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Nizoral, |ketoconazole

ketoconazole

Generic Name: ketoconazole (kee toe CAW nah zole)
Brand Names: Nizoral

What is ketoconazole?

Ketoconazole is an antifungal medication. It is like an antibiotic but is used to treat fungal infections.

Ketoconazole is used to treat yeast infections of the mouth, throat, and esophagus; fungal infections throughout the whole body; and serious fungal infections of the skin and nails.

Ketoconazole may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about ketoconazole?

In rare cases, ketoconazole has caused severe liver damage, sometimes resulting in death. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, itching, dark urine, or clay colored stools. These symptoms may be early signs of liver damage.

What should I discuss with my healthcare provider before taking ketoconazole?

• astemizole (Hismanal),

• cisapride (Propulsid), or

• triazolam (Halcion) or midazolam (Versed).

Dangerous or life-threatening events may occur if ketoconazole is taken with any of the medicines listed above.

Before taking ketoconazole, tell your doctor if you have

• liver disease; or

• achlorhydria (decreased stomach acid production) or if you take antacids, stomach acid reducers, or stomach ulcer medicines.

You may not be able to take ketoconazole, or you may require a dosage adjustment, special monitoring, or special directions for use during your treatment.

How should I take ketoconazole?

Take ketoconazole exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Ketoconazole is usually taken once a day. Follow your doctor"s instructions.

If you have a condition that decreases the amount of acid produced by the stomach, you may require a special mixture of this medication. Drink this solution through a straw far back in the mouth away from the teeth and follow each dose with a swish and swallow of water to prevent damage to the teeth.

It is important to take ketoconazole regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with ketoconazole to monitor progress and side effects.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Symptoms of a ketoconazole overdose are not well known but might include dizziness, ringing in the ears, headache, nausea, vomiting, diarrhea, and abdominal pain.

What should I avoid while taking ketoconazole?

Ketoconazole side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or

• liver damage (pale stools, yellowish skin or eyes, abdominal pain, unusual fatigue, or dark urine).

Other, less serious side effects may be more likely to occur. If you experience any of the following side effects, continue to take ketoconazole and talk to your doctor:

• nausea, vomiting, or abdominal pain;

• diarrhea;

• headache;

• dizziness;

• fatigue; or

• itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect ketoconazole?

• astemizole (Hismanal),

• cisapride (Propulsid), or

• triazolam (Halcion) or midazolam (Versed).

Dangerous or life-threatening events may occur if ketoconazole is taken with any of the medicines listed above.

Before taking ketoconazole, tell your doctor if you are taking any other medicines, especially any of the following:

• cyclosporine (Sandimmune, Neoral);

• tacrolimus ((Prograf);

• methylprednisolone (Medrol, others);

• antacids;

• cimetidine (Tagamet, Tagamet HB), nizatidine (Axid, Axid AR), famotidine (Pepcid, Pepcid AC), or ranitidine (Zantac, Zantac 75);

• omeprazole (Prilosec), lansoprazole (Prevacid), or rabeprazole (Aciphex);

• digoxin (Lanoxin, Lanoxicaps);

• warfarin (Coumadin);

• phenytoin (Dilantin, others);

• rifampin (Rifadin, Rimactane); or

• an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others.

You may not be able to take ketoconazole, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with ketoconazole or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about ketoconazole written for health professionals that you may read.

What does my medication look like?

Ketoconazole is available with a prescription generically and under the brand name Nizoral. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Nizoral 200 mg--round, white, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.