 |
drug-information.ru |
|Econazole Econazole Cream |
| Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home EconazoleGeneric Name: Econazole nitrate Dosage Form: Cream Rx only For Topical Use Only Econazole DescriptionEconazole Nitrate Cream, 1% contains the antifugal agent, Econazole nitrate 1%, in a water-miscible base consisting of pegoxol 7 stearate, peglicol 5 oleate, mineral oil, benzoic acid, butylated hydroxyanisole, and purified water. The white to off-white soft cream is for topical use only. Chemically, Econazole nitrate is 1-[2-{(4-chloro-phenyl) methoxy}-2-(2,4dichlorophenyl) ethyl]-1 H-imidazole mononitrate. Its structure is as follows:  Econazole - Clinical PharmacologyAfter topical application to the skin of normal subjects, systemic absorption of Econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes. Inhibitory concentrations were achieved in the epidermis and as deep as the middle region of the dermis. Less than 1% of the applied dose was recovered in the urine and feces. MicrobiologyEconazole nitrate has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section.
Econazole nitrate exhibits broad-spectrum antifungal activity against the following organisms in vitro, but the clinical significance of these data is unknown.
Indications and Usage for EconazoleEconazole Nitrate Cream, 1% is indicated for topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor. ContraindicationsEconazole Nitrate Cream, 1% is contraindicated in individuals who have shown hypersensitivity to any of its ingredients. WarningsEconazole Nitrate Cream, 1% is not for ophthalmic use. PrecautionsGeneralIf a reaction suggesting sensitivity or chemical irritation should occur, use of the medication should be discontinued. For external use only. Avoid introduction of Econazole Nitrate Cream, 1% into the eyes. Carcinogenicity StudiesLong-term animal studies to determine carcinogenic potential have not been performed. Fertility (Reproduction)Oral administration of Econazole nitrate in rats has been reported to produce prolonged gestation. Intravaginal administration in humans has not shown prolonged gestation or other adverse reproductive effects attributable to Econazole nitrate therapy. PregnancyPregnancy Category C. Econazole nitrate has not been shown to be teratogenic when administered orally to mice, rabbits or rats. Fetotoxic or embryotoxic effects were observed in Segment I oral studies with rats receiving 10 to 40 times the human dermal dose. Similar effects were observed in Segment II or Segment III studies with mice, rabbits and/or rats receiving oral doses 80 or 40 times the human dermal dose. Econazole nitrate should be used in the first trimester of pregnancy only when the physician considers it essential to the welfare of the patient. The drug should be used during the second and third trimesters of pregnancy only if clearly needed. Nursing MothersIt is not known whether Econazole nitrate is excreted in human milk. Following oral administration of Econazole nitrate to lactating rats, Econazole and/or metabolites were excreted in milk and were found in nursing pups. Also, in lactating rats receiving large oral doses (40 or 80 times the human dermal dose), there was a reduction in post partum viability of pups and survival to weaning; however, at these high doses, maternal toxicity was present and may have been a contributing factor. Caution should be exercised when Econazole nitrate is administered to a nursing woman. Adverse ReactionsDuring clinical trials, approximately 3% of patients treated with Econazole nitrate 1% cream reported side effects thought possibly to be due to the drug, consisting mainly of burning, itching, stinging, and erythema. One case of pruritic rash has also been reported. OVERDOSEOverdosage of Econazole nitrate in humans has not been reported to date. In mice, rats, guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and >160 mg/kg, respectively. Econazole Dosage and AdministrationSufficient Econazole Nitrate Cream, 1% should be applied to cover affected areas once daily in patients with tinea pedis, tinea cruris, tinea corporis, and tinea versicolor, and twice daily (morning and evening) in patients with cutaneous candidiasis. Early relief of symptoms is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun; however, candidal infections and tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence. If a patient shows no clinical improvement after the treatment period, the diagnosis should be redetermined. Patients with tinea versicolor usually exhibit clinical and mycological clearing after two weeks of treatment. How is Econazole SuppliedEconazole Nitrate Cream, 1% is supplied in tubes of 15 grams, 30 grams, and 85 grams. Store Econazole Nitrate Cream, 1% at 20 – 25°C (68 – 77°F) [see USP Controlled Room Temperature]. Mfg. By: CLAY-PARK LABS, INC. Bronx, NY 10457 October, 2006
