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|Itraconazole Solution

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Itraconazole Solution

Generic Name: Itraconazole Oral Solution (i-tra-KOE-na-zole)
Brand Name: Sporanox

Itraconazole Solution has been shown to cause decreased heart function. Contact your doctor immediately if you experience symptoms of congestive heart failure such as swelling of the hands, ankles, feet, or abdomen; bloating; shortness of breath; fast or irregular heartbeat; severe or persistent nausea; or confusion.

Use of Itraconazole Solution along with certain other medicines may increase your risk of serious and sometimes fatal heart problems, including irregular heartbeat. Do not take Itraconazole Solution if you are also taking cisapride, pimozide, quinidine, dofetilide, or levacetylmethadol (levomethadyl).

Itraconazole Solution is used for:

Treating fungal infections. It may also be used for other conditions as determined by your doctor.

Itraconazole Solution is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.

Do NOT use Itraconazole Solution if:

you are allergic to any ingredient in Itraconazole Solution
you are taking aldosterone blockers (eg, eplerenone), cisapride, dofetilide, ergot alkaloids (eg, ergotamine), erythromycin, H₁ antagonists (eg, astemizole, terfenadine), HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), levacetylmethadol (levomethadyl), midazolam, nevirapine, pimozide, quinazolines (eg, alfuzosin), quinidine, rifabutin, rifampin, triazolam, or 5-HT receptor agonists (eg, eletriptan)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Itraconazole Solution:

Some medical conditions may interact with Itraconazole Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of weakened immune system, low white blood cell levels, cystic fibrosis, kidney or liver disease, heart problems (eg, congestive heart failure, irregular heartbeat), lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD]), stomach problems (eg, low levels of stomach acid), nerve problems, HIV, or swelling
if you are on dialysis
if you are allergic to other azole antifungals (eg, itraconazole)

Some MEDICINES MAY INTERACT with Itraconazole Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

Carbamazepine, H₂ antagonists (eg, famotidine), nevirapine, phenobarbital, phenytoin, rifabutin, or rifampin because effectiveness of Itraconazole Solution may be decreased
Antiarrhythmics (eg, disopyramide, quinidine), cisapride, dofetilide, H₁ antagonists (eg, astemizole, terfenadine), halofantrine, HIV protease inhibitors (eg, ritonavir), HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), levacetylmethadol (levomethadyl), macrolide antibiotics (eg, erythromycin), pimozide , or quinolones (eg, ciprofloxacin) because the risk of severe heart effects may be increased
Benzodiazepines (eg, alprazolam, midazolam, triazolam), methadone, or narcotics (eg, codeine, morphine) because actions and side effects of these medicines may be increased, resulting in increased risk of sedation and breathing difficulties
Aldosterone blockers (eg, eplerenone), anticoagulants (eg, warfarin), aripiprazole, buspirone, calcium channel blockers (eg, nifedipine, verapamil), cilostazol, corticosteroids (eg, prednisone), cyclophosphamide, digoxin, ergot alkaloids (eg, ergotamine), erlotinib, gefitinib, imatinib, or immunosuppressants (eg, cyclosporine, sirolimus) because the actions and side effects of these medicines may be increased
Muscarinic receptor antagonists (eg, darifenacin), phosphodiesterase type 5 inhibitors (eg, sildenafil), quinazolines (eg, alfuzosin), sulfonylureas (eg, glipizide), trimetrexate, vinca alkaloids (eg, vincristine), or 5-HT receptor agonists (eg, eletriptan) because the actions and side effects of these medicines may be increased
Hormonal contraceptives (eg, birth control pills) because effectiveness may be decreased by Itraconazole Solution and pregnancy may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Itraconazole Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Itraconazole Solution:

Use Itraconazole Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Itraconazole Solution on an empty stomach at least 1 hour before or 2 hours after eating.
Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
If you are using Itraconazole Solution to treat a mouth or throat infection, swish Itraconazole Solution in your mouth for several seconds before swallowing, unless directed otherwise by your doctor.
Do not take antacids within 1 hour before or 2 hours after taking Itraconazole Solution.
Take Itraconazole Solution at least 2 hours before proton pump inhibitors (eg, omeprazole).
To clear up your infection completely, continue taking Itraconazole Solution for the full course of treatment even if you feel better in a few days. Do not miss any doses.
Itraconazole Solution works best if it is taken at the same time each day.
If you miss a dose of Itraconazole Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Itraconazole Solution.

Important safety information:

Itraconazole Solution may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Itraconazole Solution. Using Itraconazole Solution alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Itraconazole Solution has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Itraconazole Solution has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when Itraconazole Solution is stopped. If you notice any of the following, contact your doctor immediately: swollen or tender abdomen, yellowing of the skin or eyes.
Itraconazole Solution is effective only against fungi. It is not effective for treating viral infections (eg, the common cold).
It is important to use Itraconazole Solution for the full course of treatment. Failure to do so may decrease the effectiveness of Itraconazole Solution and may increase the risk that the fungus will no longer be sensitive to Itraconazole Solution and will not be able to be treated by this or certain other antibiotics in the future.
Long-term or repeated use of Itraconazole Solution may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
Diabetes patients - Itraconazole Solution may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
Do not switch between the capsule and oral solution forms of Itraconazole Solution without checking with your doctor. Effectiveness and side effects of these forms of Itraconazole Solution may be different even at the same dose.
Itraconazole Solution may decrease the effectiveness of your birth control pill. To prevent pregnancy, use an additional form of birth control.
LAB TESTS, including liver function tests, may be required to monitor therapy. Be sure to keep all doctor and lab appointments.
Use Itraconazole Solution with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Itraconazole Solution during pregnancy. Itraconazole Solution is excreted in breast milk. Do not breast-feed while using Itraconazole Solution.

Possible side effects of Itraconazole Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; gas; headache; nausea; stomach pain or upset; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloating; chest pain; confusion; dark urine; diarrhea; depression; fast or irregular heartbeat; fever; loss of appetite; numbness or tingling of the hands or feet; pale stools; red, swollen, blistered, or peeling skin; severe or persistent nausea; shortness of breath; sudden weight gain; swelling of the hands, ankles, or feet; swollen or tender abdomen; unusual tiredness or fatigue; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include changes in behavior; hallucinations; seizures; slowed breathing.

Proper storage of Itraconazole Solution:

Store Itraconazole Solution below 77 degrees F (25 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Itraconazole Solution out of the reach of children and away from pets.

General information:

If you have any questions about Itraconazole Solution, please talk with your doctor, pharmacist, or other health care provider.
Itraconazole Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Itraconazole Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006

Database Edition 06.4.1.002

Where can I get more information about Itraconazole Solution ? We recommend to use www.Drugs.com

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