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Dolobid, |diflunisal

diflunisal

Generic Name: diflunisal (die flu NI sal)
Brand Names: Dolobid

What is diflunisal?

Diflunisal is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diflunisal works by reducing hormones that cause inflammation and pain in the body.

Diflunisal is used to reduce pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and injury.

Diflunisal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about diflunisal?

Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous.

Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to diflunisal (such as ibuprofen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.

What should I discuss with my healthcare provider before taking diflunisal?

Before taking diflunisal, tell your doctor if you

• have an allergy to aspirin or any other NSAIDs,

• have an ulcer or bleeding in the stomach,

• have liver or kidney disease,

• have a coagulation (bleeding) disorder,

• have congestive heart failure,

• have fluid retention,

• have heart disease, or

• have high blood pressure.

You may not be able to take diflunisal, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take diflunisal?

Take diflunisal exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

What happens if I miss a dose?

If you are taking diflunisal on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose.

If you are taking diflunisal as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.

What happens if I overdose?

Symptoms of an diflunisal overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing.

What should I avoid while taking diflunisal?

Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to diflunisal (such as ibuprofen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.

Diflunisal side effects

Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous.

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• muscle cramps, numbness, or tingling;

• ulcers (open sores) in the mouth;

• rapid weight gain (fluid retention);

• seizures;

• decreased hearing or ringing in the ears;

• yellowing of the skin and eyes (jaundice); or

• abdominal cramping, indigestion, or heartburn.

Other, less serious side effects may be more likely to occur. Continue to take diflunisal and talk to your doctor if you experience

• dizziness or headache;

• nausea, diarrhea, or constipation;

• depression;

• fatigue or weakness;

• dry mouth; or

• irregular menstrual periods.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect diflunisal?

Before taking diflunisal, tell your doctor if you are taking any of the following drugs:

• aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan"s, others);

• another nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Motrin, Advil, others), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT), ketorolac (Toradol), meloxicam (Mobic), etodolac (Lodine), nabumetone (Relafen), naproxen (Aleve, Naprosyn, Anaprox, others), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);

• an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, naproxen, or ketoprofen;

• an anticoagulant (blood thinner) such as warfarin (Coumadin);

• methotrexate (Rheumatrex, Trexall);

• cyclosporine (Neoral, Sandimmune);

• hydrochlorothiazide (Microzide, Hydrocot, others); or

• bismuth subsalicylate in drugs such as Pepto-Bismol.

You may not be able to take diflunisal, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with diflunisal. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about diflunisal written for health professionals that you may read.

What does my medication look like?

Diflunisal is available with a prescription under the brand name Dolobid. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.