drug-information.ru |
|Dexrazoxane |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home DexrazoxanePronouncation: (dex-ray-ZOX-ane)Class: Cardioprotective agent Trade Names: Mechanism of ActionPharmacologyDexrazoxane is a potent intracellular chelating agent. The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. PharmacokineticsAbsorptionC max is 36.5 mcg/mL (at end of infusion). DistributionVd approximately 22 L/m 2 . Not bound to plasma proteins. MetabolismMetabolized to a diacid-diamide cleavage product and 2 monoacid-monoamide ring products. EliminationElimination t ½ is 2.1 to 2.5 hr. Plasma Cl is 6.25 to 7.88 L/hr/m 2 . Renal Cl is 3.35 L/hr/m 2 ; 42% excreted in urine. Indications and UsageReduce incidence and severity of cardiomyopathy in female breast cancer patients who have received a cumulative doxorubicin dose of 300 mg/m 2 and who may benefit from additional doxorubicin therapy. It is not recommended for use with the initiation of doxorubicin therapy. Unlabeled UsesCardioprotectant for other anthracyclines. ContraindicationsDo not use with chemotherapy regimens that do not contain an anthracycline. Dosage and AdministrationCardiomyopathyAdults IV The recommended IV dosage ratio of dexrazoxane:doxorubicin is 10:1 (eg, 500 mg/m 2 dexrazoxane would be given with 50 mg/m 2 doxorubicin). Doxorubicin must be administered within 30 min of starting the dexrazoxane infusion. General Advice
Storage/StabilityStore powder for injection at controlled room temperature (59° to 86°F). Reconstituted and diluted solutions are stable for 6 hr at controlled room temperature or under refrigeration (36° to 46°F). Discard any unused solution. Drug InteractionsOther chemotherapeutic agentsMay increase the myelosuppressive effects of other chemotherapeutic agents. IncompatibilityDo not mix with other drugs. Laboratory Test InteractionsNone well documented. Adverse ReactionsDermatologicAlopecia; urticaria; streaking/erythema; recall skin reaction. CNSFatigue; malaise; neurotoxicity. GINausea; vomiting; dysphagia; stomatitis; diarrhea; elevated transaminases; anorexia; esophagitis. HematologicDose-related additive myelosuppression; leukopenia; thrombocytopenia; granulocytopenia. MiscellaneousPain on injection; sepsis; phlebitis; hemorrhage; infection; fever. Precautions
PregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established. Hepatic FunctionDose reduction is recommended. FertilityTesticular atrophy. Anthracycline-induced cardiac toxicityCarefully monitor cardiac function. Antitumor interferenceThe use of dexrazoxane concurrently with the initiation of fluorouracil, doxorubicin, cyclosporine (FAC) therapy may interfere with the antitumor efficacy of the regimen; this use is not recommended. CarcinogenesisSecondary malignancies (primarily acute myeloid leukemia) have been reported in patients treated chronically with razoxane. Extravasation riskLocal irritation or phlebitis may occur. Refer to institution-specific protocol. Patient Information
Where can I get more information about Dexrazoxane ? We recommend to use www.Drugs.com Typical mistypes for Dexrazoxane sexrazoxane, xexrazoxane, cexrazoxane, fexrazoxane, rexrazoxane, eexrazoxane, dwxrazoxane, dsxrazoxane, ddxrazoxane, drxrazoxane, d4xrazoxane, d3xrazoxane, dezrazoxane, decrazoxane, dedrazoxane, desrazoxane, dexeazoxane, dexdazoxane, dexfazoxane, dextazoxane, dex5azoxane, dex4azoxane, dexrzzoxane, dexrszoxane, dexrwzoxane, dexrqzoxane, dexraxoxane, dexrasoxane, dexraaoxane, dexrazixane, dexrazkxane, dexrazlxane, dexrazpxane, dexraz0xane, dexraz9xane, dexrazozane, dexrazocane, dexrazodane, dexrazosane, dexrazoxzne, dexrazoxsne, dexrazoxwne, dexrazoxqne, dexrazoxabe, dexrazoxame, dexrazoxaje, dexrazoxahe, dexrazoxanw, dexrazoxans, dexrazoxand, dexrazoxanr, dexrazoxan4, dexrazoxan3, exrazoxane, dxrazoxane, derazoxane, dexazoxane, dexrzoxane, dexraoxane, dexrazxane, dexrazoane, dexrazoxne, dexrazoxae, dexrazoxan, edxrazoxane, dxerazoxane, derxazoxane, dexarzoxane, dexrzaoxane, dexraozxane, dexrazxoane, dexrazoaxne, dexrazoxnae, dexrazoxaen, ddexrazoxane, deexrazoxane, dexxrazoxane, dexrrazoxane, dexraazoxane, dexrazzoxane, dexrazooxane, dexrazoxxane, dexrazoxaane, dexrazoxanne, dexrazoxanee, etc.
|