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|Fluoxymesterone |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home FluoxymesteronePronouncation: (flew-ox-ee-MESS-teh-rone)Class: Androgen Trade Names: Mechanism of ActionPharmacologyPromotes growth and development of male reproductive organs, maintains secondary sex characteristics, increases protein anabolism, and decreases protein catabolism. Indications and UsageReplacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone; delayed puberty (men); palliation of androgen-responsive recurrent mammary cancer in women who are more than 1 yr but less than 5 yr postmenopausal (women). ContraindicationsMen with carcinoma of the breast; men with known or suspected carcinoma of the prostate gland; women known or suspected to be pregnant; patients with serious cardiac, hepatic, or renal disease; hypersensitivity to any component of the product. Dosage and AdministrationDelayed Puberty (Men)Adults PO Titrate dose utilizing a low dose, appropriate skeletal monitoring, and by limiting the duration of therapy to 4 to 6 mo. Inoperable Carcinoma of the Breast (Women)Adults PO 10 to 40 mg/day, in divided doses, for palliative therapy. Male HypogonadismAdults PO 5 to 20 mg/day for complete replacement. General Advice
Storage/StabilityStore tablets at controlled room temperature (68° to 77°F). Drug InteractionsInsulinBlood glucose levels may be reduced by fluoxymesterone, decreasing insulin requirements. Oral anticoagulants (eg, warfarin)Effects of oral anticoagulant may be increased. Dosage reduction may be required. Laboratory Test InteractionsThyroxine-binding globulin levels may be decreased; however, thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. Adverse ReactionsCNSIncreased or decreased libido; headache; anxiety; depression; generalized paresthesia. DermatologicHirsutism; male pattern baldness; seborrhea; acne. GINausea. GenitourinaryAmenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, virilization including deepening of voice, clitoral enlargement (women); gynecomastia, excessive frequency and duration of penile erection, oligospermia (men). HematologicSuppression of clotting factors II, V, VII, and X; polycythemia. HepaticCholestatic jaundice; altered LFTs; hepatocellular neoplasms, peliosis hepatitis. MetabolicSodium, chloride, water, potassium, calcium, and inorganic phosphate retention. MiscellaneousAllergic hypersensitivity (including skin manifestations and anaphylactoid reactions). Precautions
PregnancyCategory X . Ensure that X-ray examinations of bone age are made q 6 mo during treatment of prepubertal male. LactationUndetermined. ChildrenUse with caution and only by specialists aware of the adverse effects on bone maturation. ElderlyElderly men may be at increased risk of developing prostatic hypertrophy or carcinoma. Athletic performanceAbuse of this agent to enhance athletic performance has potential risk of serious side effects. Breast cancer and immobilized patientsMay cause hypercalcemia. Delayed pubertyBecause bone maturation without compensatory linear growth can occur, use with caution in males with delayed puberty. EdemaUse with caution in patients with conditions that might be affected by fluid retention (eg, renal, hepatic, or cardiac disease). GynecomastiaMay occur and persist in patients being treated for hypogonadism. Hepatic effectsCholestatic hepatitis and jaundice may occur. Prolonged use of high doses may result in hepatic adenomas, hepatocellular carcinoma, and peliosis hepatitis. Oligospermia and reduced ejaculatory volumeMay occur after prolonged use or excessive dosage. PriapismMay be indicative of excessive dosage. Urethral obstructionMay develop in patients with benign prostatic hypertrophy. VirilizationMay occur in women using high-dose androgens. Patient Information
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