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|Fenoprofen Calcium |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Fenoprofen CalciumPronouncation: (FEN-oh-PROE-fen KAL-si-um)Class: NSAID Trade Names: Trade Names: Mechanism of ActionPharmacologyDecreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis. PharmacokineticsAbsorptionT max is 2 hr; C max is 50 mcg/mL. DistributionFenoprofen is about 99% protein bound. MetabolismMajor urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide. EliminationThe t ½ is 3 hr; about 90% is renally eliminated. Indications and UsageSymptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Unlabeled UsesSelected NSAIDs have been used in the treatment of juvenile rheumatoid arthritis, symptomatic treatment of sunburn, and for various migraine headaches. ContraindicationsHistory of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of peri-operative pain in the setting of coronary artery bypass graft surgery. Dosage and AdministrationRheumatoid Arthritis/OsteoarthritisPO 300 to 600 mg tid to qid; do not exceed 3.2 g/day. Mild/Moderate PainPO 200 mg q 4 to 6 hr prn. General Advice
Storage/StabilityStore tablets and capsules at controlled room temperature (68° to 77°F). Drug InteractionsAminoglycosides (eg, gentamicin)Plasma aminoglycoside levels may be elevated. Angiotensin-converting enzyme (ACE) inhibitorsAntihypertensive effect of ACE inhibitors may be diminished. AnticoagulantsCoadministration may prolong PT. AspirinFenoprofen Cl may be increased; coadministration is not recommended. DiureticsPatients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides. Hydantoins, sulfonamides, sulfonylureasFenoprofen may displace these drugs from their binding site. LithiumRenal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity. MethotrexateMay increase methotrexate levels. PhenobarbitalMay decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn. SSRIs (eg, fluoxetine)The risk of GI effects may be increased. Laboratory Test InteractionsFalse elevation in free and total serum T 3 as measured by Amerlex-M kit. Adverse ReactionsCardiovascularPalpitations (3%). CNSHeadache, somnolence (9%); dizziness (7%); nervousness (6%); asthenia (5%); fatigue, tremor (2%); confusion (1%). DermatologicIncreased sweating (5%); pruritus, rash (4%). EENTTinnitus (5%); blurred vision, decreased hearing (2%); nasopharyngitis (1%). GIDyspepsia (10%); nausea (8%); constipation (7%); vomiting (3%); abdominal pain, diarrhea (2%). RespiratoryDyspnea (3%); upper respiratory tract infection (2%). MiscellaneousPeripheral edema (5%). Precautions
PregnancyCategory C . Avoid in late pregnancy. LactationUndetermined. ChildrenSafety and efficacy not established. ElderlyUse with caution. HypersensitivityDo not use in aspirin-sensitive individuals because of possible cross-sensitivity. Renal FunctionAcute renal insufficiency, interstitial nephritis, hyperkalemia, hyponatremia, and renal papillary necrosis may occur. Contraindicated in patients with a history of significantly impaired renal function Hepatic FunctionUse with caution. Discontinue if any significant liver abnormalities occur. Anaphylactoid reactionsDo not administer to patients with aspirin triad, which typically occurs in patients with asthma who experience rhinitis with or with nasal polyps, or who exhibit severe, potentially fatal, bronchospasm after taking aspirin or other NSAIDs. AsthmaPatients with asthma may have aspirin-sensitive asthma, which may be associated with severe and sometimes fatal bronchospasm. Fenoprofen should not be administered to patients with this type of aspirin-sensitivity because of possible cross-reactivity. BleedingMay decrease platelet aggregation. HypertensionNew hypertension or worsening of preexisting hypertension, either of which may contribute to increased risk of CV events, may occur. Peripheral edemaHas been observed. Use with caution in patients with hypertension or compromised cardiac function. Skin reactionsSerious and sometimes fatal skin adverse reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, may occur. OverdosageSymptomsAbdominal pain, acute renal failure, ataxia, confusion, dizziness, drowsiness, dyspepsia, headache, hyperpyrexia, hypotension, metabolic acidosis, nausea, respiratory depression, tachycardia, tinnitus, tremor, vomiting. Patient Information
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