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|Conjugated Estrogens and Medroxyprogesterone |
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DescriptionConjugated estrogens and medroxyprogesterone (CON-ju-gate-ed ES-troe-jenz and me-DROX-ee-proe-JES-te-rone) are estrogen and progestin hormones. Along with other effects, estrogens help females develop sexually at puberty and regulate the menstrual cycle. Progestin lowers the effect of estrogen on the uterus and keeps estrogen-related problems from developing. Around the time of menopause, the ovaries produce less estrogen. Estrogens are given to:
There is no medical evidence to support the belief that the use of estrogens will keep the patient feeling young, keep the skin soft, or delay the appearance of wrinkles. Nor has it been proven that the use of estrogens during menopause will relieve emotional and nervous symptoms, unless these symptoms are related to the menopausal symptoms, such as hot flashes. Progestins are not needed if the uterus has been removed (by a surgical method called hysterectomy). In that case, it may be better to receive estrogens alone without the progestin. Conjugated estrogens and medroxyprogesterone are available only with your doctor"s prescription, in the following dosage forms:
Before Using This MedicineIn deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For conjugated estrogens and medroxyprogesterone, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to estrogens or progestins. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy—Conjugated estrogens and medroxyprogesterone are not recommended for use during pregnancy. Becoming pregnant or maintaining a pregnancy is not likely to occur around the time of menopause. Tell your doctor right away if you suspect you are pregnant. Breast-feeding—Conjugated estrogens and medroxyprogesterone pass into the breast milk. This medicine is not recommended for use during breast-feeding. Older adults—Conjugated estrogens and medroxyprogesterone may increase your chance of having a stroke, memory problems, or breast cancer that spreads to other parts of your body. Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking conjugated estrogens and medroxyprogesterone, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of conjugated estrogens and medroxyprogesterone. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This MedicineConjugated estrogens and medroxyprogesterone usually come with patient directions. Read them carefully before taking this medicine. Take this medicine only as directed by your doctor. Do not take more of it and do not take it for a longer period of time than your doctor ordered . The length of time you take the medicine will depend on the medical problem for which you are taking conjugated estrogens and medroxyprogesterone. Discuss with your doctor how long you will need to take these medicines. If you are taking the estrogen or progestin hormones in a certain order (i.e., conjugated estrogens tablets followed by conjugated estrogens and medroxyprogesterone tablets), be sure you know in which order you need to take the medicines . If you have questions about this, ask your health care professional. Nausea may occur during the first few weeks after you start taking estrogens. This effect usually disappears with continued use. If the nausea is bothersome, it can usually be prevented or reduced by taking each dose with food or immediately after food. Dosing—The dose of these medicines will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage—To store this medicine:
Precautions While Using This MedicineIt is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects . Plan on going to see your doctor every year, but some doctors require visits more often. Although the risk for developing breast problems or breast cancer is low, it is still important that you regularly check your breasts for any unusual lumps or discharge, and report any problems to your doctor. You should also have a mammogram (x-ray pictures of the breasts) and breast examination done by your doctor whenever your doctor recommends it. If your menstrual periods have stopped, they may start again once you begin taking this medicine. This effect will continue for as long as the medicine is taken. However, if taking the continuous treatment (0.625 mg conjugated estrogens and 2.5 mg medroxyprogesterone once a day), monthly bleeding usually stops within 10 months. Also, vaginal bleeding between your regular menstrual periods may occur during the first 3 months of use. Do not stop taking your medicine. Check with your doctor if bleeding continues for an unusually long time, if your period has not started within 45 days of your last period, or if you think you are pregnant. Tell the doctor in charge that you are taking this medicine before having any laboratory test, because some test results may be affected. You may need to stop taking this medicine before having some kinds of surgery or while your doctor has ordered a long period of bedrest. Talk with your doctor about this. Side Effects of This MedicineHealthy women rarely have severe side effects from taking conjugated estrogens or medroxyprogesterone to replace estrogen. Check with your doctor as soon as possible if any of the following side effects occur: More common Itching of the vagina or genital area; menstrual periods beginning again, including changing menstrual bleeding pattern for up to 6 months (spotting, breakthrough bleeding, prolonged or heavier vaginal bleeding, or vaginal bleeding completely stopping by 10 months); pain during sexual intercourse; thick, white vaginal discharge Less common Blurred vision; breast lumps; chest pain; discharge from breast; dizziness; feeling faint, dizzy, or light-headed; feeling of warmth or heat; flushing or redness of skin, especially on face and neck; headache; heavy nonmenstrual vaginal bleeding; nervousness; pounding in the ears; severe cramping of the uterus; skin rash; slow or fast heartbeat; sweating Rare Change in vaginal discharge; pain or feeling of pressure in pelvis; pain or tenderness in stomach, side, or abdomen; yellow eyes or skin Unknown acid or sour stomach; belching; backache; full or bloated feeling or pressure in the stomach; heartburn; indigestion; loss of appetite; stomach discomfort, upset or pain; swelling of abdominal or stomach area; abdominal bloating; pelvic pain; stomach pain Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome: More common Abdominal cramps; back pain; body aches or pain; breast pain or tenderness; congestion; chills; cough; crying; diarrhea; depersonalization; dryness or soreness of throat; dysphoria; enlarged breasts; euphoria; feeling faint, dizzy, or light-headedness; feeling of warmth or heat; fever; flushing or redness of skin, especially on face and neck; general feeling of discomfort or illness; headache, severe and throbbing; hoarseness; increase in amount of clear vaginal discharge; itching; joint pain; lack or loss of strength; mental depression; muscle aches and pains; nausea; pain; pain or tenderness around eyes and cheekbones; painful menstrual periods; painful or difficult urination; paranoia; passing of gas; quick to react or overreact emotionally; rapidly changing moods; runny nose; shivering; shortness of breath or troubled breathing; sneezing; sore throat; stuffy nose; stomach discomfort following meals; tender, swollen glands in neck; tightness of chest or wheezing; trouble sleeping; trouble in swallowing; unusual tiredness; voice changes; vomiting Less common Acne; bloating or swelling of face, ankles, or feet; cervix disorder; crying; depersonalization; dysphoria; euphoria; increase in sexual desire; leg cramps; mental depression; paranoia; quick to react or overreact emotionally; rapidly changing moods; sleeplessness; tense muscles; trouble sleeping; unable to sleep; unusual weight gain or loss Unknown light vaginal bleeding between periods and after intercourse; bloody vaginal discharge; bloody or cloudy urine; difficult, burning, or painful urination; frequent urge to urinate; abdominal cramping Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. Revised: 06/25/2004 The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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