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|Eldepryl

Eldepryl

Eldepryl is used for:

Treating Parkinson disease. Eldepryl is taken with levodopa/carbidopa.

Eldepryl is a monoamine oxidase (MAO) inhibitor. It works by prolonging the anti-Parkinson activity of levodopa, which may help to slow the progression of Parkinson disease. Selegiline has no anti-Parkinson effects of its own and must always be given in combination with levodopa/carbidopa.

Do NOT use Eldepryl if:

• you are allergic to any ingredient in Eldepryl
• you have schizophrenia
• you are taking an anorexiant (eg, phentermine), apraclonidine, brimonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, dextromethorphan, entacapone, an herbal product (eg, ma huang), indoramin, meperidine, nefazodone, a norepinephrine reuptake inhibitor (eg, atomoxetine), papaverine, a serotonin norepinephrine reuptake inhibitor (eg, venlafaxine), sibutramine, a selective serotonin reuptake inhibitor (SSRI) antidepressant (eg, fluoxetine, citalopram), a sympathomimetic (eg, ephedrine, methylphenidate), a tetracyclic antidepressant (eg, trazodone), tolcapone, tramadol, a tricyclic antidepressant (eg, amitriptyline, doxepin), or a "triptan" (eg, sumatriptan, zolmitriptan)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Eldepryl :

Some medical conditions may interact with Eldepryl . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a mental disorder (eg, psychosis), tardive dyskinesia (twitching of the face and tongue, involuntary movements of the arms and legs), or an ulcer

Some MEDICINES MAY INTERACT with Eldepryl . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Apraclonidine or ethanol because the actions and side effects of Eldepryl may be increased
• Anorexiants (eg, phentermine), bupropion, carbamazepine, cyclobenzaprine, dextromethorphan, insulin, levodopa, meglitinide antidiabetics (eg, repaglinide), meperidine, nefazodone, norepinephrine reuptake inhibitors (eg, atomoxetine), propoxyphene, serotonin norepinephrine reuptake inhibitors (eg, venlafaxine), SSRI antidepressants (eg, fluoxetine), sibutramine, sulfonylureas (eg, glyburide), sumatriptan, sympathomimetics (eg, ephedrine, methylphenidate), tetracyclic antidepressants (eg, trazodone), tramadol, tricyclic antidepressants (eg, amitriptyline), or tryptophan because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Eldepryl may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Eldepryl :

Use Eldepryl as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Eldepryl with food.
• Most people who take Eldepryl can eat a normal diet. However, if your dosage is more than 10 mg/day, serious increases in blood pressure may occur when you eat or drink some foods and drinks. Foods or drinks that may cause a reaction include aged cheeses, sour cream, red wines, beer, bologna, pepperoni, salami, summer sausage, pickled herring, liver, meat prepared with tenderizers, canned figs, raisins, bananas, avocados, soy sauce, fava beans, or yeast extracts. Obtain a complete list of foods and drinks from your doctor or pharmacist.
• Continue to use Eldepryl even if you feel well. Do not miss any doses.
• If you miss a dose of Eldepryl , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Eldepryl .

Important safety information:

• Eldepryl may cause dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Eldepryl . Using Eldepryl alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Eldepryl may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
• Do not become overheated in hot weather or during exercise or other activities; heatstroke may occur.
• Immediately report any severe headache or unusual symptoms to your health care provider.
• Before you begin taking any new prescription or over-the-counter medicine, check with your doctor or pharmacist. This includes medicines that contain pseudoephedrine, phenylpropanolamine, or dextromethorphan.
• Follow all of these precautions for at least 4 weeks after taking the last dose of Eldepryl .
• Use Eldepryl with caution in the ELDERLY because they may be more sensitive to its effects.
• Use Eldepryl with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Eldepryl during pregnancy. It is unknown if Eldepryl is excreted in breast milk. Do not breast-feed while taking Eldepryl .

Possible side effects of Eldepryl :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; dry mouth; hallucinations; headache; lightheadedness; stomach pain; vivid dreams.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior or mood changes; chest pain; confusion; fainting; heart palpitations or changes in heart rate; nausea; severe headache; unusual body movements or difficulty moving; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms of overdose may be absent for up to 12 hours and may include confusion; dizziness; drowsiness; excitement; fast heartbeat; flushing; headache; irritability; restlessness; seizures; sweating; weakness.

Store Eldepryl at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Eldepryl out of the reach of children and away from pets.

General information:

• If you have any questions about Eldepryl , please talk with your doctor, pharmacist, or other health care provider.
• Eldepryl is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Eldepryl . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.