Fluvastatin sodium

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Fluvastatin sodium

Generic name: Fluvastatin sodium
Brand names: Lescol

Why is Fluvastatin sodium prescribed?

Fluvastatin sodium reduces "bad" LDL cholesterol--and increases "good" HDL cholesterol--in the blood, and can lower your chances of developing clogged arteries and heart disease. It is also prescribed to slow the accumulation of plaque in the arteries of people who already have coronary heart disease, and may be prescribed for you when you are released from the hospital after a heart attack.

Also, if you have coronary heart disease you may be prescribed Fluvastatin sodium to reduce the risk of undergoing coronary revascularization procedures (angioplasty, bypass surgery, or stent insertion).

Your doctor will prescribe Fluvastatin sodium only if you have been unable to reduce your blood cholesterol level sufficiently with a low-fat, low-cholesterol diet alone. For people at high risk of heart disease, current guidelines call for considering drug therapy when LDL levels reach 130. For people at lower risk, the cut-off is 160. For those at little or no risk, it"s 190.

Most important fact about Fluvastatin sodium

Fluvastatin sodium is usually prescribed only if diet, exercise, and weight loss fail to bring your cholesterol levels under control. It"s important to remember that Fluvastatin sodium is a supplement--not a substitute--for those other measures. To get the full benefit of the medication, you need to stick to the diet and exercise program prescribed by your doctor. All these efforts to keep your cholesterol levels normal are important because together they may lower your risk of heart disease.

How should you take Fluvastatin sodium?

Fluvastatin sodium is available in standard capsules and extended-release tablets (Fluvastatin sodium XL).

If you are taking standard Fluvastatin sodium capsules and you"ve been prescribed a small, single dose per day, take it at bedtime. A large dosage (80 milligrams) may be divided into 2 smaller doses and taken twice a day.

Fluvastatin sodium XL tablets should be taken once a day at bedtime. The tablets should be swallowed whole, never crushed or chewed. You may take Fluvastatin sodium with or without food.

--If you miss a dose...

If you miss a dose of Fluvastatin sodium, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.

--Storage instructions...

Store at room temperature in a tightly closed container. Protect from direct light and excessive heat.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Fluvastatin sodium.

  • More common side effects may include:
    Abdominal pain, accidental injury, diarrhea, flu-like symptoms, headache, indigestion, joint diseases, muscle pain, nasal inflammation, nausea

This side effects list is not complete. If you have any questions about side effects you should consult your doctor. Report any new or continuing symptoms to your doctor right away.

Why should Fluvastatin sodium not be prescribed?

Do not take Fluvastatin sodium while pregnant or nursing. Also avoid Fluvastatin sodium if you are experiencing liver problems, or if you have ever been found to be excessively sensitive to it. A variety of conditions that raise cholesterol levels should be ruled out before you turn to Fluvastatin sodium therapy. These problems include diabetes, kidney disease, poor thyroid function, liver disease, and alcoholism.

Special warnings about Fluvastatin sodium

Because Fluvastatin sodium may damage the liver, your doctor may order a blood test to check your liver enzyme levels before you start taking Fluvastatin sodium. Blood tests will probably be done 12 weeks after you start Fluvastatin sodium therapy, whenever your dose is increased, and periodically after that. If your liver enzymes rise too high, your doctor may tell you to stop taking Fluvastatin sodium. Your doctor will monitor you especially closely if you have ever had liver disease or if you are, or have ever been, a heavy drinker.

Since Fluvastatin sodium may cause damage to muscle tissue, be sure to tell your doctor of any unexplained muscle pain, tenderness, or weakness right away, especially if you also have a fever or feel sick. Your doctor may want to do a blood test to check for signs of muscle damage. If your blood test shows signs of muscle damage, your doctor may suggest discontinuing Fluvastatin sodium.

If your risk of muscle and/or kidney damage suddenly increases because of major surgery or injury, or conditions such as low blood pressure, severe infection, or seizures, your doctor may tell you to stop taking Fluvastatin sodium for a while.

Possible food and drug interactions when taking Fluvastatin sodium

If you take Fluvastatin sodium with certain drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Fluvastatin sodium with the following:

Cholestyramine (Questran)
Cimetidine (Tagamet)
Clofibrate (Atromid-S)
Cyclosporine (Sandimmune, Neoral)
Diclofenac (Voltaren)
Digoxin (Lanoxin, Lanoxicaps)
Erythromycin (E-Mycin, E.E.S.)
Gemfibrozil (Lopid)
Glyburide (Micronase)
Niacin (Niaspan)
Omeprazole (Prilosec)
Phenytoin (Dilantin)
Ranitidine (Zantac)
Rifampin (Rifadin)

Special information if you are pregnant or breastfeeding

You must not become pregnant while taking Fluvastatin sodium. This medication lowers cholesterol, and cholesterol is needed for a baby to develop properly. Because of the possible risk of birth defects, your doctor will prescribe Fluvastatin sodium only if you are highly unlikely to get pregnant while taking Fluvastatin sodium. If you do become pregnant while taking Fluvastatin sodium, stop taking the drug and notify your doctor right away.

Fluvastatin sodium does appear in breast milk. Therefore, Fluvastatin sodium could cause severe side effects in a nursing baby. Do not take Fluvastatin sodium while breastfeeding your baby.

Recommended dosage

Your doctor will put you on a cholesterol-lowering diet before starting treatment with Fluvastatin sodium. You should continue on this diet while you are taking Fluvastatin sodium.

ADULTS

Fluvastatin sodium Capsules

The usual starting dose is 20 to 40 milligrams per day, taken as a single dose at bedtime. The usual range after that is 20 to 80 milligrams per day. At the 80-milligram level, the dosage will be split into two 40-milligram doses taken 2 times a day. If you have kidney disease, doses over 40 milligrams should be used with caution. After 4 weeks of therapy with Fluvastatin sodium, your doctor will check your cholesterol level and adjust your dosage if necessary.

Fluvastatin sodium XL Tablets

The usual starting dose is one 80-milligram XL tablet taken as a single dose at bedtime. After 4 months of therapy with Fluvastatin sodium XL, your doctor will check your cholesterol level and adjust your dosage if necessary.

Combined Drug Therapy

If you are taking Fluvastatin sodium capsules with another cholesterol medication such as Questran, make sure you take the other drug at least 2 hours before your dose of Fluvastatin sodium.

CHILDREN

Do not give Fluvastatin sodium to children under 18 years of age.

Overdosage

Excessive doses of Fluvastatin sodium can cause a variety of stomach and intestinal problems. If you suspect an overdose, seek medical treatment immediately.





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