Revised: 01/2007 Where can I get more information about Econazole Econazole Cream ? We recommend to use www.Drugs.com Typical mistypes for Econazole Econazole Cream wconazole econazole cream, sconazole econazole cream, dconazole econazole cream, rconazole econazole cream, 4conazole econazole cream, 3conazole econazole cream, exonazole econazole cream, evonazole econazole cream, efonazole econazole cream, edonazole econazole cream, ecinazole econazole cream, ecknazole econazole cream, eclnazole econazole cream, ecpnazole econazole cream, ec0nazole econazole cream, ec9nazole econazole cream, ecobazole econazole cream, ecomazole econazole cream, ecojazole econazole cream, ecohazole econazole cream, econzzole econazole cream, econszole econazole cream, econwzole econazole cream, econqzole econazole cream, econaxole econazole cream, econasole econazole cream, econaaole econazole cream, econazile econazole cream, econazkle econazole cream, econazlle econazole cream, econazple econazole cream, econaz0le econazole cream, econaz9le econazole cream, econazoke econazole cream, econazope econazole cream, econazooe econazole cream, econazolw econazole cream, econazols econazole cream, econazold econazole cream, econazolr econazole cream, econazol4 econazole cream, econazol3 econazole cream, econazole wconazole cream, econazole sconazole cream, econazole dconazole cream, econazole rconazole cream, econazole 4conazole cream, econazole 3conazole cream, econazole exonazole cream, econazole evonazole cream, econazole efonazole cream, econazole edonazole cream, econazole ecinazole cream, econazole ecknazole cream, econazole eclnazole cream, econazole ecpnazole cream, econazole ec0nazole cream, econazole ec9nazole cream, econazole ecobazole cream, econazole ecomazole cream, econazole ecojazole cream, econazole ecohazole cream, econazole econzzole cream, econazole econszole cream, econazole econwzole cream, econazole econqzole cream, econazole econaxole cream, econazole econasole cream, econazole econaaole cream, econazole econazile cream, econazole econazkle cream, econazole econazlle cream, econazole econazple cream, econazole econaz0le cream, econazole econaz9le cream, econazole econazoke cream, econazole econazope cream, econazole econazooe cream, econazole econazolw cream, econazole econazols cream, econazole econazold cream, econazole econazolr cream, econazole econazol4 cream, econazole econazol3 cream, econazole econazole xream, econazole econazole vream, econazole econazole fream, econazole econazole dream, econazole econazole ceeam, econazole econazole cdeam, econazole econazole cfeam, econazole econazole cteam, econazole econazole c5eam, econazole econazole c4eam, econazole econazole crwam, econazole econazole crsam, econazole econazole crdam, econazole econazole crram, econazole econazole cr4am, econazole econazole cr3am, econazole econazole crezm, econazole econazole cresm, econazole econazole crewm, econazole econazole creqm, econazole econazole crean, econazole econazole creak, econazole econazole creaj, conazole econazole cream, eonazole econazole cream, ecnazole econazole cream, ecoazole econazole cream, econzole econazole cream, econaole econazole cream, econazle econazole cream, econazoe econazole cream, econazol econazole cream, econazole econazole cream, econazole econazole cream, econazole conazole cream, econazole eonazole cream, econazole ecnazole cream, econazole ecoazole cream, econazole econzole cream, econazole econaole cream, econazole econazle cream, econazole econazoe cream, econazole econazol cream, econazole econazolecream, econazole econazole ream, econazole econazole ceam, econazole econazole cram, econazole econazole crem, econazole econazole crea, ceonazole econazole cream, eocnazole econazole cream, ecnoazole econazole cream, ecoanzole econazole cream, econzaole econazole cream, econaozle econazole cream, econazloe econazole cream, econazoel econazole cream, econazol e econazole cream, econazole econazole cream, econazole e conazole cream, econazole ceonazole cream, econazole eocnazole cream, econazole ecnoazole cream, econazole ecoanzole cream, econazole econzaole cream, econazole econaozle cream, econazole econazloe cream, econazole econazoel cream, econazole econazol ecream, econazole econazolec ream, econazole econazole rceam, econazole econazole ceram, econazole econazole craem, econazole econazole crema, eeconazole econazole cream, ecconazole econazole cream, ecoonazole econazole cream, econnazole econazole cream, econaazole econazole cream, econazzole econazole cream, econazoole econazole cream, econazolle econazole cream, econazolee econazole cream, econazole econazole cream, econazole econazole cream, econazole eeconazole cream, econazole ecconazole cream, econazole ecoonazole cream, econazole econnazole cream, econazole econaazole cream, econazole econazzole cream, econazole econazoole cream, econazole econazolle cream, econazole econazolee cream, econazole econazole cream, econazole econazole ccream, econazole econazole crream, econazole econazole creeam, econazole econazole creaam, econazole econazole creamm, etc.
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||