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|Duramorph Solution

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Duramorph Solution

Generic Name: Morphine Injection Solution (Preservative Free) (MORE-feen)
Brand Name: Examples include Astramorph PF and Duramorph

Duramorph Solution is used for:

Treating pain. It may also be used for other conditions as determined by your doctor.

Duramorph Solution is a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, breathing and circulatory systems) at higher doses.

Do NOT use Duramorph Solution if:

you are allergic to any ingredient in Duramorph Solution
you are taking cimetidine, a phenothiazine (eg, chlorpromazine), sodium oxybate (GHB), or a tricyclic antidepressant (eg, amitriptyline), or you drink alcohol
you have known or suspected paralysis of the intestines or antibiotic-associated colitis
you have diarrhea due to poisoning
you have an upper airway (breathing) obstruction or low blood volume, or you are having an asthma attack
you will be having general anesthesia

Contact your doctor or health care provider right away if any of these apply to you.

Before using Duramorph Solution:

Some medical conditions may interact with Duramorph Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems, or you have a history of drug abuse or dependence
if you have increased pressure in the head, a recent head injury, or lesions in the head
if you have heart, liver, or thyroid disease; curvature of the spine; seizures; or a history of suicidal thoughts or behaviors
if you have a stomach blockage or inflammatory bowel disease, or you recently had stomach tract surgery

Some MEDICINES MAY INTERACT with Duramorph Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

Fluoxetine, naltrexone, rifampin, or risperidone because they may decrease the effectiveness of Duramorph Solution
Barbiturate anesthetics (eg, thiopental), cimetidine, ethanol, ketorolac, phenothiazines (eg, chlorpromazine), sodium oxybate (GHB ), or tricyclic antidepressants (eg, amitriptyline) because side effects (eg, disorientation, respiratory depression, seizures) may occur
Barbiturate anesthetics (eg, thiopental) or sodium oxybate (GHB) because the risk of their side effects may be increased by Duramorph Solution
Mexiletine or trovafloxacin because their effectiveness may be decreased by Duramorph Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Duramorph Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Duramorph Solution:

Use Duramorph Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Duramorph Solution is usually given as an injection at your doctor"s office, hospital, or clinic. If you will be using Duramorph Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Duramorph Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Do not use Duramorph Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
If you also take trovafloxacin, do not take it within 4 hours before or after taking Duramorph Solution. Check with your doctor if you have questions.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
If you miss a dose of Duramorph Solution and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Duramorph Solution.

Important safety information:

Duramorph Solution may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Duramorph Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Duramorph Solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
The risk of Duramorph Solution becoming habit-forming may be greater if you take it in high doses or for a long time. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
Tell your doctor or dentist that you take Duramorph Solution before you receive any medical or dental care, emergency care, or surgery.
Do not take Duramorph Solution if you have had a severe allergic reaction to morphine or hydromorphone (eg, MS Contin, Roxanol, Dilaudid). If you have a question about whether you are allergic to Duramorph Solution or if a certain medicine contains morphine or hydromorphone, contact your doctor or pharmacist.
Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.
Lab tests, including liver function, kidney function, lung function, and complete blood cell counts, may be performed while you use Duramorph Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Duramorph Solution with caution in the ELDERLY; they may be more sensitive to its effects.
Duramorph Solution should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Duramorph Solution while you are pregnant. Duramorph Solution is found in breast milk. Do not breast-feed while taking Duramorph Solution.

When used for long periods of time or at high doses, Duramorph Solution may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if this medicine stops working well. Do not take more than prescribed.

Some people who use Duramorph Solution for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking Duramorph Solution suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Duramorph Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; anxiety; changes in vision; confusion; constipation; decreased sex drive; dizziness; drowsiness; dry mouth; exaggerated sense of well-being; fear; frequent urination; headache; incoordination; lack of energy; lightheadedness; loss of appetite; mental clouding; mood swings; nausea; pinpoint pupils; restless mood; sleeplessness; sweating; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased sexual ability; delirium; difficulty urinating; disorientation; fainting; fast or slow heartbeat; flushing of the face; hallucinations; itching; menstrual changes; mental or mood changes; pounding in the chest; seizures; slowed breathing; tremor; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include cold and clammy skin; convulsions; deep sleep; dizziness; drowsiness; lightheadedness; loss of consciousness; slowed breathing; slowed heartbeat.

Proper storage of Duramorph Solution:

Store Duramorph Solution between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep out of reach of children and away from pets.

General information:

If you have any questions about Duramorph Solution, please talk with your doctor, pharmacist, or other health care provider.
Duramorph Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Duramorph Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006

Database Edition 06.4.1.002

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