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Alka-Seltzer Plus Cold and Cough, Atuss DM, Atuss DR, Cerose DM, Coldtuss-DR, Corfen-DM, De-Chlor DM, De-Chlor DR, Dex PC, Ed A-Hist DM, Liquituss R-DM, Mintuss DR, Norel DM, P Chlor DM, Poly-Tussin DM, Rondec-DM, Tri-Vent DPC, Trital DM, Tussar DM, Uni-Tuss DM, |Ed A-Hist DM

Ed A-Hist DM

Generic Name: chlorpheniramine, dextromethorphan, and phenylephrine (klor feh NEER a meen, dex troe meh THOR fan, and feh nill EH frin)
Brand Names: Alka-Seltzer Plus Cold and Cough, Atuss DM, Atuss DR, Cerose DM, Coldtuss-DR, Corfen-DM, De-Chlor DM, De-Chlor DR, Dex PC, Ed A-Hist DM, Liquituss R-DM, Mintuss DR, Norel DM, P Chlor DM, Poly-Tussin DM, Rondec-DM, Tri-Vent DPC, Trital DM, Tussar DM, Uni-Tuss DM

What is chlorpheniramine, dextromethorphan, and phenylephrine?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlorpheniramine, dextromethorphan, and phenylephrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlorpheniramine, dextromethorphan, and phenylephrine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about chlorpheniramine, dextromethorphan, and phenylephrine?

What should I discuss with my healthcare provider before taking chlorpheniramine, dextromethorphan, and phenylephrine?

Before taking this medication, tell your doctor if you are allergic to chlorpheniramine, dextromethorphan, or phenylephrine, or if you have:

• kidney disease;
• liver disease;

• diabetes;

• glaucoma;

• heart disease or high blood pressure;

• diabetes;

• a thyroid disorder;

• a stomach ulcer or a stomach obstruction,

• emphysema or chronic bronchitis; or

• an enlarged prostate or urination problems.

If you have any of these conditions, you may not be able to use chlorpheniramine, dextromethorphan, and phenylephrine, or you may need a dosage adjustment or special tests during treatment.

Artificially-sweetened liquid forms of cough-and-cold medications may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take chlorpheniramine, dextromethorphan, and phenylephrine?

Use this medication exactly as directed on the label or as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Symptoms of an overdose may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking chlorpheniramine, dextromethorphan, and phenylephrine?

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by chlorpheniramine, dextromethorphan, and phenylephrine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor"s advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

What are the possible side effects of chlorpheniramine, dextromethorphan, and phenylephrine?

• fast, pounding, or uneven heartbeat;

• confusion, hallucinations, unusual thoughts or behavior;

• severe dizziness, anxiety, restless feeling, or nervousness;

• increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

• confusion, hallucinations;

• slow, shallow breathing;

• urinating less than usual or not at all;

• easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Keep taking the medication and talk to your doctor if you have any of these less serious side effects:

• blurred vision;

• dry mouth;

• nausea, stomach pain, constipation;

• mild loss of appetite, stomach upset;

• warmth, tingling, or redness under your skin;

• feeling excited or restless;

• sleep problems (insomnia);

• restless or excitability (especially in children);

• skin rash or itching;

• dizziness, drowsiness;

• problems with memory or concentration; or

• ringing in your ears.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect chlorpheniramine, dextromethorphan, and phenylephrine?

Before taking this medication, tell your doctor if you are using any of the following drugs:

• an antidepressant;

• a diuretic (water pill);

• medication to treat irritable bowel syndrome;

• celecoxib (Celebrex);

• cinacalcet (Sensipar);

• darifenacin (Enablex);

• imatinib (Gleevec);

• quinidine (Quinaglute, Quinidex);

• ranolazine (Ranexa)

• ritonavir (Norvir);

• sibutramine (Meridia);

• terbinafine (Lamisil);

• medicines to treat high blood pressure;

• aspirin or salicylates (such as Disalcid, Doan"s Pills, Dolobid, Salflex, Tricosal, and others);

• bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); or

• a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.

There may be other drugs that can affect chlorpheniramine, dextromethorphan, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about chlorpheniramine, dextromethorphan, and phenylephrine written for health professionals that you may read.

What does my medication look like?

Chlorpheniramine, dextromethorphan, and phenylephrine is available over-the-counter under the brand name Cerose DM. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.