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Generic name product may be available in the U.S. and Canada.
Sulfapyridine (sul-fa-PEER-i-deen) is a sulfa medicine. It is used to help control dermatitis herpetiformis (Duhring"s disease), a skin problem. It may also be used for other problems as determined by your doctor. However, this medicine will not work for any kind of infection as other sulfa medicines do.
This medicine may cause some serious side effects. Before using this medicine, be sure to talk to your doctor about these problems, as well as the good this medicine will do .
Sulfapyridine is available only with your doctor"s prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sulfapyridine, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to sulfa medicines, furosemide (e.g., Lasix) or thiazide diuretics (water pills), oral antidiabetics (diabetes medicine you take by mouth), glaucoma medicine you take by mouth (acetazolamide [e.g., Diamox], dichlorphenamide [e.g., Daranide], methazolamide [e.g., Neptazane]), or pyrimethamine (e.g., Daraprim). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Studies have not been done in humans. Studies in rats and mice have shown that some sulfa medicines, given by mouth in high doses, cause birth defects, including cleft palate and bone problems. In addition, sulfa medicines may cause liver problems in newborn infants. Therefore, use is not recommended during pregnancy.
Breast-feeding—Sulfapyridine passes into the breast milk. This medicine may cause liver problems in nursing babies. In addition, it may cause blood problems in nursing babies with glucose-6-phosphate dehydrogenase (G6PD) deficiency (lack of G6PD enzyme). Therefore, use is not recommended in nursing women.
Children—Use of this medicine is not recommended since dermatitis herpetiformis usually does not occur in children.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of sulfapyridine in the elderly with use in other age groups.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking sulfapyridine, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of sulfapyridine. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Each dose of sulfapyridine should be taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day , unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (e.g., kidney stones) of the sulfa medicine.
For patients taking sulfapyridine for dermatitis herpetiformis :
Dosing—The dose of sulfapyridine will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of sulfapyridine. Your dose may be different if you have kidney disease. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—For patients taking sulfapyridine for dermatitis herpetiformis : You may skip a missed dose if this does not make your symptoms return or get worse. If your symptoms do return or get worse, take the missed dose as soon as possible. Then go back to your regular dosing schedule.
Storage—To store this medicine:
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits . This medicine may cause blood problems, especially if it is taken for a long time.
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
Sulfapyridine may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.
Sulfapyridine may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:
You may still be more sensitive to sunlight or sunlamps for many months after stopping this medicine. If you have a severe reaction from the sun, check with your doctor .
Tell the doctor in charge that you are taking this medicine before you have any medical tests. The results of the bentiromide (e.g., Chymex) test for pancreas function are affected by this medicine.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Fever; headache (continuing); itching; skin rash
Aching of joints and muscles; difficulty in swallowing; pale skin; redness, blistering, peeling, or loosening of skin; sore throat; unusual bleeding or bruising; unusual tiredness or weakness; yellow eyes or skin
Blood in urine; lower back pain; pain or burning while urinating; swelling of front part of neck
Also, check with your doctor as soon as possible if the following side effect occurs:
Increased sensitivity of skin to sunlight
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Diarrhea; loss of appetite; nausea or vomiting
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, sulfapyridine is used in certain patients with the following medical conditions:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for these uses.
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