drug-information.ru |
|Guanfacine HCl |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Guanfacine HClPronouncation: (GWAHN-fay-seen HIGH-droe-KLOR-ide)Class: Antiadrenergic, centrally acting Trade Names: Mechanism of ActionPharmacologyAppears to stimulate central alpha 2 -adrenergic receptors, with decreased sympathetic outflow causing decrease in peripheral vascular resistance and reduction in heart rate. PharmacokineticsAbsorptionAbsolute bioavailability is about 80%. T max is 1 to 4 hr. DistributionProtein binding is about 70%. Mean Vd is 6.3 L/kg. EliminationT 1/ 2 is 10 to 30 hr. About 50% is excreted in the urine as unchanged, the remainder as metabolites. Special PopulationsRenal Function ImpairmentCl is reduced; plasma levels are only slightly increased. Indications and UsageTreatment of hypertension. Unlabeled UsesAmelioration of heroin withdrawal symptoms. ContraindicationsStandard considerations. Dosage and AdministrationAdultsPO 1 mg daily at bedtime; may increase gradually up to 3 mg daily. General AdviceAdminister medication at bedtime to decrease daytime sedation. Storage/StabilityStore in tightly closed container and protect from light. Drug InteractionsAlcohol, CNS depressantsIncreased CNS depression. Barbiturates, phenytoinDecreased guanfacine levels with loss of antihypertensive effect. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularChest pain; bradycardia; palpitations. CNSSomnolence; drowsiness; dizziness; headache; sleep disturbances; insomnia; confusion; depression. DermatologicDermatitis; pruritus; sweating. EENTConjunctivitis; visual disturbance; tinnitus; rhinitis; taste perversion. GIDry mouth; constipation; diarrhea; nausea; abdominal discomfort; dyspnea. GenitourinaryUrinary incontinence; testicular disorder; decreased libido; impotence. MiscellaneousParesthesia; paresis; leg cramps; hypokinesia. PrecautionsPregnancyCategory B . LactationExcreted in breast milk. ChildrenSafety and efficacy in children younger than 12 yr not established. Special Risk PatientsUse with caution in patients with severe coronary insufficiency, recent MI, cerebrovascular disease, or chronic renal or hepatic impairment. SedationOccurs in a large percentage of patients. WithdrawalDo not discontinue therapy without consulting health care provider; drug must be withdrawn gradually to avoid rapid rise in BP (rebound hypertension). OverdosageSymptomsSevere drowsiness, hypotension, bradycardia. Patient Information
Where can I get more information about Guanfacine HCl ? We recommend to use www.Drugs.com Typical mistypes for Guanfacine HCl fuanfacine hcl, vuanfacine hcl, buanfacine hcl, huanfacine hcl, yuanfacine hcl, tuanfacine hcl, gyanfacine hcl, ghanfacine hcl, gjanfacine hcl, gianfacine hcl, g8anfacine hcl, g7anfacine hcl, guznfacine hcl, gusnfacine hcl, guwnfacine hcl, guqnfacine hcl, guabfacine hcl, guamfacine hcl, guajfacine hcl, guahfacine hcl, guandacine hcl, guancacine hcl, guanvacine hcl, guangacine hcl, guantacine hcl, guanracine hcl, guanfzcine hcl, guanfscine hcl, guanfwcine hcl, guanfqcine hcl, guanfaxine hcl, guanfavine hcl, guanfafine hcl, guanfadine hcl, guanfacune hcl, guanfacjne hcl, guanfackne hcl, guanfacone hcl, guanfac9ne hcl, guanfac8ne hcl, guanfacibe hcl, guanfacime hcl, guanfacije hcl, guanfacihe hcl, guanfacinw hcl, guanfacins hcl, guanfacind hcl, guanfacinr hcl, guanfacin4 hcl, guanfacin3 hcl, guanfacine gcl, guanfacine bcl, guanfacine ncl, guanfacine jcl, guanfacine ucl, guanfacine ycl, guanfacine hxl, guanfacine hvl, guanfacine hfl, guanfacine hdl, guanfacine hck, guanfacine hcp, guanfacine hco, uanfacine hcl, ganfacine hcl, gunfacine hcl, guafacine hcl, guanacine hcl, guanfcine hcl, guanfaine hcl, guanfacne hcl, guanfacie hcl, guanfacin hcl, guanfacinehcl, guanfacine cl, guanfacine hl, guanfacine hc, uganfacine hcl, gaunfacine hcl, gunafacine hcl, guafnacine hcl, guanafcine hcl, guanfcaine hcl, guanfaicne hcl, guanfacnie hcl, guanfacien hcl, guanfacin ehcl, guanfacineh cl, guanfacine chl, guanfacine hlc, gguanfacine hcl, guuanfacine hcl, guaanfacine hcl, guannfacine hcl, guanffacine hcl, guanfaacine hcl, guanfaccine hcl, guanfaciine hcl, guanfacinne hcl, guanfacinee hcl, guanfacine hcl, guanfacine hhcl, guanfacine hccl, guanfacine hcll, etc.
|