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Integrilin, |eptifibatide Eptifibatide

eptifibatide

Generic Name: eptifibatide (ep ti FYE ba tide)
Brand Names: Integrilin

What is eptifibatide?

Eptifibatide keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Eptifibatide is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries).

Eptifibatide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about eptifibatide?

Do not receive this medication if you have a stomach ulcer or ulcerative colitis, severe liver disease, severe high blood pressure, a bleeding or blood clotting disorder, a history of head injury, brain tumor, or blood clot in the brain (aneurysm), a stroke or any type of bleeding within the past 30 days, or any type of surgery, injury, or medical emergency within the past 6 weeks.

Tell your doctor if you are pregnant or plan to become pregnant during treatment with eptifibatide and aspirin.

Because eptifibatide keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

What should I discuss with my health care provider before receiving eptifibatide?

• kidney disease (or if you are on dialysis);

• a severe form of hypertension (high blood pressure);

• a bleeding or blood clotting disorder, such as hemophilia or thrombocytopenia;

• a history of blood clot in the brain (aneurysm);

• if you have had a stroke or any type of bleeding within the past 30 days; or

• if you have had any type of surgery, injury, or medical emergency within the past 6 weeks.

Before using eptifibatide, tell your doctor if you are allergic to any drugs

How is eptifibatide given?

Eptifibatide is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

If you are receiving this injection during an angioplasty procedure, the medicine will be given throughout the entire procedure and for up to 24 hours after the procedure.

Eptifibatide is usually given continuously for up to 4 days.

Eptifibatide is sometimes given together with aspirin.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Because eptifibatide keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

What happens if I miss a dose?

Since eptifibatide is usually given in a hospital or clinic setting as needed, it is not likely that you will miss a dose.

What happens if I overdose?

Symptoms of an eptifibatide overdose may include severe bleeding.

What should I avoid while receiving eptifibatide?

Eptifibatide lowers blood cells that help your blood clot. This can make it easier for you to bruise or bleed from an injury or minor cut. Avoid activities that increase your risk of a bruising or bleeding injury. Use extra caution to avoid cuts when brushing your teeth or shaving.

Eptifibatide side effects

• nosebleed or other bleeding that will not stop;

• black, bloody, or tarry stools;

• coughing up blood or vomit that looks like coffee grounds;

• feeling light-headed, fainting;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• fever, chills, body aches, flu symptoms; or

• pale skin, easy bruising or bleeding, weakness, fever, and urinating more or less than usual.

Less serious side effects may also occur, such as:

• nausea, stomach pain;

• runny or stuffy nose, cough, sore throat; or

• mild headache or dizziness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect eptifibatide?

Before receiving eptifibatide, tell your doctor if you are using any of the following drugs:

• a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); or

• any other medications used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), sulfinpyrazone (Anturane), ticlopidine (Ticlid), or urokinase (Abbokinase).

If you are using any of these drugs, you may not be able to receive eptifibatide, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect eptifibatide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about eptifibatide written for health professionals that you may read.

What does my medication look like?

Eptifibatide is available with a prescription under the brand name Integrilin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.