25 mg/100 mg) and 1:10 (10 mg/100 mg; 25 mg/250 mg). Tablets of the 2 ratios may be administered separately or combined prn to provide optimum dosage. Provide at least 70 to 100 mg/day of carbidopa to reduce side effects. Immediate-Release TabletsAdults PO Starting dose: 1 tablet of 25 mg carbidopa/100 mg levodopa tid or 10 mg carbidopa/100 mg levodopa tid to qid. Dosage may be increased by 1 tablet once daily or every other day as needed (max, 8 tablets/day). Sustained-Release Tablets (50 mg Carbidopa/200 mg Levodopa)Adults PO Starting dose: 1 tablet at intervals at least 6 hr. Adjust dosage based on response. Usual range is 2 to 8 tablets/day in divided doses 4 to 8 hr while awake. Allow at least a 3-day interval between adjustments. General Advice
Storage/StabilityStore at controlled room temperature (59° to 86°F). Protect from light. Protect orally disintegrating tablet from moisture. Drug InteractionsAntihypertensive drugsMay cause symptomatic orthostatic hypotension. Butyrophenones, isoniazid, papaverine, phenothiazines, phenytoin, and risperidoneMay reduce levodopa efficacy. Iron saltsMay reduce levodopa/carbidopa absorption, decreasing the clinical effects. MAO inhibitorsMay result in hypertensive crisis. Use is contraindicated. MetoclopramideMay increase levodopa/carbide absorption but, due to dopamine receptor antagonistic properties of metoclopramide, may also interfere with disease control. Tricyclic antidepressantsRare cases of hypertension and dyskinesia have occurred. Laboratory Test InteractionsMay cause false-positive reaction for urinary ketone bodies ( Clinitest ) and false-negative test results with glucose-oxidase methods of testing for glucosuria ( Clinistix , Tes-tape ). Pheochromocytoma has been falsely diagnosed in patients. Use caution when interpreting plasma and urine levels of catecholamines and their metabolites. Adverse ReactionsCardiovascularCardiac irregularities; palpitations; hypertension; phlebitis; orthostatic hypotension; MI; palpitation; syncope. CNSParanoid delusions; psychotic episodes; depression; suicidal ideation; dementia; convulsions; hallucinations; dizziness; choreiform; dystonic and other involuntary movements; fatigue; malaise; asthenia; agitation; bradykinetic episodes (ie, on-off phenomenon); confusion; dream abnormalities (including nightmares); headache; increased libido; insomnia; neuroleptic malignant syndrome; paresthesia. EENTDiplopia; blurred vision. GINausea; anorexia; vomiting; GI distress; epigastric pain; GI bleeding; dry mouth; duodenal ulcer; constipation; altered taste; dark saliva; diarrhea. GenitourinaryDark urine; urinary retention; urinary incontinence; priapism; UTI; urinary frequency. HematologicHemolytic and nonhemolytic anemia; thrombocytopenia; leukopenia; agranulocytosis. HepaticElevated LFT results; hepatotoxicity. HypersensitivityAngioedema; bullous lesions (including pemphigus-like reactions); Henoch-Schonlein purpura; pruritus; urticaria. Lab TestsPositive Coombs" test; decreased hemoglobin and hematocrit; abnormalities in bilirubin, BUN, and lactic dehydrogenase; elevated serum glucose; WBC, bacteria, and blood in urine. MusculoskeletalBack pain; muscle cramps; shoulder pain. RespiratoryDyspnea; upper respiratory tract infection. MiscellaneousFlushing; chest pain; increased sweating; dark sweat; rash. PrecautionsPregnancyCategory C . Safety and effects unknown. LactationUndetermined. Special Risk PatientsUse drug with caution in patients with wide-angle glaucoma; severe CV or pulmonary disease; bronchial asthma; renal, hepatic, or endocrine disease; or history of depression or suicidal tendencies. Abrupt withdrawalRapid withdrawal of antiparkinson drugs may produce symptoms of neuroleptic malignant syndrome. Dose conversionPatients previously given levodopa alone should discontinue levodopa use at least 12 hr before starting carbidopa/levodopa. Eventually substitute combination drug at dosage providing about 25% of previous levodopa dose. GI hemorrhageUpper GI hemorrhage has been reported in patients with history of peptic ulcer. MIClosely monitor cardiac function in patients with previous history of MI who have residual arrhythmias when initiating drug dosage adjustment in facility with provisions for intensive cardiac care. Neurologic/Psychiatric effectsLevodopa may cause involuntary movement and mental disturbances. Use drug with caution in patients with psychosis. Dyskinesias may occur at lower doses and sooner than with levodopa alone. Reduce dosages if necessary. OverdosageSymptomsMuscle twitching, blepharospasm, arrhythmias. Patient Information
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