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Generic Name: Dantrolene Injection (DAN-troe-leen)
Brand Name: Dantrium

Dantrium is used for:

Treating episodes of severe high body temperature (malignant hyperthermia). It is also used to prevent or reduce the risk of severe high body temperature in certain patients before or after surgery or anesthesia. It may also be used for other conditions as determined by your doctor.

Dantrium is a muscle relaxant. It works by restoring a healthy level of calcium in the muscles, which helps to prevent or reduce severe high body temperature.

Do NOT use Dantrium if:

  • you are allergic to any ingredient in Dantrium

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dantrium :

Some medical conditions may interact with Dantrium . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems, lung problems, (eg, obstructive pulmonary disease), or liver problems
  • if you are older than 35 years of age

Some MEDICINES MAY INTERACT with Dantrium . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Verapamil because the risk of side effects, such as heart problems, may be increased
  • Estrogen because the risk of liver problems may be increased
  • Neuromuscular blockers (eg, vecuronium) because the actions and side effects may be increased by Dantrium

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dantrium may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dantrium :

Use Dantrium as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Dantrium is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Dantrium at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Dantrium contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Dantrium , contact your doctor or health care provider immediately.

Ask your health care provider any questions you may have about how to use Dantrium .

Important safety information:

  • Dantrium may cause dizziness, drowsiness, or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dantrium . Using Dantrium alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Dantrium . Dantrium will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • To reduce the risk of choking, be sure to chew food thoroughly and swallow small amounts of food on days when Dantrium is administered.
  • LAB TESTS, including pulse and blood pressure, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Dantrium during pregnancy. Dantrium is excreted in breast milk. Do not breast-feed while taking Dantrium .

Possible side effects of Dantrium :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Decreased grip strength; diarrhea; dizziness; drowsiness; general body discomfort; lightheadedness; muscle weakness; nausea; pain or redness at injection site; unusual tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood vessel inflammation; chest pain; dark urine; difficulty swallowing; inflammation at the injection site; severe stomach or abdominal pain; shallow breathing; unusual tiredness; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include loss of consciousness; severe diarrhea; severe muscle weakness; vomiting.

Proper storage of Dantrium :

Dantrium is usually handled and stored by a health care provider. If you are using Dantrium at home, store Dantrium as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Use within 6 hours. Keep Dantrium out of the reach of children and away from pets.

General information:

  • If you have any questions about Dantrium , please talk with your doctor, pharmacist, or other health care provider.
  • Dantrium is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Dantrium . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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