Inderal Solution

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Inderal Solution


Generic Name: Propranolol Injection Solution (proe-PRAN-oh-lol)
Brand Name: Inderal

If you have angina or have had heart problems, DO NOT suddenly stop taking Inderal Solution without first consulting with your doctor. Severe chest pain, heart attack, very fast heart rate, and irregular heart rhythm may occur. If your doctor decides you should no longer take Inderal Solution, the dosage should be gradually reduced according to your doctor"s instructions. You should be closely watched by your doctor and limit physical activity to a minimum, particularly if you have certain kinds of heart disease. Some medicines or medical conditions may interact with Inderal Solution.


Inderal Solution is used for:

Treating high blood pressure, preventing angina pectoris (chest pain), and managing a heart condition called hypertrophic subaortic stenosis. It may be used alone or with other medicines. It may also be used for the prevention of migraine headaches. It may also be used for other conditions as determined by your doctor.

Inderal Solution is a beta-adrenergic blocking agent. It works by slowing down the heart and reducing blood pressure, which helps it pump more efficiently and reduces the workload on the heart.

Do NOT use Inderal Solution if:

  • you are allergic to any ingredient in Inderal Solution
  • you have a very slow heartbeat and heart block; had a heart attack and have very low blood pressure or uncontrolled heart failure or shock caused by heart failure
  • you have asthma or Raynaud phenomenon
  • you are a child with diabetes or heart failure
  • you are taking mibefradil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Inderal Solution:

Some medical conditions may interact with Inderal Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine (eg, medicines to treat colds or congestion), herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances, or are taking medicine for allergies
  • if you have or have ever had an adrenal gland tumor; anaphylaxis; asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), emphysema, or other lung disease; congestive heart failure; narrowing of blood vessels of the legs, arms, stomach, or kidneys; an unusually slow heartbeat; diabetes; kidney problems; low blood sugar; or an overactive thyroid
  • if you have Wolff-Parkinson-White syndrome
  • if you are having surgery

Some MEDICINES MAY INTERACT with Inderal Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, amiodarone, flecainide, quinidine), antipsychotics (eg, chlorpromazine, haloperidol), bupivacaine, calcium channel blockers (eg, mibefradil, nifedipine, verapamil), cimetidine, ketanserin, mefloquine, or thioamines (eg, tapazole) because potentially life-threatening heart-related side effects may occur, including very slow heart rate; abnormal heartbeat; lightheadedness, especially upon standing; difficulty breathing, especially when lying down; loss of function in the heart and lungs; and swelling of ankles
  • Barbiturates (eg, phenobarbital), clonidine, phenytoin, rifampin, or thyroid hormones (eg, levothyroxine) because they may decrease Inderal Solution"s effectiveness
  • Certain stimulants (eg, adrenalin, pseudoephedrine), hydralazine, insulin, lidocaine, quinazolines (eg, doxazosin), rizatriptan, or theophylline because their actions and the risk of their side effects may be increased by Inderal Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Inderal Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Inderal Solution:

Use Inderal Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Inderal Solution is usually given as an injection at your doctor"s office, hospital, or clinic. If you will be using Inderal Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Inderal Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Inderal Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Inderal Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Inderal Solution.

Important safety information:

  • Inderal Solution may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Inderal Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Inderal Solution may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Check with your doctor before drinking alcohol while you are taking Inderal Solution.
  • Inderal Solution may mask the signs of hyperthyroidism (overactive thyroid). If you have an overactive thyroid and stop taking Inderal Solution too suddenly, symptoms of hyperthyroidism (eg, a rapid pulse) may occur.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Tell your doctor or dentist that you take Inderal Solution before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Inderal Solution may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Patients with a history of severe allergic reactions may be more sensitive to allergens while taking Inderal Solution. These patients may not respond to the usual dose of epinephrine (adrenalin).
  • Inderal Solution may interfere with certain lab tests, including the glaucoma screening test. Be sure your doctor and lab personnel know you are using Inderal Solution.
  • Lab tests, including blood pressure and heart function tests, may be performed while you use Inderal Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Inderal Solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • Inderal Solution should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Inderal Solution while you are pregnant. Inderal Solution is found in breast milk. If you are or will be breast-feeding while you use Inderal Solution, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Inderal Solution, you may experience WITHDRAWAL symptoms, including worsening chest pain along with possible heart attack.

Possible side effects of Inderal Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; depression; diarrhea; dizziness; drowsiness; fatigue; hallucinations; lightheadedness; nausea; sleeplessness; stomach cramps; tiredness; vision problems; vivid dreams; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); pain, redness, or swelling at injection site.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include difficulty in breathing, especially when lying down; lightheadedness, especially upon standing; pale or blue skin; seizures (convulsions); shortness of breath; swelling of ankles; unconsciousness, possibly leading to lack of heartbeat or breathing; very slow heart rate; wheezing.

Proper storage of Inderal Solution:

Store Inderal Solution at 77 degrees F (25 degrees C). Store away from heat and light. Protect from freezing. Store in original packaging until just before use. Discard unused portion. Do not store in the bathroom. Keep Inderal Solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Inderal Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Inderal Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Inderal Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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