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|Daunorubicin Hydrochloride |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Daunorubicin HydrochloridePronouncation: (DAW-no-RUE-bih-sin)Class: Anthracycline Trade Names: Mechanism of ActionPharmacologyAntimitotic and cytotoxic activity. PharmacokineticsDistributionExtensive and rapid protein binding. Highest concentrations in spleen, kidneys, liver, lungs, and heart. MetabolismExtensively metabolized in liver and other tissues to daunorubicinol (active). Eliminationt ½ is 18.5 hr (daunorubicin) and 26.7 hr (daunorubicinol). Approximately 25% excreted in active form in the urine and 40% by biliary excretion. Indications and UsageAcute lymphocytic leukemia. Unlabeled UsesChronic myelogenous leukemia, Kaposi sarcoma. ContraindicationsNone well documented. Dosage and AdministrationAcute Nonlymphocytic Leukemia (Combination Therapy)Adults (under 60 yr) IV Daunorubicin 45 mg/m 2 /day on days 1 to 3 of first course and days 1 to 2 of subsequent courses. May require up to 3 courses. Adults (over 60 yr)IV Daunorubicin 30 mg/m 2 /day on days 1 to 3 of first course and days 1 to 2 of subsequent courses. May require 3 courses. Acute Lymphocytic Leukemia (Combination Therapy)Adults IV Daunorubicin 45 mg/m 2 /day on days 1 to 3. Acute Lymphocytic LeukemiaChildren (at least 2 yr) IV Daunorubicin 25 mg/m 2 on day 1 q wk with vincristine and oral prednisone. Generally, complete remission will be obtained with 4 courses of therapy. If after 4 courses the patient is in partial remission, an additional 1 or, if necessary, 2 courses may be given. Children (under 2 yr or under 0.5 m 2 BSA)IV Calculate dosage on the basis of weight (mg/kg) instead of BSA. Dosage Adjustment for Renal or Hepatic FunctionIf serum bilirubin is 1.2 to 3 mg/dL, then give 75% of adjusted dose from prior course. If serum bilirubin is above 3 mg/dL or serum creatinine is above 3 mg/dL, then give 50% of adjusted dose from prior course. Lifetime Cumulative Doses Above Which Frequency of Cardiotoxicity IncreasesAdults IV No more than 550 mg/m 2 . Adults having received mediastinal radiationIV No more than 400 mg/m 2 . Children (at least 2 yr)IV No more than 300 mg/m 2 . Children (under 2 yr)IV No more than 10 mg/m 2 . General Advice
Storage/StabilityStore powder at room temperature (59° to 86°F). Protect from light. Refrigerate unopened vials of solution. Protect from light. Drug InteractionsCyclophosphamideMay result in increased daunorubicin toxicity. Hepatotoxic medicationsMay impair liver function and increase the risk of toxicity. Myelosuppressive agentsDosage reduction of daunorubicin may be required. Quinolone antibioticsDaunorubicin may decrease the oral absorption of quinolone antibiotics. Laboratory Test InteractionsHyperuricemiaMay be induced secondary to a rapid lysis of leukemic cells. As a precaution, administer allopurinol prior to initiating antileukemic therapy. Adverse ReactionsCardiovascularDelayed dose-related cardiomyopathy; acute arrhythmias. DermatologicAlopecia; rash; contact dermatitis; urticaria; radiation recall; nail hyperpigmentation. GINausea; vomiting; mucositis; esophagitis; diarrhea; abdominal pain. HematologicBone marrow suppression. HypersensitivityAnaphylaxis. MiscellaneousFever; chills. Precautions
PregnancyCategory D . LactationAdvise mothers to discontinue nursing. ChildrenCardiotoxicity may be more frequent and occur at lower cumulative doses. ElderlyCardiotoxicity may be more frequent. Use caution in patients who have inadequate bone marrow reserves because of old age. Renal FunctionSome health care providers recommend not giving daunorubicin to patients with a bilirubin above 5 mg/dL. Reduce dose. Hepatic FunctionSome health care providers recommend not giving daunorubicin to patients with a bilirubin above 5 mg/dL. Reduce dose. ECGMonitor ECG and systolic ejection fraction as the maximum cumulative lifetime dose approaches. Certain ECG changes and a decrease in the systolic injection fraction from pretreatment baseline may aid in recognizing those patients at greatest risk. A decrease of at least 30% in limb lead QRS voltage has been associated with significant risk of drug-induced cardiomyopathy. Perform an ECG or determine systolic ejection fraction before each course. Extravasation riskLocal irritation of phlebitis may occur. Refer to the institution"s specific protocol. Health care provider administrationIt is recommended that daunorubicin be administered only by health care providers who are experienced in leukemia chemotherapy. MyelosuppressionOccurs when used in therapeutic doses; this may lead to infection or hemorrhage. Myocardial toxicityPotentially fatal CHF may occur when total cumulative dosage exceeds 400 to 550 mg/m 2 in adults, 300 mg/m 2 in children above 2 yr, or 10 mg/kg in children under 2 yr. This may occur during therapy or several months to years after therapy. Previous cumulative doseDo not use in patients who have previously received the recommended maximum cumulative dose of either doxorubicin or daunorubicin. Secondary leukemiasThere have been reports of secondary leukemias in patients exposed to daunorubicin when used in combination with other antineoplastic agents or radiation therapy. Patient Information
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