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Generic Name: Danazol (DAN-uh-zole)
Brand Name: Generic only. No brands available.

Do not use Danazol if you are pregnant. It is recommended that a pregnancy test be performed before starting Danazol . Effective, nonhormonal contraceptive (birth control) measures, such as diaphragms and condoms, should be used while taking Danazol . Danazol may cause serious harm to a fetus. If you become pregnant while taking Danazol , stop use and contact your health care provider. Life-threatening strokes and increased pressure in the head have occurred from using Danazol . Notify your doctor immediately if you develop any of the following: one-sided weakness, sudden vision changes, slurred speech, arm or leg pain, breathing trouble, chest pain, yellowing eyes/skin, dark urine, dizziness, fainting, swelling, stomach pain, head pain.

Danazol is used for:

Treating endometriosis, symptoms of fibrocystic breast disease, orgiant hives. It may also be used for other conditions as determined by your doctor.

Danazol is a synthetic steroid. It works by decreasing the level of certain hormones, which reduces the symptoms and severity of the diseases treated by Danazol .

Do NOT use Danazol if:

  • you are allergic to any ingredient in Danazol
  • you are pregnant or breast-feeding
  • you have undiagnosed vaginal bleeding
  • you have the blood disease porphyria or severely decreased liver, kidney, or heart function

Contact your doctor or health care provider right away if any of these apply to you.

Before using Danazol :

Some medical conditions may interact with Danazol . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of blood clots or stroke, cancer, heart failure, heart disease, or liver or kidney problems

Some MEDICINES MAY INTERACT with Danazol . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), carbamazepine, cyclosporine, or macrolide immunosuppressants (eg, tacrolimus) because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Danazol :

Use Danazol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Danazol may be taken with or without food.
  • If you are being treated for endometriosis or fibrocystic breast disease, you should begin treatment during menstruation.
  • Endometriosis patients - You must take Danazol consistently for 3 to 6 months. It may be necessary to take Danazol for 9 months.
  • If you miss a dose of Danazol , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Danazol .

Important safety information:

  • Danazol may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Danazol . Using Danazol alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not take more medicine than prescribed unless advised to do so by your doctor.
  • It may take several months for Danazol to work. Do not stop using Danazol without checking with your doctor.
  • Use a barrier contraceptive (birth control), such as a condom or diaphragm, while taking Danazol .
  • Diabetes patients - Danazol may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
  • LAB TESTS, including liver function tests and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Danazol with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Danazol if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Danazol is excreted in breast milk. Do not breast-feed while taking Danazol .

Possible side effects of Danazol :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; changes in menstrual flow; changes in semen volume and sperm count; emotional problems; excessively oily skin; flushing; hair loss; nervousness; reduction in breast size; sweating; vaginal itching or dryness; voice changes (hoarseness, sore throat, change in pitch); weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal hair growth; arm or leg pain; breathing trouble; chest pain; dark urine; dizziness; fainting; headache; nausea; one-sided weakness; slurred speech; sore throat or fever; stomach pain; swelling; unusual bleeding or bruising; vision problems; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Danazol :

Store Danazol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Danazol out of the reach of children and away from pets.

General information:

  • If you have any questions about Danazol , please talk with your doctor, pharmacist, or other health care provider.
  • Danazol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Danazol . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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