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Inderal LA Sustained-Release Capsules

Generic Name: Propranolol Sustained-Release Capsules (pro-PRAN-oh-lol)
Brand Name: Inderal LA

If you have angina or have had heart problems, DO NOT suddenly stop taking Inderal LA Sustained-Release Capsules without first consulting with your doctor. Severe chest pain, heart attack, very fast heart rate, and irregular heart rhythm may occur. If your doctor decides you should no longer take Inderal LA Sustained-Release Capsules, the dosage should be gradually reduced according to your doctor"s instructions. You should be closely watched by your doctor and limit physical activity to a minimum, particularly if you have certain kinds of heart disease. Some medicines or medical conditions may interact with Inderal LA Sustained-Release Capsules.

Inderal LA Sustained-Release Capsules is used for:

Treating high blood pressure, preventing angina pectoris (chest pain), and managing a heart condition called hypertrophic subaortic stenosis. It may be used alone or with other medicines. It may also be used for the prevention of migraine headaches. It may also be used for other conditions as determined by your doctor.

Inderal LA Sustained-Release Capsules is a beta-adrenergic blocking agent. It works by slowing down the heart and reducing blood pressure, which helps it pump more efficiently and reduces the workload on the heart. It may also interfere with the action of adrenaline and other similar chemicals in the brain preventing migraine headaches.

Do NOT use Inderal LA Sustained-Release Capsules if:

you are allergic to any ingredient in Inderal LA Sustained-Release Capsules
you have a very slow heartbeat and heart block; had a heart attack and have very low blood pressure or uncontrolled heart failure or shock caused by heart failure
you have asthma or Raynaud phenomenon
you are a child with diabetes or heart failure
you are taking mibefradil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Inderal LA Sustained-Release Capsules:

Some medical conditions may interact with Inderal LA Sustained-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances, or are taking medicine for allergies
if you have or have ever had an adrenal gland tumor; anaphylaxis; asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), emphysema, or other lung disease; congestive heart failure; narrowing of blood vessels of the legs, arms, stomach, or kidneys; an unusually slow heartbeat; diabetes; kidney problems; low blood sugar; or an overactive thyroid
if you have Wolff-Parkinson-White syndrome
if you are having surgery

Some MEDICINES MAY INTERACT with Inderal LA Sustained-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

Antiarrhythmics (eg, amiodarone, flecainide, quinidine), antipsychotics (eg, chlorpromazine, haloperidol), bupivacaine, calcium channel blockers (eg, mibefradil, nifedipine, verapamil), cimetidine, ketanserin, mefloquine, or thioamines (eg, tapazole) because potentially life-threatening heart-related side effects may occur, including very slow heart rate; abnormal heartbeat; lightheadedness, especially upon standing; difficulty breathing, especially when lying down; loss of function in the heart and lungs; and swelling of ankles
Barbiturates (eg, phenobarbital), clonidine, phenytoin, rifampin, or thyroid hormones (eg, levothyroxine) because they may decrease Inderal LA Sustained-Release Capsules"s effectiveness
Certain stimulants (eg, adrenalin, pseudoephedrine), hydralazine, insulin, lidocaine, quinazolines (eg, doxazosin), rizatriptan, or theophylline because their actions and the risk of their side effects may be increased by Inderal LA Sustained-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Inderal LA Sustained-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Inderal LA Sustained-Release Capsules:

Use Inderal LA Sustained-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Inderal LA Sustained-Release Capsules by mouth with or without food. The effects of Inderal LA Sustained-Release Capsules may be increased if consistently taken with food.
Swallow Inderal LA Sustained-Release Capsules whole. Do not break, crush, or chew before swallowing.
If you are taking aluminum salts (eg, aluminum hydroxide) along with Inderal LA Sustained-Release Capsules, they should be spaced at least 2 hours apart.
Inderal LA Sustained-Release Capsules works best if it is taken at the same time each day.
If you miss a dose of Inderal LA Sustained-Release Capsules, take it if you remember the same day. If you do not remember until the next day, skip the missed dose. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Inderal LA Sustained-Release Capsules.

Important safety information:

Inderal LA Sustained-Release Capsules may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Inderal LA Sustained-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Inderal LA Sustained-Release Capsules may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
Check with your doctor before drinking alcohol while you are taking Inderal LA Sustained-Release Capsules.
Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
Inderal LA Sustained-Release Capsules may mask the signs of hyperthyroidism (overactive thyroid). If you have an overactive thyroid and stop taking Inderal LA Sustained-Release Capsules too suddenly, symptoms of hyperthyroidism (eg, a rapid pulse) may occur.
Patients with a history of severe allergic reactions may be more sensitive to allergens while taking Inderal LA Sustained-Release Capsules. These patients may not respond to the usual dose of epinephrine (adrenaline).
Diabetes patients - Inderal LA Sustained-Release Capsules may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine
Tell your doctor or dentist that you take Inderal LA Sustained-Release Capsules before you receive any medical or dental care, emergency care, or surgery.
Inderal LA Sustained-Release Capsules may interfere with certain lab tests, including the glaucoma screening test. Be sure your doctor and lab personnel know you are using Inderal LA Sustained-Release Capsules.
Lab tests, including blood pressure and heart function tests, may be performed while you use Inderal LA Sustained-Release Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Inderal LA Sustained-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects.
Inderal LA Sustained-Release Capsules is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Inderal LA Sustained-Release Capsules while you are pregnant. Inderal LA Sustained-Release Capsules is found in breast milk. If you are or will be breast-feeding while you use Inderal LA Sustained-Release Capsules, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Inderal LA Sustained-Release Capsules, you may experience WITHDRAWAL symptoms, including worsening chest pain along with possible heart attack.

Possible side effects of Inderal LA Sustained-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; depression; diarrhea; dizziness; drowsiness; fatigue; hallucinations; lightheadedness; nausea; sleeplessness; stomach cramps; tiredness; vision problems; vivid dreams; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms include difficulty in breathing, especially when lying down; lightheadedness, especially upon standing; pale or blue skin; seizures (convulsions); shortness of breath; swelling of ankles; unconsciousness, possibly leading to lack of heartbeat or breathing; very slow heart rate; wheezing.

Proper storage of Inderal LA Sustained-Release Capsules:

Store Inderal LA Sustained-Release Capsules at 68 to 77 degrees F (20 to 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Inderal LA Sustained-Release Capsules out of the reach of children and away from pets.

General information:

If you have any questions about Inderal LA Sustained-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
Inderal LA Sustained-Release Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Inderal LA Sustained-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006

Database Edition 06.4.1.002

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