Enoxaparin

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|Enoxaparin

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Enoxaparin


Generic Name: Enoxaparin (eh-NOX-uh-par-in)
Brand Name: Lovenox

Enoxaparin should be used with extreme caution in patients with a history of low blood platelets due to the use of heparin. Talk with your doctor about the bleeding risks associated with Enoxaparin .

Tell your doctor you are using Enoxaparin before undergoing any procedure involving a spinal puncture or spinal anesthesia. An epidural or spinal hematoma (a blood clot on or near the spinal cord) may develop if you have a spinal puncture or spinal anesthesia while using Enoxaparin . This could result in paralysis, which could be permanent. This risk is greater if you are taking other "blood thinning" medicines (eg, aspirin, clopidogrel, warfarin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), or when certain medicine delivery devices (eg, an indwelling epidural catheter) are used.


Enoxaparin is used for:

Preventing blood clots in patients with certain acute illnesses and patients undergoing hip replacement, knee replacement, or stomach surgery. It is also used to prevent heart attack and unstable angina (chest pain). It is used with other medicines to treat blood clots.

Enoxaparin is a low molecular weight antithrombotic. It acts by inhibiting the reactions that lead to clotting of blood.

Do NOT use Enoxaparin if:

  • you are allergic to any ingredient in Enoxaparin
  • you are allergic to heparin or pork products
  • you have episodes of severe bleeding
  • you have severe or uncontrolled high blood pressure
  • you are taking salicylates (eg, aspirin) or NSAIDs (eg, ibuprofen, naproxen)
  • you have a low white blood cell count and the presence of antiplatelet antibodies

Contact your doctor or health care provider right away if any of these apply to you.

Before using Enoxaparin :

Some medical conditions may interact with Enoxaparin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines or other substances
  • if you have blood platelet problems, bleeding problems, a blood disease, heart problems, stomach problems, liver or kidney problems, low body weight, vision problems caused by diabetes, or had recent surgery (especially brain, spinal, or eye surgery)
  • if you have a history of low white blood cell counts after taking heparin
  • if you have recently given birth

Some MEDICINES MAY INTERACT with Enoxaparin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nitrates (eg, nitroglycerin, isosorbide dinitrate) or streptokinase because the effectiveness of Enoxaparin may be decreased
  • Activated protein C, cephalosporins (eg, cephalexin),NSAIDs (eg, ibuprofen, naproxen), penicillins, orsalicylates (eg, aspirin) because side effects, such as increased bleeding, may occur
  • Activated protein C or sulfonylureas (eg, glipizide) because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Enoxaparin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Enoxaparin :

Use Enoxaparin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

  • Enoxaparin is usually administered as an injection at your doctor"s office, hospital, or clinic.
  • Enoxaparin is not be injected into a muscle.
  • If you are using Enoxaparin at home, carefully follow the injection procedures taught to you by your health care provider. If the medicine contains particles, is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • If you miss a dose of Enoxaparin , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do NOT use 2 doses at once.

Ask your health care provider any questions you may have about how to use Enoxaparin .

Important safety information:

  • Enoxaparin may reduce the number of blood cells that are needed for clotting. To prevent bleeding, avoid situations where bruising or injury may occur.
  • Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell your doctor or dentist that you are using Enoxaparin .
  • LAB TESTS, including liver function, blood counts, and blood clotting time, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Enoxaparin with caution in the ELDERLY because they may be more sensitive to its effects, especially bleeding.
  • Enoxaparin is not recommended for use in CHILDREN younger than 1 month of age. Safety and effectiveness in this age group have not been established.
  • PREGNANCY and BREAST-FEEDING: If you are or plan on becoming pregnant, discuss with your doctor the benefits and risks of using Enoxaparin during pregnancy. It is unknown if Enoxaparin is excreted in breast milk. If you are or will be breast-feeding, check with your doctor to discuss the benefits and risks to your baby.

Possible side effects of Enoxaparin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Confusion; diarrhea; mild pain; nausea; pain, swelling, redness, bleeding, or bruising at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, or tarry stools; chills; difficulty urinating; difficulty walking; fever; leg weakness; numbness; pink or red urine; swelling; tingling; unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include bruising; excessive bleeding.

Proper storage of Enoxaparin :

Store at room temperature (59 to 77 degrees F) away from heat and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Enoxaparin , as well as syringes and needles, out of the reach of children and away from pets.

General information:

  • If you have any questions about Enoxaparin , please talk with your doctor, pharmacist, or other health care provider.
  • Enoxaparin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Enoxaparin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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