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|Erythromycin Topical

ERYTHROMYCIN (Topical)

Some commonly used brand names are:

In the U.S.—

• Akne-Mycin
• A/T/S
• Emgel
• Erycette
• EryDerm
• Erygel
• Erymax
• Ery-Sol
• Erythra-Derm
• ETS
• Staticin
• Theramycin Z
• T-Stat

In Canada—

• Sans-Acne
• Staticin

Generic name product may be available in the U.S.

Category

• Antiacne agent, topical
• Antibacterial, topical

Description

Erythromycin (eh-rith-roe-MYE-sin) belongs to the family of medicines called antibiotics. Erythromycin topical preparations are used on the skin to help control acne. They may be used alone or with one or more other medicines that are applied to the skin or taken by mouth for acne. They may also be used for other problems, such as skin infections, as determined by your doctor.

Erythromycin is available only with your doctor"s prescription, in the following dosage forms:

• Topical
• Gel (U.S.)
• Ointment (U.S.)
• Pledgets (U.S.)
• Solution (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For topical erythromycin, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to this or any of the other erythromycins. Also tell your health care professional if you are allergic to any other substances, such as preservatives or dyes.

Pregnancy—Topical erythromycin has not been studied in pregnant women. However, this medication has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding—It is not known whether topical erythromycin passes into the breast milk. Erythromycin, given by mouth or by injection, does pass into the breast milk. However, erythromycin topical preparations have not been reported to cause problems in nursing babies.

Children—Erythromycin topical solution has been tested in children 12 years of age and older and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of topical erythromycin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) medicine that is to be applied to the same area of the skin.

Proper Use of This Medicine

Before applying this medicine, thoroughly wash the affected area with warm water and soap, rinse well, and pat dry. After washing or shaving, it is best to wait 30 minutes before applying the pledget (swab), topical gel, or topical liquid form. The alcohol in them may irritate freshly washed or shaved skin.

For patients using the pledget (swab), topical gel, or topical liquid form of erythromycin:

• These forms contain alcohol and are flammable. Do not use near heat, near open flame, or while smoking .
• It is important that you do not use this medicine more often than your doctor ordered. It may cause your skin to become too dry or irritated.
• Also, you should avoid washing the acne-affected areas too often. This may dry your skin and make your acne worse. Washing with a mild, bland soap 2 or 3 times a day should be enough, unless you have oily skin. If you have any questions about this, check with your doctor.
• To use:
  • The topical liquid form of this medicine may come in a bottle with an applicator tip, which may be used to apply the medicine directly to the skin. Use the applicator with a dabbing motion instead of a rolling motion (not like a roll-on deodorant, for example). If the medicine does not come in an applicator bottle, you may moisten a pad with the medicine and then rub the pad over the whole affected area. Or you may also apply this medicine with your fingertips. Be sure to wash the medicine off your hands afterward.
  • Apply a thin film of medicine, using enough to cover the affected area lightly. You should apply the medicine to the whole area usually affected by acne, not just to the pimples themselves . This will help keep new pimples from breaking out.
  • The pledget (swab) form should be rubbed over the whole affected area. You may use extra pledgets (swabs), if needed, to cover larger areas.
  • Since these medicines contain alcohol, they may sting or burn. Therefore, do not get these medicines in the eyes, nose, mouth, or on other mucous membranes . Spread the medicine away from these areas when applying. If these medicines do get in the eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

This medicine will not cure your acne. However, to help keep your acne under control, keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a few days. You may have to continue using this medicine every day for months or even longer in some cases. If you stop using this medicine too soon, your symptoms may return. It is important that you do not miss any doses .

Dosing—The dose of topical erythromycin will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of topical erythromycin. If your dose is different, do not change it unless your doctor tells you to do so.

• For acne:
  • For gel dosage form:
    • Adults—Apply to the affected area(s) of the skin two times a day, morning and evening.
    • Children—Dose must be determined by your doctor.
  • For ointment dosage form:
    • Adults, teenagers, and children—Apply to the affected area(s) of the skin two times a day, morning and evening.
  • For pledgets dosage form:
    • Adults, teenagers, and children—Apply to the affected area(s) of the skin two times a day.
  • For topical solution dosage form:
    • Adults, teenagers, and children 12 years of age and over—Apply to the affected area(s) of the skin two times a day, morning and evening.
    • Children up to 12 years of age—Dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Keep the medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

If your acne does not improve within 3 to 4 weeks, or if it becomes worse, check with your health care professional. However, treatment of acne may take up to 8 to 12 weeks before you see full improvement.

For patients using the pledget (swab), topical gel, or topical liquid form of erythromycin:

• If your doctor has ordered another medicine to be applied to the skin along with this medicine, it is best to wait at least 1 hour before you apply the second medicine. This may help keep your skin from becoming too irritated. Also, if the medicines are used too close together, they may not work properly.
• After application of this medicine to the skin, mild stinging or burning may be expected and may last up to a few minutes or more.
• This medicine may also cause the skin to become unusually dry, even with normal use. If this occurs, check with your doctor.
• You may continue to use cosmetics (make-up) while you are using this medicine for acne. However, it is best to use only ``water-base"" cosmetics. Also, it is best not to use cosmetics too heavily or too often. They may make your acne worse. If you have any questions about this, check with your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. The following side effects may go away during treatment as your body adjusts to the medicine.

However, check with your doctor if any of the following side effects continue or are bothersome:

For erythromycin ointment

For erythromycin pledget (swab), topical gel, or topical liquid form

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 09/18/2000
Interim revision:

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