drug-information.ru

|Hydrocodone Bitartrate/Guaifenesin Hydrocodone Bitartrate/Homatropine Methylbromide

Hydrocodone Bitartrate/Guaifenesin

Trade Names:
Pneumotussin 2.5
- Cough Syrup 2.5 mg hydrocodone bitartrate and 200 mg guaifenesin

Trade Names:
Pneumotussin
- Tablets 2.5 mg hydrocodone bitartrate and 300 mg guaifenesin

Trade Names:
Codiclear DH
- Syrup 5 mg hydrocodone bitartrate and 100 mg guaifenesin

Trade Names:
Hycotuss Expectorant
- Syrup 5 mg hydrocodone bitartrate and 100 mg guaifenesin

Trade Names:
Hydrocodone GF
- Syrup 5 mg hydrocodone bitartrate and 100 mg guaifenesin

Trade Names:
Kwelcof
- Liquid 5 mg hydrocodone bitartrate and 100 mg guaifenesin

Trade Names:
Vitussin
- Syrup 5 mg hydrocodone bitartrate and 100 mg guaifenesin

Mechanism of Action

Pharmacology

Suppresses cough reflex; stimulates opiate receptors in the CNS and peripherally blocks pain impulse generation.

May enhance output of respiratory tract fluid by reducing adhesiveness and surface tension, enhancing removal of viscous mucus, and making nonproductive coughs more productive and less frequent.

Indications and Usage

Symptomatic relief of irritating nonproductive cough associated with upper and lower respiratory congestion.

Contraindications

Hypersensitivity to any component of product; known hypersensitivity to other opioids; patients with increased intraocular pressure; depressed ventilatory function.

Dosage and Administration

PO 1 tsp (5 mL) after meals and at bedtime, not less than 4 hr apart (max, 6 tsp in 24 hr; max single dose, 3 tsp).

PO Start with 1 tsp (max single dose, 2 tsp).

PO Start with ½ tsp (max single dose, 1 tsp).

General Advice

Measure and administer prescribed dose of syrup using dosing syringe, dosing spoon, or dosing cup.

Storage/Stability

Store syrup at controlled room temperature (59° to 86°F). Keep tightly capped.

Drug Interactions

CNS depression may be increased.

Laboratory Test Interactions

Guaifenesin may interfere with the interpretation of the test for urinary 5-hydroxyindoleacetic acid for the diagnosis of carcinoid syndrome.

Adverse Reactions

Cardiovascular

Hypertension; postural hypotension; palpitations.

CNS

Sedation; drowsiness; mental clouding; lethargy; impairment of mental performance; impairment of physical performance; anxiety; fear; dysphoria; dizziness; psychic dependence; mood change.

EENT

Blurred vision.

GI

Nausea; vomiting.

Genitourinary

Urethral spasms; spasm of vesical sphincters; urinary retention.

Respiratory

Respiratory depression.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Not recommended for children younger than 6 yr of age.

Dependence

Hydrocodone has abuse potential; may be habit forming.

Overdosage

Symptoms

Respiratory depression, extreme somnolence progressing to stupor and coma, skeletal muscle flaccidity, cold and clammy skin.

Patient Information

• Explain name, dose, action, and potential side effects of drug.
• Advise patient to take prescribed dose up to q 4 hr as needed for cough, but to not take more than 6 times/day.
• Advise caregiver to use dosing spoon or syringe when giving liquid to children.
• Advise patient to take with food or milk if GI upset occurs.
• Advise patient that if a dose is missed to take as soon as remembered unless it is nearing time for the next dose. Caution patient not to double the dose to catch up.
• Advise patient that if cough is not controlled not to increase the dose of medication but to inform health care provider.
• Advise patient to inform health care provider if any of the following occur: cough associated with fever, rash, persistent headache, or bothersome side effects.
• Caution patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined.
• Advise patient to avoid alcohol and other CNS depressants because of risk of excessive sedation.
• Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.
• Caution patient to not take any prescription or OTC medications, or dietary supplements unless advised by health care provider.